Grundinformationen
- Standard-SMILES
[Cl-].[Cl-].[Cl-].[Cr+3]- InChIKey
QSWDMMVNRMROPK-UHFFFAOYSA-K- Summenformel
- Cl3Cr
- Durchschnittliche Molmasse
- 158,35 g/mol
Überblick
Chromium(3+) trichloride is a chromium chloride with the chromium cation in the +3 oxidation state. It has a role as a sensitiser and a Lewis acid.
Namen und Bezeichner
- Bevorzugter Name
- Chromium(3+) trichloride
- IUPAC
- chromium(3+) trichloride
- Englischer Name
- chromium chloride
- Summenformel
- ClCr-
- Molmasse
- 158.36
Namen und Synonyme
chromium(3+) trichloride39345-92-1Cl3CrChromium(iii)chloridetris(chloranyl)chromiumChromium(III); chlorideSCHEMBL49822CHROMIC CHLORIDE [MI]CHEBI:53351CHROMIC CHLORIDE [WHO-DD]AKOS024437430DB09129
Weitere Namen anzeigen
CHROMIUM CHLORIDE
CHROMIC CHLORIDE ANHYDROUS [HSDB]Chromium(III) chloride pound CrCl3 pound(c)F099239F987909
Datenbank-Bezeichner
- CAS
10025-73-7、39345-92-1、50925-66-1- PubChem CID
- 6452300
- ChEBI
CHEBI:53351- UNII
- Z310X5O5RP
- Nikkaji
- J43.774C
Eigenschaften
Berechnete Struktureigenschaften
- Polarare Oberfläche (TPSA)
- 0 Ų
- H-Brücken-Donoren
- 0
- H-Brücken-Akzeptoren
- 3
- Frei drehbare Bindungen
- 0
- Schwere Atome
- 4
- Formalladung
- 0
- Komplexität
- 0
Chemie und Industrie
Pharmakologische Informationen
Protein BindingChromic chloride-induced binding of protein to red cells.
Pharmacodynamics
Trivalent chromium is part of glucose tolerance factor, an essential activator of insulin-mediated reactions. Chromium helps to maintain normal glucose metabolism and peripheral nerve function. Providing chromium during TPN helps prevent deficiency symptoms including impaired glucose tolerance, ataxia, peripheral neuropathy and a confusional state similar to mild/moderate hepatic encephalopathy.
Mechanism of Action
Metallic chromium has no biological activity. Chromium is referred as a glucose tolerance factor. This glucose tolerance factor is a complex of molecules. Glycine, cysteine, glutamic acid and nicotinic acid along with chromium form this complex.
Biological Half-Life31- 41 hours
Metabolism/Metabolites
The metabolism of chromic chloride hexahydrate in guinea pigs for 60 days after intratracheal injection of 200 ug Cr 10 min after injection, 69% of the dose remained in the lungs, & only 4% was found in the blood & liver, kidneys, spleen. By 24 hr, 45% was still in the lungs, 6% was excreted in the urine, & only a very small % was found in the other tissues. The spleen was the only tissue that showed accumulation & that occurred during the 1st 48 hr.
Absorption, Distribution and Excretion
Chromium absorption can increase with exercise.
Most absorbed chromium is excreted rapidly in the urine, whereas unabsorbed chromium is excreted through feces.
Chromium is stored in liver, spleen, soft tissue and bone.
Anbieter2 Anbieter
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