HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
N,N-Dimethyl-3-((1-(phenylmethyl)-1H-indazol-3-yl)oxy)-1-propanamin-monohydrochlorid
BENZYDAMINE HCL · af864 · tamas · verax · tantum · riripen · ririlim · indolin
Identifikatoren & physikalische Daten
| CAS No. | 132-69-4 |
|---|---|
| Summenformel | C19H24ClN3O |
| Durchschnittliche Molmasse | 345,9 g/mol |
| Monoisotopische Masse | 345,16079007 g/mol |
| SMILES | CN(C)CCCOc1nn(Cc2ccccc2)c2ccccc12.Cl |
| InChIKey | HNNIWKQLJSNAEQ-UHFFFAOYSA-N |
| PubChem CID | 65464 |
| ChEMBL | CHEMBL1528134 |
| ChEBI | CHEBI:31266 |
| EC No. | 205-076-0 |
| DTXSID | DTXSID1045293 |
| Lokaler Name | N,N-Dimethyl-3-((1-(phenylmethyl)-1H-indazol-3-yl)oxy)-1-propanamin-monohydrochlorid |
Chemische & physikalische Eigenschaften
| Polarare Oberfläche (TPSA) | 30,3 |
|---|---|
| H-Brücken-Donoren | 1 |
| H-Brücken-Akzeptoren | 3 |
| Frei drehbare Bindungen | 7 |
| Schwere Atome | 24 |
| Formalladung | 0 |
| Komplexität | 344 |
| Stoffklassen | Other Uses -> Pharmaceuticals |
| Löslichkeit | 22.5 [ug/mL] (The mean of the results at pH 7.4)Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)Soluble in water, ethanol, chloroform, n-butanol or DMSO /n |
| Collision Cross Section | 170.9 Ų [M+H]+ [CCS Type: TWMethod: calibrated with polyalanine and drug standards] |
| Schmelzpunkt | 147-153°C |
| Lagerbedingungen | Inert atmosphere,2-8°C |
| Aggregatzustand | Solid |
| Farbe | White to Off-White |
| Merck | 14,1122 |
| Hauptanwendungen | forensics and toxicologypharmaceutical (small molecule)veterinary |
| InChI | InChI=1S/C19H23N3O.ClH/c1-21(2)13-8-14-23-19-17-11-6-7-12-18(17)22(20-19)15-16-9-4-3-5-10-16/h3-7,9-12H,8,13-15H2,1-2H31H |
| InChIKey | HNNIWKQLJSNAEQ-UHFFFAOYSA-N |
| SMILES | C12C=CC=CC=1C(=NN2CC1C=CC=CC=1)OCCCN(C)C.Cl |
| CAS Datenbank | 132-69-4(CAS DataBase Reference) |
Sicherheit & Vorschriften
| GHS-Einstufung | WarningH302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]P264, P264+P265, P270, P280, P301+P317, P305+P351+P338, P330, P337+P317, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 105 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| Weitere Sicherheitsinformationen | IMAP assessments - 1-Propanamine, N,N-dimethyl-3-[[1-(phenylmethyl)-1H-indazol-3-yl]oxy]-, monohydrochloride: Environment tier I assessment |
| Gefahrenübersicht | Allergic and photoallergic contact dermatitis reported[Kanerva, p. 1757] |
| Hazard Classes and Categories | Acute Tox. 4 (100%) |
| Unerwünschte Wirkungen | Dermatotoxin - PACD (photoallergic contact dermatitis). |
| Wassergefährdungsklasse (WGK) | 3 |
| Zollcode | 2933.99.8290 |
| RTECS-Nr. | NK7875000 |
| R-Sätze (R) | 20/21/22-36 |
| Toxizität | LD50 in mice, rats (mg/kg): 110, 100 i.p.515, 1050 orally (Silvestrini) |
| Gefahrensymbole | Xn |
| Sicherheitshinweise (S) | 26-36 |
| Lagerklasse | 11 - Combustible Solids |
| Gefahrenklasse | Acute Tox. 4 OralEye Irrit. 2 |
Anwendungen & Verwendung
Beschreibung
Benzydamine hydrochloride is a non-steroidal antiinflammatory drug used both topically and systemically. It has been reported as a sensitizer and a photosensitizer and caused occupational contact dermatitis in a nurse.
Verwenden
Benzydamine hydrochloride is an anti-in-flammatory drug used extensively in Europe and recently introduced in Canada to help re duce painful mucositis. Benzydamine provides short-term topical anesthesia and extended pain relief apparently through its anti-inflammatory properties. Studies have shown it to be effective in a range of painful conditions, including aphthous ulceration, chemotherapy-induced mucositis, and radiation-induced mucositis.