Metoprolol Fumarate
Grundinformationen
- CAS
80274-67-5- Standard-SMILES
COCCc1ccc(OCC(O)CNC(C)C)cc1.COCCc1ccc(OCC(O)CNC(C)C)cc1.O=C(O)/C=C/C(=O)O- InChIKey
BRIPGNJWPCKDQZ-WXXKFALUSA-N- Summenformel
- C34H54N2O10
- Durchschnittliche Molmasse
- 650,8 g/mol
- Monoisotopische Masse
- 650,37784592
Überblick
Metoprolol Fumarate is the fumarate salt form of metoprolol, a cardioselective competitive beta-1 adrenergic receptor antagonist with antihypertensive properties and devoid of intrinsic sympathomimetic activity. Metoprolol antagonizes beta 1-adrenergic receptors in the myocardium, thereby reducing the rate and force of myocardial contraction, and consequently a diminished cardiac output. This agent may also reduce the secretion of renin with subsequent reduction in levels of angiotensin II thereby preventing vasoconstriction and aldosterone secretion.
Namen und Bezeichner
- Bevorzugter Name
- Metoprolol Fumarate
- IUPAC
- (E)-but-2-enedioic acid;bis(1-[4-(2-methoxyethyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol)
- Englischer Name
- Metoprolol fumarate
- Summenformel
- C19H29NO7
- Molmasse
- 383.44
Namen und Synonyme
Metoprolol fumarate80274-67-5119637-66-0Lopresor OROSCGP 2175CLopressor OROUNII-IO1C09Z674LOPRESSOR OROSIO1C09Z674Metoprolol fumarate [USAN:USP]Metoprolol fumarate (USAN:USP)METOPROLOL FUMARATE (MART.)
Weitere Namen anzeigen
Metoprolol hemifumarateLopressor OROS|||CGP 2175C|||CGP 2175C1-(isopropylamino)-3-(4-(2-methoxyethyl)phenoxy)propan-2-ol hemifumarateMetoprolol Fumarate (2:1)Q: What is Metoprolol Fumarate (2:1) Q: What is the CAS Number of Metoprolol Fumarate (2:1) Q: What is the storage condition of Metoprolol Fumarate (2:1) Q: What are the applications of Metoprolol Fumarate (2:1)
METOPROLOL FUMARATE [MART.]METOPROLOL FUMARATE (USP-RS)METOPROLOL FUMARATE [USP-RS](+-)-1-(Isopropylamino)-3-(p-(2-methoxyethyl)phenoxy)-2-propanol fumarate (2:1) (salt)METOPROLOL FUMARATE (USP MONOGRAPH)METOPROLOL FUMARATE [USP MONOGRAPH]RefChem:55625Metoprolol (fumarate)
Datenbank-Bezeichner
- CAS
Eigenschaften
Berechnete Struktureigenschaften
- Polarare Oberfläche (TPSA)
- 176 Ų
- H-Brücken-Donoren
- 6
- H-Brücken-Akzeptoren
- 12
- Frei drehbare Bindungen
- 20
- Schwere Atome
- 46
- Formalladung
- 0
- Komplexität
- 334
Experimentelle und physikochemische Eigenschaften
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
Physikochemische Eigenschaften
- Schmelzpunkt
- 145 · 145 - 147°C
- storage temp.
- -20 °C · -20°C Freezer, Under inert atmosphere
- Löslichkeit
- Chloroform (Slightly), Methanol (Slightly)
- Aggregatzustand
- Solid
- Farbe
- White to Off-White
Chemie und Industrie
Anwendungen
VerwendenMetoprolol Fumarate is a β-adrenoceptor antagonist drug that is administered in an oral osmotic controlled-release system (OROS).
Anbieter12 Anbieter
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