HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Thioridazinhydrochlorid
THIORIDAZINE HCL · L-714 · Ridazin · Orsanil · usafsz-3 · USAF SZ-B · Stalleril · NSC 186060
Identifikatoren & physikalische Daten
| CAS No. | 130-61-0 |
|---|---|
| Summenformel | C21H27ClN2S2 |
| Durchschnittliche Molmasse | 407,04 g/mol |
| SMILES | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1ccccc1S2.[Cl-].[H+] |
| InChIKey | NZFNXWQNBYZDAQ-UHFFFAOYSA-N |
| PubChem CID | 657213 |
| Lokaler Name | Thioridazinhydrochlorid |
Chemische & physikalische Eigenschaften
| Schmelzpunkt | 158-1600C |
|---|---|
| Siedepunkt | 230°C (rough estimate) |
| Dichte | 1.1227 (rough estimate) |
| Brechungsindex | 1.5610 (estimate) |
| Lagerbedingungen | 2-8°C |
| Löslichkeit | H2O: soluble250 mg plus 5 ml of solvent, clear, colorless to faintly yellowSoluble in water (75 mM), DMSO (100 mM), chloroform, ethanol, and methanol. |
| Aggregatzustand | Off-white solid |
| Farbe | White to Almost white |
| Merck | 14,9359 |
| InChI | 1S/C21H26N2S2.ClH/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(24-2)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3 |
| InChIKey | NZFNXWQNBYZDAQ-UHFFFAOYSA-N |
| SMILES | Cl.CSc1ccc2Sc3ccccc3N(CCC4CCCCN4C)c2c1 |
| CAS Datenbank | 130-61-0(CAS DataBase Reference) |
| NIST chemische Informationen | Thioridazine hydrochloride(130-61-0) |
| EPA chemische Informationen | 10H-Phenothiazine, 10-[2-(1-methyl-2-piperidinyl)ethyl]-2-(methylthio)-, monohydrochloride (130-61-0) |
Sicherheit & Vorschriften
| Wassergefährdungsklasse (WGK) | 3 |
|---|---|
| UN-Transportnummer | UN 3077 9/PG 3 |
| Zollcode | 2934302300 |
| RTECS-Nr. | SP2275000 |
| R-Sätze (R) | 22-36/37/38-50/53 |
| Gefahrensymbole | Xn,N |
| Sicherheitshinweise (S) | 26-36-60-61 |
| Gefahrenklasse | 9Acute Tox. 4 Oral |
| Lagerklasse | 11 - Combustible Solids |
Anwendungen & Verwendung
Verwenden
Thioridazine hydrochloride has been used as an intercalating agent for analyzing the integrity of double-stranded DNA (dsDNA) using square-wave voltammetry (SWV) techniques. Thioridazine hydrochloride has also been used as a positive control for the inhibition of hepatic enzyme cytochrome P4502D6 (CYP2D6) in human liver microsomes.