Grundinformationen
- CAS
303-25-3- Standard-SMILES
CN1CCN(C(c2ccccc2)c2ccccc2)CC1.Cl- InChIKey
UKPBEPCQTDRZSE-UHFFFAOYSA-N- Summenformel
- C18H23ClN2
- Durchschnittliche Molmasse
- 302,8 g/mol
Überblick
Cyclizine hydrochloride is a hydrochloride salt consisting of equimolar amounts of cyclizine and hydrogen chloride. It has a role as a central nervous system depressant, a H1-receptor antagonist, a cholinergic antagonist and an antiemetic. It contains a cyclizine.
Namen und Bezeichner
- Bevorzugter Name
- Cyclizine Hydrochloride
- IUPAC
- 1-benzhydryl-4-methylpiperazine;hydrochloride
- Lokaler Name
- Cyclizinhydrochlorid
- Englischer Name
- Cyclizine Hydrochloride
- Summenformel
- C18H23ClN2
- Molmasse
- 302.84162
Namen und Synonyme
Cyclizine hydrochloride303-25-3CYCLIZINE HClMarezine hydrochloride1-(diphenylmethyl)-4-methylpiperazine hydrochlorideValoidColloxW0O1NHP4WE1-(Diphenylmethyl)-4-methylpiperazine monohydrochlorideNSC-169102(+-)-1-Diphenylmethyl-4-methylpiperazine hydrochloridePiperazine, 1-(diphenylmethyl)-4-methyl-, monohydrochloride
Weitere Namen anzeigen
Cyclizine HCl solutionEchnatolFortravelCYCLYZINE HCLEinecs 206-136-9cyclizinechloridemarezinehydrochlorideCyclizini hydrochloridum
CHEBI:51045NSC169102DTXCID2027753ValiodHCl, CyclizineHydrochloride, CyclizineRefChem:919340206-136-9
Datenbank-Bezeichner
- CAS
303-25-3
Eigenschaften
Berechnete Struktureigenschaften
- Polarare Oberfläche (TPSA)
- 6,5 Ų
- H-Brücken-Donoren
- 1
- H-Brücken-Akzeptoren
- 2
- Frei drehbare Bindungen
- 3
- Schwere Atome
- 21
- Formalladung
- 0
- Komplexität
- 253
Experimentelle und physikochemische Eigenschaften
Human DrugsBreast Feeding; Lactation; Antiemetics; Antihistamines; Anti-Allergic Agents; Gastrointestinal Agents
Physikochemische Eigenschaften
- Schmelzpunkt
- 258 · 258-260℃
- Siedepunkt
- 457.04 °C · 457.04°C (rough estimate)
- Dichte
- 1.0551 · 1.0551 (rough estimate)
- Brechungsindex
- 1.5749 · 1.5749 (estimate)
- storage temp.
- Refrigerator
- Löslichkeit
- 1 mg/ml · Methanol: 1 mg/ml
- Aggregatzustand
- solid
- Major Application
- pharmaceuticalpharmaceutical small molecule
- InChI
- 1S/C18H22N2.ClH/c1-19-12-14-20(15-13-19)18(16-8-4-2-5-9-16)17-10-6-3-7-11-17;/h2-11,18H,12-15H2,1H3;1H
- InChIKey
- UKPBEPCQTDRZSE-UHFFFAOYSA-N
- SMILES
- [Cl-].N3(CCN(CC3)C)C(c2ccccc2)c1ccccc1.[H+]
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
Danger
H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]
P203, P260, P262, P264, P270, P271, P280, P284, P301+P316, P302+P352, P304+P340, P316, P318, P320, P321, P330, P361+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 41 reports by companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Gefahrenhinweise
Regulatory InformationPiperazine, 1-(diphenylmethyl)-4-methyl-, monohydrochloride: Does not have an individual approval but may be used under an appropriate group standard
Other Safety InformationIMAP assessments - Piperazine, 1-(diphenylmethyl)-4-methyl-, monohydrochloride: Environment tier I assessment
Hazard Classes and CategoriesAcute Tox. 3 (100%)
Toxikologische Informationen
Effects During Pregnancy and Lactation◉ Summary of Use during Lactation
Sicherheitsdaten
- wgk
- 3
- ridadr
- 3249
- hs_code
- 2933595960
- risk_code
- 61-23/24/25-42/43
- Toxizität
- mouse,LD50,intraperitoneal,58mg/kg (58mg/kg),Pharmacology: International Journal of Experimental and Clinical Pharmacology. Vol. 13, Pg. 241, 1975.
Chemie und Industrie
Pharmakologische Informationen
MeSH Pharmacological Classification
Drugs used to prevent NAUSEA or VOMITING.
Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood.
Anwendungen
VerwendenCyclizine Hydrochloride is a piperazine derivative with anti-emetic activity that is useful in the prevention and treatment of nausea and vomiting associated with motion sickness. Antiemetic.
Vor- und nachgelagerte Produkte
Vorgelagerte Rohstoffe
Anbieter56 Anbieter
国药集团化学试剂有限公司86-21-63210123 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
LIDE PHARMACEUTICALS LIMITED+852-55945652 · [email protected]
上海策嵘生物科技有限公司[email protected]
Zugehörige Reaktionen
1
Notizen zur Verbindung
Wird geladen…