HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Trimazosin Hydrochloride
Trimazosin HCl · Unii-827T79Ile7 · Trimazosin hydrochloride · Trimazosin hydrochlorid-1-wasser · Trimazosin hydrochloride monohydrate · Trimazosin monohydrochloride monohydrate · 4-(4-AMino-6,7,8-triMethoxy-2-quinazolinyl)-1-piperazinecarboxylic Acid 2-Hydroxy-2-Methylpropyl Ester Hydrochloride
Identifikatoren & physikalische Daten
| CAS No. | 53746-46-6 |
|---|---|
| Summenformel | C20H32ClN5O7 |
| Durchschnittliche Molmasse | 489,9 g/mol |
| Monoisotopische Masse | 489,1990261 g/mol |
| SMILES | COc1cc2c(N)nc(N3CCN(C(=O)OCC(C)(C)O)CC3)nc2c(OC)c1OC.Cl.O |
| InChIKey | WXMXALSEIGHTOR-UHFFFAOYSA-N |
| PubChem CID | 64749 |
| ChEMBL | CHEMBL3989848 |
| DTXSID | DTXSID40202021 |
Chemische & physikalische Eigenschaften
| Polarare Oberfläche (TPSA) | 134 |
|---|---|
| H-Brücken-Donoren | 4 |
| H-Brücken-Akzeptoren | 11 |
| Frei drehbare Bindungen | 7 |
| Schwere Atome | 33 |
| Formalladung | 0 |
| Komplexität | 603 |
| Schmelzpunkt | 166-169° (dec) |
| Lagerbedingungen | Refrigerator |
| Löslichkeit | DMSO (Slightly), Methanol (Slightly), Water (Slightly) |
| Aggregatzustand | Solid |
| Farbe | Off-White to Light Beige |
Anwendungen & Verwendung
Beschreibung
Trimazosin hydrochloride is a selective αl-adrenergic antagonist related to prazosin, bunazosin, and terazosin. It is reported to be longer acting than prazosin, without first dose hypotensive effects.
Verwenden
Trimazosin is useful in therapy as potent antihypertensive agents.