Grundinformationen
- CAS
77-46-3- Standard-SMILES
CC(=O)Nc1ccc(S(=O)(=O)c2ccc(NC(C)=O)cc2)cc1- InChIKey
AMTPYFGPPVFBBI-UHFFFAOYSA-N- Summenformel
- C16H16N2O4S
- Durchschnittliche Molmasse
- 332,4 g/mol
- Monoisotopische Masse
- 332,08307817
Überblick
Acedapsone is a sulfone that is dapsone in which both of the amino groups been acetylation. An antimicrobial drug, it also has antimalarial activity. It has a role as an antimicrobial drug and an antimalarial. It is an anilide, a secondary carboxamide, a member of acetamides and a sulfone. It is functionally related to a dapsone.
Namen und Bezeichner
- Bevorzugter Name
- Acedapsone
- IUPAC
- N-[4-(4-acetamidophenyl)sulfonylphenyl]acetamide
- Lokaler Name
- Acedapson
- Englischer Name
- acedapsone
- Summenformel
- C16H16N2O4S
- Molmasse
- 332.378
Namen und Synonyme
Acedapsone77-46-3DiacetyldapsoneSulfadiamineHansolarDADDSAcedapsonaAcedapsonumPAM-MR-1165CN-1883Bis(4-acetamidophenyl)sulfone4',4'''-Sulfonylbis(acetanilide)
Weitere Namen anzeigen
1399 fCamilanN,N'-Diacetyldapsone44SULPHONYLBISACETANILIDE-SULFONYLBIS(ACETANILIDE)4',4'''-sulfonylbis-acetanilid4,4'-diacetamidodiphenyl sulfone
4,4'-Diacetyldiaminodiphenyl sulfoneCI 5564,4'-Diacetylaminodiphenyl sulfone4',4'''-Sulfonylbis(acetanilidec)CI-556N,N'-(Sulfonyldi-4,1-phenylene)bisacetamideN,N'-Diacetyl-4,4'-diaminodiphenyl sulfoneNSC-218125
Datenbank-Bezeichner
- CAS
77-46-3- PubChem CID
- 6477
- DTXSID
DTXSID1021295- ChEMBL
CHEMBL154166- ChEBI
CHEBI:139474- UNII
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- 1,1
- Polarare Oberfläche (TPSA)
- 101 Ų
- H-Brücken-Donoren
- 2
- H-Brücken-Akzeptoren
- 4
- Frei drehbare Bindungen
- 4
- Schwere Atome
- 23
- Formalladung
- 0
- Komplexität
- 483
Experimentelle und physikochemische Eigenschaften
Collision Cross Section
173.36 Ų [M+Na]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
171.2 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
Physikochemische Eigenschaften
- Schmelzpunkt
- 289 · 289-292°
- Dichte
- 1.2982 · 1.2982 (rough estimate)
- Brechungsindex
- 1.693 · 1.6930 (estimate)
Sicherheit und Regulatorisches
Gefahrenhinweise
Other Safety InformationIMAP assessments - Acetamide, N,N'-(sulfonyldi-4,1-phenylene)bis-: Environment tier I assessment
Chemie und Industrie
Pharmakologische Informationen
MeSH Pharmacological Classification
Substances that prevent infectious agents or organisms from spreading or kill infectious agents in order to prevent the spread of infection.
Agents used in the treatment of malaria. They are usually classified on the basis of their action against plasmodia at different stages in their life cycle in the human. (From AMA, Drug Evaluations Annual, 1992, p1585)
Substances that suppress Mycobacterium leprae, ameliorate the clinical manifestations of leprosy, and/or reduce the incidence and severity of leprous reactions.
Anwendungen
VerwendenAntimalarial; antibacterial (leprostatic).
Vor- und nachgelagerte Produkte
Vorgelagerte Rohstoffe
Anbieter9 Anbieter
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