3-(4-Pyridyl)indole
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Grundinformationen
- CAS
7272-84-6- Standard-SMILES
c1ccc2c(-c3ccncc3)c[nH]c2c1- InChIKey
LLJRXVHJOJRCSM-UHFFFAOYSA-N- Summenformel
- C13H10N2
- Durchschnittliche Molmasse
- 194,237 g/mol
- Monoisotopische Masse
- 194,08439832
Namen und Bezeichner
- Bevorzugter Name
- 3-(4-Pyridyl)indole
- IUPAC
- 3-(Pyridin-4-yl)-1H-indole
- Englischer Name
- 3-(4-Pyridyl)indole
- Summenformel
- C13H10N2
- Molmasse
- 194.23
Namen und Synonyme
3-(4-Pyridyl)3-(4-Pyridinyl)-ROCK Inhibitor III3-(4-Pyridyl)indoleRho Kinase Inhibitor III3-(4-Pyridinyl)-1H-indole1H-Indole, 3-(4-pyridinyl)-Rho Kinase Inhibitor III, RockoutRHO KINASE INHIBITOR IIIROCK INHIBITOR IIIROCKOUTRho Kinase Inhibitor III, Rockout - CAS 7272-84-6 - Calbiochem
Datenbank-Bezeichner
- CAS
7272-84-6- PubChem CID
- 644354
- DTXSID
DTXSID90349379- ChEMBL
CHEMBL380071- ChEBI
CHEBI:93984- Nikkaji
- J583.894K
Eigenschaften
Physikochemische Eigenschaften
- storage temp.
- 2 C · +2C to +8C
- Löslichkeit
- DMSO, Methanol
- Aggregatzustand
- Yellow solid
- Farbe
- Yellow
- Stabilität
- Light Sensitive
- InChI
- 1S/C13H10N2/c1-2-4-13-11(3-1)12(9-15-13)10-5-7-14-8-6-10/h1-9,15H
- InChIKey
- LLJRXVHJOJRCSM-UHFFFAOYSA-N
- SMILES
- [nH]1c2c(c(c1)c3ccncc3)cccc2
- CAS Datenbank
- 7272 · 7272-84-6
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
Sicherheitsdaten
- wgk
- WGK 1
- Speicherklasse
- 11 - Combustible Solids
Chemie und Industrie
Anwendungen
BeschreibungTwo Rho-associated kinases (ROCK), ROCK1 and ROCK2, act downstream of the G protein Rho to regulate cytoskeletal stability. The ROCKs play important roles in diverse cellular functions including cell adhesion and proliferation, smooth muscle contraction, and stem cell renewal. 3-(4-Pyridyl)indole is a ROCK1 inhibitor (IC50 = 25 μM) that promotes cell spreading, inhibits membrane blebbing, and induces dissolution of actin stress fibers in a wound healing assay. It also inhibits ROCK2 and PRK2, another Rho-dependent kinase, with similar potency, while inhibiting MSK-1 and PKA with relatively weaker potency.
VerwendenTwo Rho-associated kinases (ROCK), ROCK-I and ROCK-II, act downstream of the G protein Rho to regulate cytoskeletal stability. The ROCKs play important roles in diverse cellular functions including cell adhesion and proliferation, smooth muscle contraction, and stem cell renewal. 3-(4-Pyridyl)indole is a ROCK-I inhibitor (IC50 = 25 μM) that promotes cell spreading, inhibits membrane blebbing, and induces dissolution of actin stress fibers in a wound healing assay. It also inhibits ROCK-II and PRK2, another Rho-dependent kinase, with similar potency, while inhibiting MSK-1 and PKA with relatively weaker potency.[Cayman Chemical]
Anbieter14 Anbieter
Career Henan Chemica Co+86-0371-86658258 +86-13203830695 · [email protected]
Aladdin Scientific[email protected]
MedBio脉铂医药021-69568360 18916172912 · [email protected]
銳迪國際科技有限公司18024082417 · [email protected]
凯试（上海）科技有限公司021-50135380 · [email protected]
Sigma-Aldrich西格玛奥德里奇(上海)贸易有限公司021-61415566 800-8193336 · [email protected]
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