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Meclozindihydrochlorid
Meclozine Hcl · diadril · bonamine · NSC 28728 · Navidoxine · )-4-(3-methyL · Meclizine 2HCl · Meclizine diHCl
Identifikatoren & physikalische Daten
| CAS No. | 1104-22-9 |
|---|---|
| Summenformel | C25H29Cl3N2 |
| Durchschnittliche Molmasse | 463,88 g/mol |
| Monoisotopische Masse | 462,13963197 g/mol |
| SMILES | Cc1cccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)c1.Cl.Cl |
| InChIKey | VCTHNOIYJIXQLV-UHFFFAOYSA-N |
| PubChem CID | 64713 |
| ChEMBL | CHEMBL1324020 |
| EC No. | 214-164-8 |
| DTXSID | DTXSID9045348 |
| Lokaler Name | Meclozindihydrochlorid |
Chemische & physikalische Eigenschaften
| Schmelzpunkt | 210.0 to 214.0 °C |
|---|---|
| Lagerbedingungen | 2-8°C |
| Löslichkeit | DMSO: soluble5mg/mL, clear (warmed) |
| Aggregatzustand | powder |
| Farbe | white to beige |
| InChI | 1S/C25H27ClN2.2ClH/c1-20-6-5-7-21(18-20)19-27-14-16-28(17-15-27)25(22-8-3-2-4-9-22)23-10-12-24(26)13-11-23/h2-13,18,25H,14-17,19H2,1H32*1H |
| InChIKey | VCTHNOIYJIXQLV-UHFFFAOYSA-N |
| SMILES | [Cl-].[Cl-].Clc1ccc(cc1)C(N3CCN(CC3)Cc4cc(ccc4)C)c2ccccc2.[H+].[H+] |
| CAS Datenbank | 1104-22-9(CAS DataBase Reference) |
| EPA chemische Informationen | Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]-, dihydrochloride (1104-22-9) |
Sicherheit & Vorschriften
| Wassergefährdungsklasse (WGK) | 3 |
|---|---|
| TSCA-Inventar-Status | TSCA listed |
| Zollcode | 2933.59.8000 |
| RTECS-Nr. | TL2005000 |
| R-Sätze (R) | 22-63 |
| Toxizität | LD50 oral in mouse: 1600mg/kg |
| Gefahrensymbole | Xn |
| Sicherheitshinweise (S) | 22-36 |
| Lagerklasse | 11 - Combustible Solids |
| Gefahrenklasse | Acute Tox. 4 OralRepr. 2 |
Anwendungen & Verwendung
Beschreibung
Meclizine is a histamine H1 receptor antagonist (Ki = 250 nM). Pretreatment with meclizine (2.5-30 mg/kg, i.p.) reduces ovalbumin-induced mast cell degranulation, edema, and leukocyte influx in rat lung. Formulations containing meclizine have been used in the treatment of motion sickness and vertigo.
Verwenden
Meclizine Dihydrochloride is a histamine H1 receptor antagonist with antiemetic properties. Meclizine Dihydrochloride is a research product for neuroscience. This compound may exhibit neuroprotective properties.