HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HCID 65663Erstellt: 1. November 2026
Aloxistatin
aloxistatin · E-64D · EST · ep453 · Estate · CS-1622 · oxistatin · NSC694281
https://huagongshe.com/de/chemical/65663
Identifikatoren & physikalische Daten
| CAS No. | 88321-09-9 |
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| Summenformel | C17H30N2O5 |
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| Durchschnittliche Molmasse | 342,4 g/mol |
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| Monoisotopische Masse | 342,21547206 g/mol |
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| SMILES | CCOC(=O)[C@H]1O[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)NCCC(C)C |
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| InChIKey | SRVFFFJZQVENJC-IHRRRGAJSA-N |
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| PubChem CID | 65663 |
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| ChEMBL | CHEMBL63440 |
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| ChEBI | CHEBI:101381 |
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| EC No. | 635-831-3 |
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| DTXSID | DTXSID00904150 |
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Chemische & physikalische Eigenschaften
| XLogP | 2,3 |
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| Polarare Oberfläche (TPSA) | 97 |
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| H-Brücken-Donoren | 2 |
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| H-Brücken-Akzeptoren | 5 |
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| Frei drehbare Bindungen | 11 |
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| Schwere Atome | 24 |
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| Formalladung | 0 |
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| Komplexität | 450 |
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| Schmelzpunkt | 126.2°C |
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| Siedepunkt | 477.88°C (rough estimate) |
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| Dichte | 1.0657 (rough estimate) |
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| Brechungsindex | 1.5800 (estimate) |
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| Lagerbedingungen | -20°C |
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| Löslichkeit | Soluble in DMSO, DMF or ethanol |
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| Aggregatzustand | White solid |
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| pKa (Säurekonstante) | 13.32±0.40(Predicted) |
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| Farbe | Fine needles from EtOH |
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| Biologische Quelle | synthetic (organic) |
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| Stabilität | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. |
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| InChI | 1S/C17H30N2O5/c1-6-23-17(22)14-13(24-14)16(21)19-12(9-11(4)5)15(20)18-8-7-10(2)3/h10-14H,6-9H2,1-5H3,(H,18,20)(H,19,21)/t12-,13-,14-/m0/s1 |
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| InChIKey | SRVFFFJZQVENJC-IHRRRGAJSA-N |
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| SMILES | N([C@@H](CC(C)C)C(=O)NCCC(C)C)C(=O)[C@H]1O[C@@H]1C(=O)OCC |
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Sicherheit & Vorschriften
| GHS-Einstufung | WarningH315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 40 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
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| Hazard Classes and Categories | Skin Irrit. 2 (100%) |
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| Wassergefährdungsklasse (WGK) | 2 |
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| UN-Transportnummer | 3077 |
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| Zollcode | 29242990 |
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| RTECS-Nr. | RR0404300 |
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| R-Sätze (R) | 36/37/38 |
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| Toxizität | cyt-ham:lng 200 mg/L IYKEDH 17,815,86 |
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| Gefahrensymbole | Xi |
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| Sicherheitshinweise (S) | 26-36-24/25 |
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| Lagerklasse | 11 - Combustible Solids |
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Anwendungen & Verwendung
Beschreibung
E-64d is an irreversible, membrane-permeable inhibitor of lysosomal and cytosolic cysteine proteases and has diverse biological activities. It is a synthetic analog of E-64 and prodrug form of E-64c that inhibits calpain and the cysteine proteases cathepsins F, -K, -B, -H, and -L. E-64d (20-200 μM) induces cell cycle arrest at the G2/M phase in A431 human epidermoid carcinoma cells. It inhibits protease-resistant prion protein accumulation in scrapie-infected neuroblastoma cells with an IC50 value of 0.5 μM. E-46d also inhibits entry of vesicular stomatitis virus (VSV) particles pseudotyped with severe acute respiratory syndrome coronavirus (SARS-CoV) or SARS-CoV-2 spike glycoprotein into Vero cells, an effect that is reduced by expression of the serine protease TMPRSS2.
