N,N-Dimethyl-3-((1-(phenylmethyl)-1H-indazol-3-yl)oxy)-1-propanamin-monohydrochlorid

Benzydamine Hydrochloride

HCID 65464CAS 132-69-4
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Grundinformationen

Standard-SMILES
CN(C)CCCOc1nn(Cc2ccccc2)c2ccccc12.Cl
InChIKey
HNNIWKQLJSNAEQ-UHFFFAOYSA-N
Summenformel
C19H24ClN3O
Durchschnittliche Molmasse
345,9 g/mol
Monoisotopische Masse
345,16079007

Überblick

Benzydamine hydrochloride is a member of indazoles.

Namen und Bezeichner

Bevorzugter Name
Benzydamine Hydrochloride
IUPAC
3-(1-benzylindazol-3-yl)oxy-N,N-dimethylpropan-1-amine;hydrochloride
Lokaler Name
N,N-Dimethyl-3-((1-(phenylmethyl)-1H-indazol-3-yl)oxy)-1-propanamin-monohydrochlorid
Englischer Name
Benzydamine hydrochloride
Summenformel
C19H23N3O.ClH
Molmasse
345.87

Namen und Synonyme

Benzydamine hydrochloride132-69-4Benzydamine HClBenzidamine hydrochlorideTantumBenalginDorinaminBenzyrinEpirotinSalyzoronDifflamEnzamin
Weitere Namen anzeigen
af864Afloben
ImotrylIndolinRirilimRiripenTamasVeraxAF 864DTXSID1045293

Datenbank-Bezeichner

CAS
132-69-4
PubChem CID
65464
DTXSID
DTXSID1045293
ChEMBL
CHEMBL1528134
ChEBI
CHEBI:31266
UNII
K2GI407R4Q
EC Number
205-076-0

Eigenschaften

Berechnete Struktureigenschaften

Polarare Oberfläche (TPSA)
30,3 Ų
H-Brücken-Donoren
1
H-Brücken-Akzeptoren
3
Frei drehbare Bindungen
7
Schwere Atome
24

Experimentelle und physikochemische Eigenschaften

Chemical ClassesOther Uses -> Pharmaceuticals
Solubility22.5 [ug/mL] (The mean of the results at pH 7.4)
Collision Cross Section170.9 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

Physikochemische Eigenschaften

Schmelzpunkt
147 · 147-153°C
storage temp.
2 · Inert atmosphere,2-8°C
Löslichkeit
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
Aggregatzustand
Solid
Farbe
White to Off-White
Wasserlöslichkeit
Soluble in water, ethanol, chloroform, n-butanol or DMSO /n

Sicherheit und Regulatorisches

GHS-Klassifizierung

GHS Classification · 4 Einträge

Warning

H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]

P264, P264+P265, P270, P280, P301+P317, P305+P351+P338, P330, P337+P317, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 105 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Gefahrenhinweise

Other Safety InformationIMAP assessments - 1-Propanamine, N,N-dimethyl-3-[[1-(phenylmethyl)-1H-indazol-3-yl]oxy]-, monohydrochloride: Environment tier I assessment
Hazards SummaryAllergic and photoallergic contact dermatitis reported; [Kanerva, p. 1757]
Hazard Classes and CategoriesAcute Tox. 4 (100%)

Toxikologische Informationen

Adverse EffectsDermatotoxin - PACD (photoallergic contact dermatitis).

Sicherheitsdaten

wgk
3
hs_code
2933.99.8290
RTECS-Nr.
NK7875000
risk_code
20/21/22-36
Toxizität
LD50 in mice, rats (mg/kg): 110, 100 i.p.; 515, 1050 orally (Silvestrini)
hazard_code
Xn

Chemie und Industrie

Pharmakologische Informationen

MeSH Pharmacological ClassificationSubstances that reduce or suppress INFLAMMATION.

Verwendung und Herstellung

UsesUsed as a topical, non-steroidal anti-inflammatory drug (NSAID); [Kanerva, p. 1757]
Anwendungen · 2 Einträge

BeschreibungBenzydamine hydrochloride is a non-steroidal antiinflammatory drug used both topically and systemically. It has been reported as a sensitizer and a photosensitizer and caused occupational contact dermatitis in a nurse.

VerwendenBenzydamine hydrochloride is an anti-in-flammatory drug used extensively in Europe and recently introduced in Canada to help re duce painful mucositis. Benzydamine provides short-term topical anesthesia and extended pain relief apparently through its anti-inflammatory properties. Studies have shown it to be effective in a range of painful conditions, including aphthous ulceration, chemotherapy-induced mucositis, and radiation-induced mucositis.

Vor- und nachgelagerte Produkte

Anbieter50 Anbieter

北京华美互利生物化工010-56205725 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
合肥翰刚医药科技有限公司+8618062405514 · [email protected]
INTATRADE GmbH+49 3493/605464 · [email protected]

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