2',3'-Didehydro-2',3'-dideoxyadenosine
Grundinformationen
- CAS
7057-48-9- Standard-SMILES
Nc1ncnc2c1ncn2[C@H]1C=C[C@@H](CO)O1- InChIKey
JFUOUIPRAAGUGF-NKWVEPMBSA-N- Summenformel
- C10H11N5O2
- Durchschnittliche Molmasse
- 233,23 g/mol
- Monoisotopische Masse
- 233,09127459
Überblick
structure given in first source
Namen und Bezeichner
- Bevorzugter Name
- 2',3'-Didehydro-2',3'-dideoxyadenosine
- IUPAC
- [(2S,5R)-5-(6-aminopurin-9-yl)-2,5-dihydrofuran-2-yl]methanol
- Englischer Name
- 2',3'-Dideoxy-2',3'-didehydroadenosine
- Summenformel
- C10H11N5O2
- Molmasse
- 233.23
Namen und Synonyme
7057-48-92'3'-Didehydro-2'3'-dideoxyadenosine2'3'-Ddda2',3'-Didehydro-2',3'-dideoxyadenosineSK35877HI5RefChem:908366beta-L-D4A2',3'-Dideoxy-2',3'-didehydroadenosine((2S,5R)-5-(6-Amino-9H-purin-9-yl)-2,5-dihydrofuran-2-yl)methanolAdenosine, 2',3'-didehydro-2',3'-dideoxy-[(2S,5R)-5-(6-amino-9H-purin-9-yl)-2,5-dihydrofuran-2-yl]methanol2',3'-Dideoxy-2'3'-didehydroadenosine
Weitere Namen anzeigen
D4ANSC 108602Compound FL0097Didanosin EP Imp I2',3'-Dideoxy-2'3'-didehy...
[(2S,5R)-5-(6-aminopurin-9-yl)-2,5-dihydrofuran-2-yl]methanolDidanosine EP Impurity IMFCD00040965ddeAdoAdenine, 9-(2,3-dideoxy-.beta.-D-glycero-pent-2-enofuranosyl)-UNII-SK35877HI5NSC108602NSC-108602
Datenbank-Bezeichner
- CAS
7057-48-9
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- -0,4
- Polarare Oberfläche (TPSA)
- 99,1 Ų
- H-Brücken-Donoren
- 2
- H-Brücken-Akzeptoren
- 6
- Frei drehbare Bindungen
- 2
- Schwere Atome
- 17
- Formalladung
- 0
- Komplexität
- 313
Physikochemische Eigenschaften
- Schmelzpunkt
- 187 · 187-189°C
- Siedepunkt
- 553.9 · 553.9±60.0 °C(Predicted)
- Dichte
- 1.74 · 1.74±0.1 g/cm3(Predicted)
- storage temp.
- 2 · 2-8°C(protect from light)
- Löslichkeit
- Soluble in DMSO
- pka
- 14.28 · 14.28±0.10(Predicted)
Sicherheit und Regulatorisches
Sicherheitsdaten
- Alarmwort
- Warnung
- Gefahrenhinweise
- Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code H302
Chemie und Industrie
Pharmakologische Informationen
MeSH Pharmacological Classification
Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly.
Inhibitors of reverse transcriptase (RNA-DIRECTED DNA POLYMERASE), an enzyme that synthesizes DNA on an RNA template.
Agents used to treat AIDS and/or stop the spread of the HIV infection. These do not include drugs used to treat symptoms or opportunistic infections associated with AIDS.
Anwendungen
Verwenden2’,3’-Dideoxy-2,3-didehydroadenosine (Didanosine EP Impurity I) is an impurity of Didanosine (D440950), which is a purine analog (1) which used as an antiviral agent. Classed as an anti-retroviral drug used in the treatment of HIV in ART therapy, it also may increase acetaminophen related hepatotoxicity by enhancing mitochrondrial dysfunction (2).
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广州隽沐生物科技股份有限公司020-36607679; 13502246435 · [email protected]
苏州启航生物科技有限公司18151111370 · [email protected]
Suzhou ARTK Medchem Co., Ltd.+86-18168183658 · [email protected]
广州隽唐科技有限公司
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