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Flomoxef
FMOX · Flumarin · FLOMOXEF · FLOMOEXF · Flomoxef Acid · Flomoxef Monomer · Flomoxef USP/EP/BP · Flomoxef Acid(Sodium)
Identifikatoren & physikalische Daten
| CAS No. | 99665-00-6 |
|---|---|
| Summenformel | C15H18F2N6O7S2 |
| Durchschnittliche Molmasse | 496,5 g/mol |
| Monoisotopische Masse | 496,06464536 g/mol |
| SMILES | CO[C@@]1(NC(=O)CSC(F)F)C(=O)N2C(C(=O)O)=C(CSc3nnnn3CCO)CO[C@@H]21 |
| InChIKey | UHRBTBZOWWGKMK-DOMZBBRYSA-N |
| PubChem CID | 65864 |
| ChEMBL | CHEMBL15413 |
| ChEBI | CHEBI:135813 |
| DTXSID | DTXSID5048845 |
Chemische & physikalische Eigenschaften
| XLogP | -1,3 |
|---|---|
| Polarare Oberfläche (TPSA) | 220 |
| H-Brücken-Donoren | 3 |
| H-Brücken-Akzeptoren | 14 |
| Frei drehbare Bindungen | 11 |
| Schwere Atome | 32 |
| Formalladung | 0 |
| Komplexität | 793 |
| Arzneimittel | Pharmaceuticals -> Anti infectives for systemic use -> Antibacterials for systemic usePharmaceuticals -> Listed in ZINC15Pharmaceuticals -> Antibiotics |
| Schmelzpunkt | 82.5-87.5° |
| Dichte | 1.85±0.1 g/cm3(Predicted) |
| Lagerbedingungen | Store at -20°C |
| Löslichkeit | soluble in DMSO, Methanol |
| Aggregatzustand | Solid |
| pKa (Säurekonstante) | 3.26±0.40(Predicted) |
| Farbe | Off-White |
| InChIKey | UHRBTBZOWWGKMK-DOMZBBRYSA-N |
| SMILES | N12[C@@]([H])([C@@](NC(CSC(F)F)=O)(OC)C1=O)OCC(CSC1N(CCO)N=NN=1)=C2C(O)=O |
| CAS Datenbank | 99665-00-6(CAS DataBase Reference) |
Sicherheit & Vorschriften
| Drug Induced Liver Injury | Drug-Induced Liver Injury Severity and Toxicity (DILIst)FlomoxefDILI PositiveDOI:10.1016/j.drudis.2019.09.022 |
|---|
Anwendungen & Verwendung
Beschreibung
Flomoxef sodium is a P-lactamase resistant oxacephalosporin. Its spectrum of activity is similar to that of cefazolin and moxalactam, but with better efficacy against Staphylococcus aureus and Bacteroides fragilis. Flomoxef is reported effective in the treatment of post-operative, urinary tract and abdominal cavity infections.
Verwenden
Flomoxef is an oxacephem derived beta-lactam antibiotic that is particularly effective against gram-positive bacteria.