HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HCID 64985Erstellt: 3. November 2026
Ccris 6292
PROSTRATIN · SA 101A · NSC 623310 · CCRIS 6292 · Prostatin >99% · Stillingia Facto · Prostratin[P0077] · 13-O-Acetylphorbol
https://huagongshe.com/de/chemical/64985
Identifikatoren & physikalische Daten
| CAS No. | 60857-08-1 |
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| Summenformel | C22H30O6 |
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| Durchschnittliche Molmasse | 390,5 g/mol |
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| Monoisotopische Masse | 390,20423867 g/mol |
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| SMILES | CC(=O)OC12C[C@@H](C)[C@@]3(O)[C@@H](C=C(CO)C[C@]4(O)C(=O)C(C)=C[C@@H]34)C1C2(C)C |
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| InChIKey | BOJKFRKNLSCGHY-KKFGZBDXSA-N |
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| PubChem CID | 64985 |
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| DTXSID | DTXSID10893788 |
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Chemische & physikalische Eigenschaften
| XLogP | 0,7 |
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| Polarare Oberfläche (TPSA) | 104 |
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| H-Brücken-Donoren | 3 |
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| H-Brücken-Akzeptoren | 6 |
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| Frei drehbare Bindungen | 3 |
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| Schwere Atome | 28 |
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| Formalladung | 0 |
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| Komplexität | 825 |
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| Schmelzpunkt | 216-219℃ |
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| Siedepunkt | 550.5±50.0 °C(Predicted) |
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| Dichte | 1.31 |
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| Lagerbedingungen | -20°C |
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| Löslichkeit | Soluble in DMSO at 30mg/ml |
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| Aggregatzustand | white powder |
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| pKa (Säurekonstante) | 11.40±0.70(Predicted) |
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| Farbe | Off-white |
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| Stabilität | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
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| InChIKey | BOJKFRKNLSCGHY-HXGSDTCMSA-N |
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| SMILES | C[C@@H]1C[C@]2(OC(C)=O)[C@H]([C@@H]3C=C(CO)C[C@@]4(O)[C@@H](C=C(C)C4=O)[C@@]13O)C2(C)C |
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Sicherheit & Vorschriften
| Wassergefährdungsklasse (WGK) | 3 |
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| Zollcode | 2916200090 |
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| Lagerklasse | 11 - Combustible Solids |
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Anwendungen & Verwendung
Beschreibung
Activation of latent reservoirs of HIV-infected cells is a treatment strategy designed to reduce viral load and eliminate the perpetuation of retroviral infection. Prostratin is a non-tumor promoting phorbol ester that potently induces HIV-1 reactivation in latent reservoirs of infected Jurkat-LAT-GFP cells with an IC50 value of ~0.5 μM. Originally, prostratin was isolated from plant sources including P. prostrata, E. cornigera, and H. nutans. The effects of prostratin are mediated through activation of NF-κB via protein kinase C and by downregulation of HIV-1 receptor CD4 expression and its co-receptors CXCR4 and CCR5.
