Tri-p-tolylphosphat

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Tricresyl phosphates should be stored in a cool, well ventilated area, protected from direct sunlight and away from open flames. Containers should be made of galvanized steel; these should be effectively sealed and their contents clearly marked. Tricresyl phosphates should not be used in plastic articles which are likely to come into contact with foodstuffs or clothing. /Tricresyl phosphates/

SMALL SPILLS AND LEAKAGE: If you spill this chemical, you should dampen the solid spill material with methanol, then transfer the dampened material to a suitable container. Use absorbent paper dampened with methanol to pick up any remaining material. Your contaminated clothing and the absorbent paper should be sealed in a vapor tight plastic bag for eventual disposal. Solvent-wash contaminated surfaces with methanol followed by washing with a strong soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal and plant life; and conformance with environmental and public health regulations.

Absorb with paper towels. Place in a plastic bag. Burn in an open pan with help of flammable solvent or in a furnace. /Tricresyl phosphate/

Prolonged skin or mucous membrane contact should be avoided by use of mechanized processes, protective clothing (including gloves and goggles) and barrier creams; in addition, scrupulous personal hygiene should be encouraged ... . /Tricresyl phosphates/

Where a process entails the heating of tricresyl phosphate, exhaust ventilation should be installed to collect vapors at source or, under special circumstances, workers may be required to wear respiratory protective equipment; a high standard of general ventilation for the workplace is also necessary, and atmospheric determinations should be carried out at regular intervals to ensure that the concentration of tri-o-cresyl phosphate in air is maintained below recommended permissible levels. /Tricresyl phosphates/

Workers should not be allowed to eat, drink or smoke at the workplace. /Tricresyl phosphates/

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

... Ingestion must be prevented & breathing of vapors must not be continuous ... . Isomeric mixt/

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

Wear safety glasses, gas mask, long-sleeve coveralls with tight collars and cuffs, gloves, and boots. /Tricresyl phosphate/

Respiratory protection (supplied-air respirator with full facepiece or self-contained breathing apparatus) should be available where these compounds are manufactured or used and should be worn in case of emergency and overexposure. /Phosphorus compounds/

TERRESTRIAL FATE: Based on a recommended classification scheme(1), an estimated Koc value of 4.4X10+4(SRC), determined from a structure estimation method(2), indicates that tri-p-cresyl phosphate is expected to be immobile in soil(SRC). Volatilization of tri-p-cresyl phosphate from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 5.4X10-8 atm-cu m/mole(SRC), using a fragment constant estimation method(2). Tri-p-cresyl phosphate is not expected to volatilize from dry soil surfaces based on an estimated vapor pressure of 4.9X10-7 mm Hg(SRC), determined from a fragment constant method(2). Biodegradation of tri-p-cresyl phosphate in soil is expected to be an important fate process(SRC), based on its ready biodegradability in water and sediments(3-6).

AQUATIC FATE: Based on a recommended classification scheme(1), an estimated Koc value of 4.4X10+4(SRC), determined from a structure estimation method(2), indicates that tri-p-cresyl phosphate is expected to adsorb to suspended solids and sediment in water(SRC). Tri-p-cresyl phosphate has been observed to adsorb to sediment in the water column and precipitate to the bottom in sorption studies(3). Volatilization from water surfaces is not expected(4) based upon an estimated Henry's Law constant of 5.4X10-8 atm-cu m/mole(SRC), developed using a fragment constant estimation method(2). According to a classification scheme(5), a BCF range of 928 to 1589 measured in fathead minnows, rainbow trout, and bluegills(6) suggests bioconcentration in aquatic organisms is high to very high(SRC). A base-catalyzed second-order hydrolysis rate constant of 0.068 L/mole-sec(SRC) and a neutral hydrolysis rate constant 1.18X10-7/day(SRC) were estimated using a structure estimation method(2); this corresponds to half-lives of 3.2 years, 118 days, 11.8 and 1.18 days at pH values of 7, 8, 9 and 10, respectively(2). The half-life of tri-p-cresyl phosphate in lake water, river water and sediment bottoms has been observed to range from 2 to 5.3 days(7,8). Tri-p-cresyl phosphate was readily biodegradable in sewage treatment and activated sludge studies(9,10).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), tri-p-cresyl phosphate, which has an estimated vapor pressure of 4.9X10-7 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase tri-p-cresyl phosphate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 1.2 days(SRC), calculated from its rate constant of 1.4X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(2). Monitoring studies have observed that tri-p-cresyl phosphate is removed from the atmosphere by both wet and dry deposition(3). Tri-p-cresyl phosphate does not absorb UV wavelengths >290 nm(4) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC).

Reproductive Toxin - A chemical that is toxic to the reproductive system, including defects in the progeny and injury to male or female reproductive function. Reproductive toxicity includes developmental effects. See Guidelines for Reproductive Toxicity Risk Assessment.

/AQUATIC SPECIES/ Rainbow trout (Salmo gairdneri) were exposed to IMOL S-140, a synthetic high-temperature lubricating oil composed of tri-aryl phosphates and, although no sign of acute toxicity was evident, the fish slowly developed symptoms of chronic posioning. Thus, floating food pellets were refused, the activities of glutamic oxalacetic transaminase and lactate dehydrogenase in serum were greatly elevated, and internal fatty tissues became discoloured. Neither serum nor brain cholinesterase activities were inhibited. /Triaryl Phosphates/

The average concentration of tri-p-cresyl phosphate in wastewater discharged from industrial machinery complex into the Kurose River, Hiroshima, Japan was 0.01 ug/L(1). The average concentration of tri-p-cresyl phosphate in domestic wastewater from Hiroshima, Japan was 0.01 ug/L(1).

Using a structure estimation method based on molecular connectivity indices(1), the Koc for tri-p-cresyl phosphate can be estimated to be 4.4X10+4(SRC). According to a recommended classification scheme(2), this estimated Koc value suggests that tri-p-cresyl phosphate is expected to be immobile in soil(SRC). Tri-p-cresyl phosphate was found to adsorb strongly to clay minerals in sorption tests(3). Using bottom sediment from a river, tri-p-cresyl phosphate was found to adsorb strongly to the sediment with a Freundlich isotherm constant of 138(4); it was further observed that tri-p-cresyl phosphate in the water column adsorbed to sediment and precipitated to the bottom(4).

... TRITOLYL PHOSPHATE CONCN IN AIR OF FACTORY WHERE 3 CASES OF POLYNEURITIS OCCURRED ... & VARIOUS SAMPLES TAKEN IN THIS ATMOSPHERE SHOWED CONCN BETWEEN 0.55 MG/CU M & 1.66 MG/CU M. /ISOMERIC MIXT/

URBAN/SUBURBAN: Tri-p-cresyl phosphate concentrations of 0.003 to 0.029 ng/cu m were detected in atmospheric samples collected from the Kurose river basin, Higoshi-Hiroshima city, Japan during 1995 monitoring(1).

/SIGNS AND SYMPTOMS/... CHRONIC TOXICITY OF TRITOLYL PHOSPHATE, WHEN THERE WAS SIMULTANEOUS INHALATION & CUTANEOUS ABSORPTION. MAIN SYMPTOMS WERE HYPERHYDROSIS, HYPOTENSION, GENERAL FATIGUE, AFFECTIVE IRRITABILITY, & PARESTHESIA IN LIMBS. /ISOMERIC MIXT/

/SIGNS AND SYMPTOMS/ NONE OF USUAL TOXIC EFFECTS OF CRESOLS OR PHENOLS IS DESCRIBED IN CLINICAL POISONINGS. DOES NOT PRODUCE TYPICAL SYNDROME ASSOC WITH CHOLINESTERASE INHIBITION AS DO PHOSPHATE ESTERS LIKE PARATHION. META & PARA ISOMERS ARE RELATIVELY INACTIVE. /O-TRICRESYL PHOSPHATE/

/SIGNS AND SYMPTOMS/... ABSORPTION OF TRITOLYL PHOSPHATE THROUGH SKIN GIVES RISE ONLY TO ATTACK ON PERIPHERAL NERVES, WHILE BREATHING VAPORS IS FOLLOWED, IN PARTICULAR, BY ATTACK ON PYRAMIDAL TRACT. /ISOMERIC MIXT/

/CASE REPORTS/ CASE OF PERMANENT PARALYSIS IN MAN ENGAGED IN MANUFACTURING META & PARA ISOMERS OF TRICRESYL PHOSPHATE ... FINAL PRODUCT CONTAINED ONLY 1% TOCP, AS MUCH AS 6 TO 10% WAS PRESENT AS CONTAMINANT DURING MANUFACTURING. ... PATIENT HAD WORKED ... 5 MO ... BEFORE SYMPTOMS OF ANOREXIA, NAUSEA, & ACHING OF LEGS HAD DEVELOPED.

For more Human Toxicity Excerpts (Complete) data for TRI-P-CRESYL PHOSPHATE (6 total), please visit the HSDB record page.

Tri-p-cresyl phosphate's production and use as a plasticizer in vinyl plastic manufacture, as a flame retardant, gasoline additive, heat exchange medium, solvent for nitrocellulose, and in hydraulic fluids(1,2) may result in its release to the environment through various waste streams(SRC). Rainfall and runoff from agricultural plastic films has been identified as a source of environmental release of tricresyl phoshates(3,4). Tri-p-cresyl phosphate has been detected in gasoline automobile exhaust(5).

AEROBIC: Biodegradation of tri-p-cresyl phosphate in river water and bottom sediment followed first-order kinetics(1). The first-order rate constant in river water ranged from approximately 0.0073 per hour at 14 °C to 0.0091 per hour at 25 °C(1); this corresponds to a half-life of about 4 days at 14 °C and 3.2 days at 25 °C(SRC). The first-order rate constant in bottom sediment ranged from approximately 0.0043 per hour at 14 °C to 0.0055 per hour at 25 °C(1); this corresponds to a half-life of about 6.7 days at 14 °C and 5.3 days at 25 °C(SRC). The half-life of tri-p-cresyl phosphate in Lake Ontario water, following a lag period of 2 days, was 2 days(2). In a laboratory model sewage treatment system 70 to 80% of methyl C-14 tri-p-cresyl phosphate added at 1 ug/ml was degraded in 24 hours using an activated sludge seed; the major metabolite was identified as p-hydroxybenzoic acid(3). In biodegradation tests using an activated sludge seed, tri-p-cresyl phosphate was observed to be biodegradable(4).

Tricresyl phosphate, unspecified isomer, was detected in Detroit river sediments at concentrations ranging from 0.23 to 1.30 ug/L(1). Tri-p-cresyl phosphate was detected in bottom sediment from the Kurose River, Japan at concentrations ranging from 0.003 ug/g in April 1992 to 0.03 ug/g in July 1992(1).

Pursuant to section 8(d) of TSCA, EPA promulgated a model Health and Safety Data Reporting Rule. The section 8(d) model rule requires manufacturers, importers, and processors of listed chemical substances and mixtures to submit to EPA copies and lists of unpublished health and safety studies. Phosphoric acid, tris(4-methylphenyl) ester is included on this list. Effective date: 10/4/82; Sunset date: 10/4/92.

Used as flame retardant; [HSDB] Used in isomeric mixture known as Tricresyl phosphate (CAS # 1330-78-5);

Plasticizer in vinyl plastics manufacture, flame-retardant, solvent for nitrocellulose, in cellulosic molding compositions, as additive to extreme pressure lubricants, non-flammable fluid in hydraulic systems, as lead scavenger in gasoline, to sterilize certain surgical instruments /Isomeric mixture/

Aryl phosphates such as tricresyl phosphate ... when added in small percentages to the gasoline, combat misfires. /Aryl phosphates/

The commercial tricresyl phosphate product is essentially a meta, para-isomer mixture. Tricresyl phosphate is used in flexible PVC, cellulose nitrate, ethylcellulose coatings, and various rubbers. Typical applications are vinyl tarpaulins, mine conveyer belts, air ducts, cable insulation, and vinyl films ... usually used in blends with phthalates.

(1972) NEGLIGIBLE

(1975) 6.82X10+7 GRAMS (PRINCPL CUSTMS DISTS)

Prepared from cresol and phosphorus oxychloride, phosphoric acid, or phosphorus pentachloride. The grades of cresol commonly used are the isomeric (o-, m-, p-), and meta-para mixtures from coal tar and cresylic acid from petroleum. Purification of the product is based on the intended use; the commercial product is generally obtained as a mixture. A "refined grade" of tricresyl phosphate is prepared by vacuum distillation, or alternatively by washing with 2% sodium hydroxide and water ... . /Tricresyl phosphate/

Phosphoric acid, tris(4-methylphenyl) ester: ACTIVE

TRICRESYL PHOSPHATE SHOULD NOT BE USED IN PLASTIC ARTICLES WHICH ARE LIKELY TO COME INTO CONTACT WITH FOODSTUFFS OR CLOTHING. /ISOMERIC MIXT/

A tricresyl phosphate prepared from m- or p-cresol has the same properties as the technical product, but the cost of separating and purifying these isomers is prohibitive. /Isomeric mixt/

... A) ARYL PHOSPHATES ... NOT SUITABLE FOR PLASTICS IN CONTACT WITH FOODSTUFFS; C) ... SHOULD NOT BE USED IN ARTICLES INTENDED FOR WEAR DIRECTLY ON SKIN OR ARTICLES ... HANDLED BY CHILDREN. /ARYL PHOSPHATES/

The commercial tricresyl phosphate product is essentially a meta, para-isomer mixture.