Bis(4-chlorphenyl)sulfon

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SMALL SPILLS AND LEAKAGE: If a spill of this chemical occurs, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with acetone and transfer the dampened material to a suitable container. Use absorbent paper dampened with acetone to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with acetone followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

RECOMMENDED RESPIRATOR: Where the neat test chemical is stored, weighed and diluted, wear an approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 7,600(SRC), determined from a structure estimation method(2), indicates that 4,4'-dichlorophenyl sulfone is expected to be immobile in soil(SRC). Volatilization of 4,4'-dichlorophenyl sulfone from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 1.4X10-7 atm-cu m/mole(SRC), using a fragment constant estimation method(3). 4,4'-Dichlorophenyl sulfone is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 8.1X10-7 mm Hg(SRC), determined from a fragment constant method(4). Biodegradation data were not available(SRC, 2005).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 7,600(SRC), determined from a structure estimation method(2), indicates that 4,4'-dichlorophenyl sulfone is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 1.4X10-7 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). According to a classification scheme(5), an estimated BCF of 200(SRC), from an estimated log Kow of 3.9(6) and a regression-derived equation(7), suggests the potential for bioconcentration in aquatic organisms is high(SRC). Biodegradation data were not available(SRC, 2005).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 4,4'-dichlorophenyl sulfone, which has an estimated vapor pressure of 8.1X10-7 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase 4,4'-dichlorophenyl sulfone is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 27 days(SRC), calculated from its rate constant of 5.9X10-13 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Particulate-phase 4,4'-dichlorophenyl sulfone may be removed from the air by wet and dry deposition(SRC). 4,4'-Dichlorodiphenyl sulfone does not absorb at wavelengths >290(4) and therefore, is not expected to by susceptible to direct photolysis.

The following link will take the user to the National Toxicology Program (NTP) Test Agent Search Results page, which tabulates all of the "Standard Toxicology & Carcinogenesis Studies", "Developmental Studies", and "Genetic Toxicity Studies" performed with this chemical. Clicking on the "Testing Status" link will take the user to the status (i.e., in review, in progress, in preparation, on test, completed, etc.) and results of all the studies that the NTP has done on this chemical. [http://ntp-apps.niehs.nih.gov/ntp_tox/index.cfm?fuseaction=ntpsearch.searchresults&searchterm=80-07-9]

Using a structure estimation method based on molecular connectivity indices(1), the Koc for 4,4'-dichlorophenyl sulfone can be estimated to be 7,600(SRC). According to a classification scheme(2), this estimated Koc value suggests that 4,4'-dichlorophenyl sulfone is expected to be immobile in soil.

p,p'-Dichlorodiphenyl Sulfone

TR-501: Toxicology and Carcinogenesis Studies of p,p'-Dichlorodiphenyl Sulfone (CASRN 80-07-9) in F344/N Rats and B6C3F1 Mice (Feed Studies) (2001 )

05/18/00

No Evidence

No Evidence

No Evidence

An estimated BCF of 200 was calculated for 4,4'-dichlorophenyl sulfone(SRC), using an estimated log Kow of 3.9(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is high(SRC).

The Henry's Law constant for 4,4'-dichlorophenyl sulfone is estimated as 1.4X10-7 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This Henry's Law constant indicates that 4,4'-dichlorophenyl sulfone is expected to be essentially nonvolatile from water surfaces(2). 4,4'-dichlorophenyl sulfone is not expected to volatilize from dry soil surfaces(SRC) based upon a an estimated vapor pressure of 8.1X10-7 mm Hg(SRC), determined from a fragment constant method(3).

/LABORATORY ANIMALS: Subchronic or Prechronic Exposure/ In 6-month rat oral study, 2.0 mg/kg bw dose affected liver, kidney, and CNS functions. The NOAEL was found to be 0.02 mg/kg bw in this study.

/LABORATORY ANIMALS: Developmental or Reproductive Toxicity/ Rats were given ... bis(p-chlorodiphenyl)sulfone/kg bw for month. The treatment caused an increase in the pre- and postimplantation embryonal mortality. No adverse effect was observed at 0.5 mg/kg bw.

The rate constant for the vapor-phase reaction of 4,4'-dichlorophenyl sulfone with photochemically-produced hydroxyl radicals has been estimated as 5.9X10-13 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 27 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). 4,4'-dichlorophenyl sulfone is not expected to undergo hydrolysis in the environment due to the lack of hydrolyzable functional groups(2). 4,4'-Dichlorodiphenyl sulfone does not absorb at wavelengths >290(3) and therefore, is not expected to by susceptible to direct photolysis.

4,4'-Dichlorophenyl sulfone's production and use as an intermediate in pharmaceutical synthesis and in high temperature plastics may result in its release to the environment through various waste streams. If released to air, an estimated vapor pressure of 8.1X10-7 mm Hg at 25 °C indicates 4,4'-dichlorophenyl sulfone will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase 4,4'-dichlorophenyl sulfone will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 27 days. Particulate-phase 4,4'-dichlorophenyl sulfone will be removed from the atmosphere by wet and dry deposition. 4,4'-Dichlorodiphenyl sulfone does not absorb at wavelengths >290 and therefore, is not expected to by susceptible to direct photolysis. If released to soil, 4,4'-dichlorophenyl sulfone is expected to have no mobility based upon an estimated Koc of 7,600. Volatilization from moist soil surfaces is not expected to be an important fate process based upon an estimated Henry's Law constant of 1.4X10-7 atm-cu m/mole. 4,4'-Dichlorophenyl sulfone is not expected to volatilize from dry soil surfaces based upon its vapor pressure. If released into water, 4,4'-dichlorophenyl sulfone is expected to adsorb to suspended solids and sediment based upon the estimated Koc. Volatilization from water surfaces is not expected to be an important fate process based upon this compound's estimated Henry's Law constant. An estimated BCF of 200 suggests the potential for bioconcentration in aquatic organisms is high. Hydrolysis is not expected to be an important environmental fate process since this compound lacks functional groups that hydrolyze under environmental conditions. Occupational exposure to 4,4'-dichlorophenyl sulfone may occur through inhalation and dermal contact with this compound at workplaces where 4,4'-dichlorophenyl sulfone is produced or used. (SRC)

Section 8(a) of TSCA requires manufacturers of this chemical substance to report preliminary assessment information concerned with production, exposure, and use to EPA as cited in the preamble in 51 FR 41329.

Pursuant to section 8(d) of TSCA, EPA promulgated a model Health and Safety Data Reporting Rule. The section 8(d) model rule requires manufacturers, importers, and processors of listed chemical substances and mixtures to submit to EPA copies and lists of unpublished health and safety studies. Sulfone bis-(4-chlorobenzene) is included on this list.

Used in high temperature plastics and as intermediate for Dapsone (an anti-leprotic drug and epoxy hardener); [HSDB]

Used as a component of high temperature plastics.

As intermediate for Dapsone (antileprotic drug and epoxy hardener)

Hinduston Monomers; Product list. Available at http://www.hindustanmonomers.com/products/ind_pro.htm as of Feb 14, 2005.

Plastics Material and Resin Manufacturing

Benzene, 1,1'-sulfonylbis[4-chloro-: ACTIVE

Insecticidal property of bis(p-chlorophenyl)sulfone: Unsymmetrical Deriv was developed for Insecticidal purposes by Stauffer chem.