Identifikatoren & physikalische Daten
| CAS No. | 51-57-0 |
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| Summenformel | C10H16ClN |
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| Durchschnittliche Molmasse | 185,69 g/mol |
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| Monoisotopische Masse | 185,09712719 g/mol |
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| SMILES | CN[C@@H](C)Cc1ccccc1.Cl |
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| InChIKey | TWXDDNPPQUTEOV-FVGYRXGTSA-N |
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| PubChem CID | 66124 |
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| ChEMBL | CHEMBL1200952 |
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| ChEBI | CHEBI:35340 |
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| EC No. | 200-106-9 |
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| DTXSID | DTXSID8048864 |
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Chemische & physikalische Eigenschaften
| Polarare Oberfläche (TPSA) | 12 |
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| H-Brücken-Donoren | 2 |
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| H-Brücken-Akzeptoren | 1 |
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| Frei drehbare Bindungen | 3 |
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| Schwere Atome | 12 |
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| Formalladung | 0 |
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| Komplexität | 95 |
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| Human Drugs | FDA approved drugs -> Active ingredient |
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Sicherheit & Vorschriften
| GHS-Einstufung | DangerH301 (93%): Toxic if swallowed [Danger Acute toxicity, oral]P264, P270, P301+P316, P321, P330, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 43 reports by companies from 5 notifications to the ECHA C&L Inventory. |
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| Regulatorische Informationen | Benzeneethanamine, N,.alpha.-dimethyl-, hydrochloride, (.alpha.S)-: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right. |
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| Hazard Classes and Categories | Acute Tox. 3 (93%) |
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| Treatment | Management of acute methamphetamine intoxication is largely symptomatic and includes gastric evacuation, administration of activated charcoal, and sedation. Experience with hemodialysis or peritoneal dialysis is inadequate to permit recommendations in this regard. Acidification of urine increases methamphetamine excretion, but is believed to increase risk of acute renal failure if myoglobinuria is present. Intravenous phentolamine has been suggested for possible acute, severe hypertension, if this complicates methamphetamine overdosage. Usually a gradual drop in blood pressure will result when sufficient sedation has been achieved. Chlorpromazine has been reported to be useful in decreasing CNS stimulation and sympathomimetic effects. (L1712) |
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| Gesundheitliche Auswirkungen | Using large amounts of these drugs can result in a condition known as amphetamine psychosis -- which can result in auditory, visual and tactile hallucinations, intense paranoia, irrational thoughts and beliefs, delusions, and mental confusion. |
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| Expositionspfade | Methamphetamine is rapidly absorbed from the gastrointestinal tract with peak methamphetamine concentrations occurring in 3.13 to 6.3 hours post ingestion. Methamphetamine is also well absorbed following inhalation and following intranasal administration. It is distributed to most parts of the body. Because methamphetamine has a high lipophilicity it is distributed across the blood brain barrier and crosses the placenta. |
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| Toxizitätsübersicht | Methamphetamine enters the brain and triggers a cascading release of norepinephrine, dopamine and serotonin. To a lesser extent methamphetamine acts as a dopaminergic and adrenergic reuptake inhibitor and in high concentrations as a monamine oxidase inhibitor (MAOI). The mechanism of action involved in producing the beneficial behavioral changes seen in hyperkinetic children receiving methamphetamine is unknown. |
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