Triflupromazinhydrochlorid
Neoprin · Flumazin · Fluorofen · triflupromazineHCl · LABOTEST-BB LT00772332 · TRIFLUPROMAZINE HCL IP/USP · Fluopromazine hydrochloride · TRIFLUPROMAZINE HYDROCHLORIDE
Identifikatoren & physikalische Daten
| CAS No. | 1098-60-8 |
|---|---|
| Summenformel | C18H20ClF3N2S |
| Durchschnittliche Molmasse | 388,9 g/mol |
| Monoisotopische Masse | 388,098782 g/mol |
| SMILES | CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21.Cl |
| InChIKey | FTNWXGFYRHWUKG-UHFFFAOYSA-N |
| PubChem CID | 66069 |
| ChEMBL | CHEMBL1201102 |
| EC No. | 214-149-6 |
| DTXSID | DTXSID8045804 |
| Lokaler Name | Triflupromazinhydrochlorid |
Chemische & physikalische Eigenschaften
| Polarare Oberfläche (TPSA) | 31,8 |
|---|---|
| H-Brücken-Donoren | 1 |
| H-Brücken-Akzeptoren | 6 |
| Frei drehbare Bindungen | 4 |
| Schwere Atome | 25 |
| Formalladung | 0 |
| Komplexität | 416 |
| Human Drugs | FDA approved drugs -> Active ingredient |
| Animal Drugs | FDA approved animal drugs -> Active ingredient |
| Collision Cross Section | 175.6 Ų [M+H]+ [CCS Type: TWMethod: calibrated with polyalanine and drug standards] |
| Schmelzpunkt | 174.0 to 179.0 °C |
| Lagerbedingungen | Keep in dark place,Inert atmosphere,Room temperature |
| Löslichkeit | Soluble in waterDMF: 5mg/mLDMSO: 3mg/mLEthanol: 5mg/mLEthanol:PBS (pH 7.2) (1:10): 0.09mg/mL |
| Farbe | White to Light yellow |
| Merck | 14,9685 |
| BRN | 3801519 |
| Stabilität | Hygroscopic |
| Hauptanwendungen | pharmaceutical (small molecule) |
| InChI | 1S/C18H19F3N2S.ClH/c1-22(2)10-5-11-23-14-6-3-4-7-16(14)24-17-9-8-13(12-15(17)23)18(19,20)21/h3-4,6-9,12H,5,10-11H2,1-2H3 |
| InChIKey | FTNWXGFYRHWUKG-UHFFFAOYSA-N |
| SMILES | Cl.CN(C)CCCN1c2ccccc2Sc3ccc(cc13)C(F)(F)F |
| CAS Datenbank | 1098-60-8 |
Sicherheit & Vorschriften
| GHS-Einstufung | DangerH301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]P261, P264, P270, P271, P280, P301+P316, P302+P352, P304+P340, P317, P321, P330, P362+P364, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 39 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| Regulatorische Informationen | 10H-Phenothiazine-10-propanamine, N,N-dimethyl-2-(trifluoromethyl)-, monohydrochloride: Does not have an individual approval but may be used under an appropriate group standard |
| Weitere Sicherheitsinformationen | IMAP assessments - 10H-Phenothiazine-10-propanamine, N,N-dimethyl-2-(trifluoromethyl)-, monohydrochloride: Human health tier I assessment |
| Hazard Classes and Categories | Acute Tox. 3 (100%) |
| Wassergefährdungsklasse (WGK) | 3 |
| UN-Transportnummer | UN 2811 6.1/PG 3 |
| Zollcode | 2934302300 |
| RTECS-Nr. | SO8925000 |
| R-Sätze (R) | 20/21/22 |
| Gefahrensymbole | Xn |
| Sicherheitshinweise (S) | 36 |
| Gefahrenklasse | 6.1Acute Tox. 3 OralAcute Tox. 4 DermalAcute Tox. 4 Inhalation |
| Verpackungsgruppe | III |
| Lagerklasse | 6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects |
Anwendungen & Verwendung
Beschreibung
Triflupromazine is a phenothiazine with diverse biological activities. It binds to muscarinic receptors in isolated rat corpus striatum (IC50 = 100 μM in a radioligand binding assay). Triflupromazine inhibits serotonin (5-HT) uptake by isolated rat brainstem synaptosomes (IC50 = 0.8 μM). It inhibits T. cruzi infection in mouse peritoneal macrophages when used at a concentration of 12.5 μM. Triflupromazine is active against S. aureus, shigellae, and vibrios (MICs = 2-100 μg/ml) in vitro and is protective against S. typhimurium infection in mice when administered at a dose of 30 μg per animal. Formulations containing triflupromazine were previously used as antipsychotics.
Verwenden
analgesic, antiinflammatory, antipyretic, COX-II inhibitor