Diphenylpyralinhydrochlorid
DIPHENYLPYRALINE HCL · 4-Benzhydryloxy-1-methylpiperidine~Diphenylpyraline hydrochloride · Lergobine · Hy-stamin · LABOTEST-BB LT00159897 · Diphenylpyraline hydrochlorid · DIPHENYLPYRALINE HYDROCHLORIDE · 4-diphenylmethoxy-1-methylpiperidine
Identifikatoren & physikalische Daten
| CAS No. | 132-18-3 |
|---|---|
| Summenformel | C19H24ClNO |
| Durchschnittliche Molmasse | 317,9 g/mol |
| Monoisotopische Masse | 317,1546421 g/mol |
| SMILES | CN1CCC(OC(c2ccccc2)c2ccccc2)CC1.Cl |
| InChIKey | LPRLDRXGWKXRMQ-UHFFFAOYSA-N |
| PubChem CID | 66063 |
| ChEMBL | CHEMBL1564 |
| EC No. | 205-049-3 |
| DTXSID | DTXSID7047772 |
| Lokaler Name | Diphenylpyralinhydrochlorid |
Chemische & physikalische Eigenschaften
| Polarare Oberfläche (TPSA) | 12,5 |
|---|---|
| H-Brücken-Donoren | 1 |
| H-Brücken-Akzeptoren | 2 |
| Frei drehbare Bindungen | 4 |
| Schwere Atome | 22 |
| Formalladung | 0 |
| Komplexität | 268 |
| Löslichkeit | >47.7 [ug/mL] (The mean of the results at pH 7.4)Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly), Water (Slightly) |
| Human Drugs | FDA approved drugs -> Active ingredient |
| Collision Cross Section | 173.8 Ų [M+H]+ [CCS Type: TWMethod: calibrated with polyalanine and drug standards] |
| Schmelzpunkt | 203-205 °C(lit.) |
| Lagerbedingungen | under inert gas (nitrogen or Argon) at 2-8°C |
| Aggregatzustand | Solid |
| Farbe | White to Off-White |
| Merck | 13,3363 |
| Stabilität | Hygroscopic |
| InChI | InChI=1S/C19H23NO.ClH/c1-20-14-12-18(13-15-20)21-19(16-8-4-2-5-9-16)17-10-6-3-7-11-17/h2-11,18-19H,12-15H2,1H3 |
| InChIKey | LPRLDRXGWKXRMQ-UHFFFAOYSA-N |
| SMILES | C(OC1CCN(C)CC1)(C1=CC=CC=C1)C1=CC=CC=C1.Cl |
| EPA chemische Informationen | Diphenylpyraline hydrochloride (132-18-3) |
Sicherheit & Vorschriften
| GHS-Einstufung | WarningH302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]P264, P270, P301+P317, P330, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 41 reports by companies from 2 notifications to the ECHA C&L Inventory. |
|---|---|
| Regulatorische Informationen | Piperidine, 4-(diphenylmethoxy)-1-methyl-, hydrochloride: Does not have an individual approval but may be used under an appropriate group standard |
| Weitere Sicherheitsinformationen | IMAP assessments - Piperidine, 4-(diphenylmethoxy)-1-methyl-, hydrochloride: Environment tier I assessment |
| Hazard Classes and Categories | Acute Tox. 4 (100%) |
| Wassergefährdungsklasse (WGK) | 3 |
| TSCA-Inventar-Status | TSCA listed |
| UN-Transportnummer | 3249 |
| RTECS-Nr. | TM7823600 |
| R-Sätze (R) | 20/21/22-36/37/38-22 |
| Toxizität | mouse,LD50,intramuscular,64300ug/kg (64.3mg/kg),Drugs in Japan Vol. 6, Pg. 333, 1982. |
| Gefahrensymbole | Xn |
| Sicherheitshinweise (S) | 26-36 |
| Gefahrenklasse | 6.1(b) |
| Verpackungsgruppe | III |
Anwendungen & Verwendung
Beschreibung
Diphenylpyraline is an antihistamine drug with anticholinergic and sedative action. It is intended for symptomatic treatment of seasonal allergies and allergic reactions as well as an adjuvant drug in anaphylactic reaction therapy. Synonyms of this drug are arbid, timpil, histryl, hispril, and others.
Verwenden
Diphenylpyraline Hydrochloride is a salt of Diphenylpyraline (D492110), an H1 receptor antagonist (an antihistamine) and is commonly prescribed to treat allergic and vasomotor rhinitis. There is also some research being conducted on diphenylpyraline derivatives to determine their antimycobacterial and antifungal activity.