3-Ethyldihydro-4-((1-methyl-1H-imidazol-5-yl)-methyl)-2(3H)-furanon-mononitrat, (3S-cis)-

Pilocarpine Nitrate

HCID 657349CAS 148-72-1
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Grundinformationen

Standard-SMILES
CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C.O=[N+]([O-])O
InChIKey
PRZXEPJJHQYOGF-GNAZCLTHSA-N
Summenformel
C11H17N3O5
Durchschnittliche Molmasse
271,27 g/mol
Monoisotopische Masse
271,11682064

Überblick

See also: Pilocarpine (has active moiety); Pilocarpine Hydrochloride (related).

Namen und Bezeichner

Bevorzugter Name
Pilocarpine Nitrate
IUPAC
(3S,4R)-3-ethyl-4-[(3-methylimidazol-4-yl)methyl]oxolan-2-one;nitric acid
Lokaler Name
3-Ethyldihydro-4-((1-methyl-1H-imidazol-5-yl)-methyl)-2(3H)-furanon-mononitrat, (3S-cis)-
Englischer Name
Pilocarpine nitrate
Summenformel
C11H17N3O5
Molmasse
271.27

Namen und Synonyme

Pilocarpine nitrate148-72-1PilaganPilocarpine mononitratePilocarpini nitrasPilocarpinum nitricumPilocarpine subnitrateNSC-757282M20T465H6JPilocarpine nitrate (USP)Pilocarpine nitrate [USP]2(3H)-Furanone, 3-ethyldihydro-4-((1-methyl-1H-imidazol-5-yl)methyl)-, (3S-cis)-, mononitrate
Weitere Namen anzeigen
NitratPilocarpine nitrate for system suitability CRSPilocarpinnitratEinecs 205-723-7Pilocarpin Nitratep.v.carpineliquifilm
2(3H)-Furanone, 3-ethyldihydro-4-((1-methyl-1H-imidazol-5-yl)methyl)-, (3S,4R)-, mononitratePiloc nitRefChem:863282205-723-7Pilocarpine (nitrate)PilofrinPilocarpine nitrate salt(3S,4R)-3-Ethyl-4-((1-methyl-1H-imidazol-5-yl)methyl)dihydrofuran-2(3H)-one nitrate

Datenbank-Bezeichner

CAS
148-72-1
PubChem CID
657349
DTXSID
DTXSID80883277
ChEMBL
CHEMBL1213136
UNII
M20T465H6J
EC Number
205-723-7

Eigenschaften

Berechnete Struktureigenschaften

Polarare Oberfläche (TPSA)
110 Ų
H-Brücken-Donoren
1
H-Brücken-Akzeptoren
6
Frei drehbare Bindungen
3
Schwere Atome
19

Experimentelle und physikochemische Eigenschaften

Collision Cross Section146.4 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

Physikochemische Eigenschaften

Schmelzpunkt
173 · 173,5-174°C
Brechungsindex
81 ° · 81 ° (C=2, H2O)
storage temp.
2 · 2-8°C
Löslichkeit
2 O: · H2O: 0.1 g/mL, clear, very faintly yellow
Aggregatzustand
powder
Farbe
white

Sicherheit und Regulatorisches

GHS-Klassifizierung

GHS Classification · 4 Einträge

Danger

H300 (99.1%): Fatal if swallowed [Danger Acute toxicity, oral]

P260, P264, P270, P271, P284, P301+P316, P304+P340, P316, P320, P321, P330, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 113 reports by companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Gefahrenhinweise

Regulatory InformationPilocarpine nitrate: Does not have an individual approval but may be used under an appropriate group standard
Other Safety InformationIMAP assessments - 2(3H)-Furanone, 3-ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-, (3S-cis)-, mononitrate: Environment tier I assessment
Hazard Classes and CategoriesAcute Tox. 2 (99.1%)

Sicherheitsdaten

F
3-10
wgk
3
tsca
TSCA listed
ridadr
3087
hs_code
2939800000
RTECS-Nr.
TK1455000

Chemie und Industrie

Pharmakologische Informationen

MeSH Pharmacological Classification · 2 Einträge

Agents causing contraction of the pupil of the eye. Some sources use the term miotics only for the parasympathomimetics but any drug used to induce miosis is included here.

Drugs that bind to and activate muscarinic cholinergic receptors (RECEPTORS, MUSCARINIC). Muscarinic agonists are most commonly used when it is desirable to increase smooth muscle tone, especially in the GI tract, urinary bladder and the eye. They may also be used to reduce heart rate.

Verwendung und Herstellung

General Manufacturing Information2(3H)-Furanone, 3-ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-, (3S,4R)-, nitrate (1:1): INACTIVE
Anwendungen · 1 Eintrag

VerwendenPilocarpine nitrate salt has been used to measure bronchoconstriction and M2 and M3 muscarinic receptor function in vivo. It has also been used to induce electrographic and behavioral seizures and to study the different patterns of neuronal activation and neurodegeneration in Proechimys rats and Wistar rats.

Vor- und nachgelagerte Produkte

Vorgelagerte Rohstoffe

Anbieter50 Anbieter

北京华美互利生物化工010-56205725 · [email protected]
成都超九八生物科技有限公司13348960310 13348960310 · [email protected]
成都健腾生物技术有限公司028-85159085 · [email protected]
Dayang Chem (Hangzhou) Co.,Ltd.+86-0571-88938639 17705817739 · [email protected]
LGM Pharma1-(800)-881-8210 · [email protected]

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