Grundinformationen
- CAS
22089-22-1- Standard-SMILES
O=P1(N(CCCl)CCCl)OCCCN1CCCl- InChIKey
UMKFEPPTGMDVMI-UHFFFAOYSA-N- Summenformel
- C9H18Cl3N2O2P
- Durchschnittliche Molmasse
- 323,6 g/mol
- Monoisotopische Masse
- 322,017148
Überblick
Trofosfamide is a member of ifosfamides.
Namen und Bezeichner
- Bevorzugter Name
- Trofosfamide
- IUPAC
- N,N,3-tris(2-chloroethyl)-2-oxo-1,3,2λ5-oxazaphosphinan-2-amine
- Lokaler Name
- Trofosfamid
- Englischer Name
- trofosfamide
- Summenformel
- C9H18Cl3N2O2P
- Molmasse
- 323.58
Namen und Synonyme
Trofosfamide22089-22-1IxotenTrophosphamideTrofosfamidTrilophosphamideTrofosfamidaTrofosfamidumA-4828Z 4828H64JRU6GJ0Z-4828
Weitere Namen anzeigen
Ccris 4442Brn 0532530Asta Z 4828Trofosfamide, 10 mM in DMSOTrofosfamide,Bacterial,Inhibitor,inhibit2H-1,3,2-Oxazaphosphorin-2-amine, N,N,3-tris(2-chloroethyl)tetrahydro-, 2-oxide (9ci)3-(2-Chloroethyl)-2-(bis(2-chloroethyl)amino)perhydro-2H-1,3,2-oxazaphosphorine 2-oxide
NSC-109723N,N,3-Tris(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxideN,N-3'-Tris(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine, 2-oxideNSC109723N,N,N'-Tris(2-chloroethyl)-N',O-propylene phosphoric acid ester diamideGenoxal TrofosfamidaRefChem:900655N,N,N'-tris(2-chloroethyl)-N'-O-propylene phosphoric acid ester diamide
Datenbank-Bezeichner
- CAS
22089-22-1、72282-84-9、72282-85-0- PubChem CID
- 65702
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- 1,8
- Polarare Oberfläche (TPSA)
- 32,8 Ų
- H-Brücken-Donoren
- 0
- H-Brücken-Akzeptoren
- 4
- Frei drehbare Bindungen
- 7
- Schwere Atome
- 17
- Formalladung
- 0
- Komplexität
- 265
Experimentelle und physikochemische Eigenschaften
DrugsPharmaceuticals
Physikochemische Eigenschaften
- Schmelzpunkt
- 47 · 47-49°C
- Siedepunkt
- 104 °C · 104°C
- Dichte
- 1.35 · 1.35±0.1 g/cm3(Predicted)
- storage temp.
- -20 °C · -20°C Freezer
- Löslichkeit
- 50 mg/mL; · DMF: 50mg/mL; DMSO: 30mg/mL; Ethanol: 50mg/mL; PBS (pH 7.2): 10mg/mL
- Aggregatzustand
- A crystalline solid
- pka
- -0.46 · -0.46±0.20(Predicted)
- Farbe
- White to off-white
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
Danger
H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]
P203, P260, P264, P270, P273, P280, P301+P316, P318, P319, P321, P330, P405, and P501 (click each P-code to see the statement)
The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
Gefahrenhinweise
Hazard Classes and CategoriesAcute Tox. 3 (100%)
Sicherheitsdaten
- Toxizität
- LD50 i.p. in mice: 212 mg/kg (Brock, Potel)
Chemie und Industrie
Pharmakologische Informationen
ATC Code
L - Antineoplastic and immunomodulating agents
QL - Antineoplastic and immunomodulating agents
MeSH Pharmacological Classification
Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.
Chemical agents that increase the rate of genetic mutation by interfering with the function of nucleic acids. A clastogen is a specific mutagen that causes breaks in chromosomes.
A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA, Drug Evaluations Annual, 1994, p2026)
Verwendung und Herstellung
UsesUse (kg; approx.) in Germany (2009): >25
Anwendungen
VerwendenAntineoplastic; one derivative
Vor- und nachgelagerte Produkte
Vorgelagerte Rohstoffe
Zugehörige Reaktionen
0
Keine Reaktionsaufzeichnungen unter den aktuellen Filterkriterien.
Notizen zur Verbindung
Wird geladen…