| GHS-Einstufung | WarningH302 (97.5%): Harmful if swallowed [Warning Acute toxicity, oral]P264, P270, P301+P317, P330, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 40 reports by companies from 2 notifications to the ECHA C&L Inventory. |
|---|
| Brandpotenzial | Self extinguishing |
|---|
| Gefahrenübersicht | Causes somnolence in lethal-dose feeding studies of ratsCauses lacrimation, somnolence, and kidney damage in high-dose inhalation studies[RTECS] An irritant and lachrymatorHighly toxic by inhalationTargets blood, kidneys, and CNS[Aldrich MSDS] |
|---|
| Reaktive Gruppe | Ethers |
|---|
| Reactivity Profile | 3,3-BIS(CHLOROMETHYL)OXETANE is a chlorinated ether. |
|---|
| Air and Water Reactions | No rapid reaction with air. No rapid reaction with water. |
|---|
| CERCLA-Meldepflichtmengen | Releases of CERCLA hazardous substances are subject to the release reporting requirement of CERCLA section 103, codified at 40 CFR part 302, in addition to the requirements of 40 CFR part 355. Oxetane, 3,3-bis(chloromethyl)- is an extremely hazardous substance (EHS) subject to reporting requirements when stored in amounts in excess of its threshold planning quantity (TPQ) of 500 lbs. |
|---|
| Hazard Classes and Categories | Acute Tox. 4 (97.5%) |
|---|
| Erste Hilfe | Signs and Symptoms of Oxetane, 3,3-Bis(chloromethyl)- Exposure: Signs and symptoms of acute exposure to oxetane, 3,3-bis(chloromethyl)- may include headache, dizziness, weakness and nausea. Also, irritation of the eyes, skin, respiratory tract may be observed. Esophagus or gastrointestinal tract irritation is possible if ingested. Longer term exposure may lead to allergic hypersensitivity dermatitis or asthma with bronchospasm and wheezing. |
|---|
| Reinigungsverfahren | Purification of waste water from the synthesis of 3,3-di-(chloromethyl) oxycyclobutane.Biological clarification of sewage from production of 3,3-bis(chloromethyl) oxycyclobutane. |
|---|
| Protective Action Criteria (PAC) | 0.18 [mg/m3]2.0 [mg/m3]7.0 [mg/m3] |
|---|
| Personal Protective Equipment (PPE) | For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. (EPA, 1998) |
|---|
| Unerwünschte Wirkungen | Neurotoxin - Other CNS neurotoxin |
|---|
| Non-Human Toxicity Excerpts | A series of oxetanes containing iodomethyl, alkoxymethyl, and alkylaminomethyl groups were synthesized. The toxicity and broncholytic activity of these compounds were determined in mice and cats. Iodo- and alkyloxy-containing oxetanes possessed lower toxicity, and N-containing oxetanes had higher toxicity than 3,3-bis(chloromethyl)oxetane, the initial product of the synthesis. All compounds containing oxetane ring manifested a pronounced broncholytic effect. 3-(Chloromethyl)-3-(butoxymethyl)oxetane, 3,3-bis(propoxymethyl)oxetane, and 3-(chloromethyl)-3-(iodomethyl)oxetane possessed the same broncholytic effect, as that of euphyllin. |
|---|
| Toxicity Data | LC50 (mice) = 200 mg/m3/2h |
|---|
