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Grundinformationen
- CAS
379-68-0- Standard-SMILES
C[C@]12CCC(=O)C=C1CC[C@H]1[C@@H]3CC[C@H](C(=O)CO)[C@@]3(CO)CC[C@@H]12- InChIKey
VPJHREHKRNIYDB-TZGXILGRSA-N- Summenformel
- C21H30O4
- Durchschnittliche Molmasse
- 346,467 g/mol
- Monoisotopische Masse
- 346,21440944
Namen und Bezeichner
- Bevorzugter Name
- 18-Hydroxy-11-deoxycorticosterone
- IUPAC
- 18,21-Dihydroxypregn-4-ene-3,20-dione
- Lokaler Name
- 18,21-Dihydroxypregn-4-en-3,20-dion
- Englischer Name
- 18-HYDROXY-11-DEOXYCORTICOSTERONE
- Summenformel
- C21H30O4
- Molmasse
- 346.46
Namen und Synonyme
18-HYDROXY DOC18-HYDROXYDEOXYCORTICOSTERONE4-PREGNEN-18,21-DIOL-3,20-DIONE4-PREGNENE-18,21-DIOL-3,20-DIONE18-HYDROXY-11-DEOXYCORTICOSTERONE11-DEOXY-18-HYDROXYCORTICOSTERONE18,21-dihydroxypregn-4-ene-3,20-dione18,21-DIHYDROXY-4-PREGNENE-3,20-DIONEPregn-4-ene-3,20-dione, 18,21-dihydroxy-18,20-EPOXY-20,21-DIHYDROXY-4-PREGNEN-3-ONE
Datenbank-Bezeichner
- CAS
379-68-0- PubChem CID
- 64970
- DTXSID
DTXSID90958920- ChEBI
CHEBI:195166- EC Number
- 206-834-3
- Nikkaji
- J117.990J
Eigenschaften
Physikochemische Eigenschaften
- Schmelzpunkt
- 171 · 171-173 °C
- storage temp.
- 2 · 2-8°C
- Löslichkeit
- Chloroform (Slightly, Sonicated), Methanol (Slightly, Heated)
- Aggregatzustand
- Solid
- Farbe
- White to Off-White
- LogP
- 1.571 · 1.571 (est)
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
Sicherheitsdaten
- safety_code
- 22-24/25
Chemie und Industrie
Anwendungen
Beschreibung18-hydroxy-11-deoxy Corticosterone (18-OH-DOC) is a mineralocorticoid secreted by the zona fasciculata of the adrenal gland. Its biosynthesis is regulated by adrenocorticotropic hormone (ACTH; ) as well as angiotensin II , which increases 18-OH-DOC production in isolated human adrenal glomerulosa cells. 18-OH-DOC can be formed via conversion of 11-deoxy corticosterone (DOC; ) in human SK-MEL188 melanoma cells. 18-OH-DOC is an intermediate in the metabolism of progesterone and can be converted to aldosterone by the capsular portion of rat adrenal glands. Continuous infusion of 18-OH-DOC (200 μg/rat per day) increases systolic blood pressure in uninephrectomized saline-drinking rats. Plasma levels of 18-OH-DOC are elevated in a db/db mouse model of type 2 diabetes.
Verwenden11-Deoxy-18-hydroxycorticosterone is an analog of Corticosterone (C695700); a glucocorticoid and intermediate in the biosynthesis of Aldosterone (A514700) which is an adrenocortical steroid isolated from the adrenal cortex.
Anbieter12 Anbieter
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