Brl 43694A
Grundinformationen
- CAS
107007-99-8- Standard-SMILES
CN1C2CCCC1CC(NC(=O)c1nn(C)c3ccccc13)C2.Cl- InChIKey
QYZRTBKYBJRGJB-UHFFFAOYSA-N- Summenformel
- C18H25ClN4O
- Durchschnittliche Molmasse
- 348,9 g/mol
- Monoisotopische Masse
- 348,1716891
Überblick
See also: Granisetron Hydrochloride (annotation moved to).
Namen und Bezeichner
- Bevorzugter Name
- Brl 43694A
- IUPAC
- 1-methyl-N-(9-methyl-9-azabicyclo[3.3.1]nonan-3-yl)indazole-3-carboxamide;hydrochloride
- Englischer Name
- Granisetron Hydrochloride
- Summenformel
- C18H24N4O.ClH
- Molmasse
- 348.87
Namen und Synonyme
BRL 43694ABRL-43694ARefChem:917581Granisetron HClGranisetron hydrochloride107007-99-8Bema granisetronGranistron hydrochlorideGranisetron Impurity C57Granisetron (Hydrochloride)C18H25ClN4OGranisetron (as hydrochloride)
Weitere Namen anzeigen
KYTRILGranisetron hydrocholride1-Methyl-N-[(1β,3α,5β)-9-methyl-9-azabicyclo[3.3.1]nonane-3-yl]-1H-indazole-3-carboxamide·hydrochlorideKitrylGransetron HClGranisetronBasemidehydrochloride
Pharmakon1600-01502365s13451-methyl-N-(9-methyl-9-azabicyclo[3.3.1]nonan-3-yl)indazole-3-carboxamide;hydrochlorideNSC-7598391-Methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-1H-indazole-3-carboxamide hydrochloride1044956-47-91-Methyl-N-(9-methyl-9-azabicyclo[3.3.1]non-3-yl)-1H-indazole-3-carboxamide hydrochloride1-Methyl-N-(9-methyl-9-azabicyclo[3.3.1]nonan-3-yl)-1H-indazole-3-carboxamide hydrochloride
Datenbank-Bezeichner
- CAS
107007-99-8
Eigenschaften
Berechnete Struktureigenschaften
- Polarare Oberfläche (TPSA)
- 50,2 Ų
- H-Brücken-Donoren
- 2
- H-Brücken-Akzeptoren
- 3
- Frei drehbare Bindungen
- 2
- Schwere Atome
- 24
- Formalladung
- 0
- Komplexität
- 442
Physikochemische Eigenschaften
- Schmelzpunkt
- 290 · 290-292°C
- storage temp.
- Room temp
- Löslichkeit
- 2 O: · H2O: >10mg/mL
- Aggregatzustand
- solid
- Farbe
- white to off-white
- Merck
- 14 · 14,4536
- Major Application
- pharmaceutical (small molecule)
- InChI
- InChI=1/C18H24N4O.ClH/c1-21-13-6-5-7-14(21)11-12(10-13)19-18(23)17-15-8-3-4-9-16(15)22(2)20-17;/h3-4,8-9,12-14H,5-7,10-11H2,1-2H3,(H,19,23);1H/t12-,13+,14-;
- InChIKey
- QYZRTBKYBJRGJB-WQTKJZBYNA-N
- SMILES
- C12C=CC=CC=1N(C)N=C2C(=O)N[C@@H]1C[C@@]2([H])N(C)[C@]([H])(CCC2)C1.Cl |&1:13,15,19,r|
- CAS Datenbank
- 107007 · 107007-99-8(CAS DataBase Reference)
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
Sicherheitsdaten
- wgk
- 3
- hs_code
- 29399990
- RTECS-Nr.
- NK7882200
- risk_code
- 22-62-37/38-36/37/38-36
- hazard_code
- Xn,Xi
- safety_code
- 26-36-37-24/25
- Speicherklasse
- 11 - Combustible Solids
- Hazard Classifications
- Acute Tox. 4 Oral
Chemie und Industrie
Pharmakologische Informationen
MeSH Pharmacological Classification
Drugs used to prevent NAUSEA or VOMITING.
Drugs that bind to but do not activate SEROTONIN 5-HT3 RECEPTORS, thereby blocking the actions of SEROTONIN or SEROTONIN 5-HT3 RECEPTOR AGONISTS.
Anwendungen
BeschreibungGranisetron hydrochloride is the second selective 5HT-3-antagonist approved for the management of nausea and vomiting induced by cancer chemotherapy.Like ondansetron, granisetron hydrochloride is superior to metoclopramide in both efficacy and side effect profile. The compound appears to be effective both as a prophylactic agent and in blocking vomiting once started.
VerwendenA specific serotonin (5HT3) receptor antagonist. Used as an antiemetic. Granisetron HCl is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemothera py. Its main effect is to reduce the activity of the vagus nerve. It does not have much effect on vomiting due to motion sickness. This drug does not have any effect on dopamine receptors or muscarini c receptor
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