HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Promethazinhydrochlorid
PROMETHAZINE HCL · Phena · PHENERGAN · remsed · promine · N,N-Dimethyl-1-(10H-phenothiazin-10-yl)propan-2-amine hydrochloride · dorme · atosil
Identifikatoren & physikalische Daten
| CAS No. | 58-33-3 |
|---|---|
| Summenformel | C17H21ClN2S |
| Durchschnittliche Molmasse | 320,9 g/mol |
| Monoisotopische Masse | 320,1113975 g/mol |
| SMILES | CC(CN1c2ccccc2Sc2ccccc21)N(C)C.[Cl-].[H+] |
| InChIKey | XXPDBLUZJRXNNZ-UHFFFAOYSA-N |
| PubChem CID | 657263 |
| Lokaler Name | Promethazinhydrochlorid |
Chemische & physikalische Eigenschaften
| Polarare Oberfläche (TPSA) | 31,8 |
|---|---|
| H-Brücken-Donoren | 1 |
| H-Brücken-Akzeptoren | 4 |
| Frei drehbare Bindungen | 3 |
| Schwere Atome | 21 |
| Formalladung | 0 |
| Komplexität | 298 |
| Schmelzpunkt | 230-232°C |
| Flammpunkt | 9℃ |
| Lagerbedingungen | 2-8°C |
| Löslichkeit | Very soluble in water, freely soluble in ethanol (96 per cent) and in methylene chloride. |
| Aggregatzustand | Solid |
| Farbe | White to Almost white |
| pH | pH (50g/L, 25℃) : 4.0～6.0 |
| Geruch | Odorless |
| Merck | 14,7786 |
| BRN | 4166397 |
| BCS Class | 1,3 |
| Hauptanwendungen | pharmaceutical (small molecule) |
| InChI | InChI=1S/C17H20N2S.ClH/c1-13(18(2)3)12-19-14-8-4-6-10-16(14)20-17-11-7-5-9-15(17)19/h4-11,13H,12H2,1-3H31H |
| InChIKey | XXPDBLUZJRXNNZ-UHFFFAOYSA-N |
| SMILES | N1(CC(C)N(C)C)C2C=CC=CC=2SC2=CC=CC=C12.Cl |
| CAS Datenbank | 58-33-3(CAS DataBase Reference) |
| EPA chemische Informationen | Promethazine hydrochloride (58-33-3) |
Sicherheit & Vorschriften
| Wassergefährdungsklasse (WGK) | 3 |
|---|---|
| TSCA-Inventar-Status | TSCA listed |
| UN-Transportnummer | UN 2811 6.1/PG 3 |
| Zollcode | 29343000 |
| RTECS-Nr. | SO8225000 |
| R-Sätze (R) | 22-36/37/38-51/53-43-20/22 |
| Toxizität | LD50 i.v. in mice: 55.0 mg/kg (Rajsner) |
| Gefahrensymbole | Xn,N |
| Sicherheitshinweise (S) | 26-36-61-60-36/37/39-28-22 |
| Gefahrenklasse | 6.1(b)Acute Tox. 4 OralAquatic Chronic 2Eye Dam. 1Skin Sens. 1 |
| Verpackungsgruppe | III |
| Lagerklasse | 11 - Combustible Solids |
Anwendungen & Verwendung
Verwenden
Promethazine hydrochloride is used as antihistamine; antiemetic; central nervous system depressant; sedative; anticholinergic; antiserotoninergic; local anesthetic; in the treatment of motion sickness, cough linctuses, nausea, and allergic conditions; used to control Parkinsonian symptoms and as central nervous system depressant; in pills, syrup, injections and suppositories.