6-Azacytidine
Grundinformationen
- CAS
3131-60-0- Standard-SMILES
Nc1cnn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)n1- InChIKey
OZQDLJNDRVBCST-SHUUEZRQSA-N- Summenformel
- C8H12N4O5
- Durchschnittliche Molmasse
- 244,2 g/mol
- Monoisotopische Masse
- 244,0807695
Überblick
6-azacytidine is a white crystalline powder. (NTP, 1992)
Namen und Bezeichner
- Bevorzugter Name
- 6-Azacytidine
- IUPAC
- 5-amino-2-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,4-triazin-3-one
- Englischer Name
- 6-AZACYTIDINE
- Summenformel
- C8H12N4O5
- Molmasse
- 244.2
Namen und Synonyme
6-Azacytidine3131-60-0DTXSID4020117YD42UEH51C5-Amino-2-beta-D-ribofuranosyl-1,2,4-triazin-3(2H)-oneDTXCID40117as-Triazin-3(2H)-one, 5-amino-2-beta-D-ribofuranosyl-NSC-5247671,2,4-Triazin-3(2H)-one, 5-amino-2-beta-D-ribofuranosyl-RefChem:1042315-AMINO-1,2,4-TRIAZIN-3-ONE 2-BETA-D-RIBOFURANOSIDE5-amino-2-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,4-triazin-3-one
Weitere Namen anzeigen
5-Amino-2-β-D-ribofuranosyl-1,2,4-triazin-3(2H)-one4-triazin-3(2h)-one,5-amino-2-beta-d-ribofuranosyl-21,2,4-Triazin-3(2H)-one, 5-amino-2-β-D-ribofuranosyl-2-(β-D-Ribofuranosyl)-5-amino-1,2,4-triazine-3(2H)-one
6-Azacytidine (VAN)5-amino-2-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1,2,4-triazin-3-oneCCRIS 67426-Azacytosine ribosideUNII-YD42UEH51CNSC 524767as-Triazin-3(2H)-one, 5-amino-2beta-D-ribofuranosyl-1,2,4-Triazin-3(2H)-one, 5-amino-2beta-D-ribofuranosyl
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- -2,5
- Polarare Oberfläche (TPSA)
- 141 Ų
- H-Brücken-Donoren
- 4
- H-Brücken-Akzeptoren
- 6
- Frei drehbare Bindungen
- 2
- Schwere Atome
- 17
- Formalladung
- 0
- Komplexität
- 384
Experimentelle und physikochemische Eigenschaften
Physical Description6-azacytidine is a white crystalline powder. (NTP, 1992)
Physikochemische Eigenschaften
- Schmelzpunkt
- 215 °C · 215 °C
- Siedepunkt
- 387.12 °C · 387.12°C (rough estimate)
- Dichte
- 1.4287 · 1.4287 (rough estimate)
- Brechungsindex
- 1.659 · 1.6590 (estimate)
- pka
- 13.44 · 13.44±0.70(Predicted)
- EPA chemische Informationen
- 6 · 6-Azacytidine (3131-60-0)
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
Warning
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
P264, P270, P280, P301+P317, P302+P352, P317, P321, P330, P362+P364, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 39 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Gefahrenhinweise
Fire HazardsFlash point data for this chemical are not available. It is probably combustible. (NTP, 1992)
Health HazardsSYMPTOMS: Symptoms of exposure to related compounds include nausea, vomiting, diarrhea and mylagia.
Reactive GroupAlcohols and Polyols
Reactivity Profile
6-AZACYTIDINE is an organic compound with both amine and alcohol substituents. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.
Air and Water ReactionsThis chemical may be light and air sensitive.
Hazard Classes and CategoriesAcute Tox. 4 (100%)
Sicherheit und Schutzausrüstung
Chemie und Industrie
Anbieter4 Anbieter
上海梅凯科技有限公司021-68689288 15300790979 · [email protected]
重庆福腾医药有限公司18696571988 · [email protected]
杭州六可生物科技有限公司+86-571-86912261 19975279805 · [email protected]
DAYANG CHEM (HANGZHOU) CO.,LTD+86-88938639 +86-17705817739 · [email protected]
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