Nitarsone｜Huagongshe

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HCID 66826Erstellt: 27. Oktober 2026

Nitarson

4-NBA · ras-26 · NSC-5085 · nitarson · NITARSONE · ep-a-stat · histostat · hep-a-stat

https://huagongshe.com/de/chemical/66826

Molekülstruktur von Nitarson

Identifikatoren & physikalische Daten

CAS No.	98-72-6
Summenformel	C6H6AsNO5
Durchschnittliche Molmasse	247,04 g/mol
Monoisotopische Masse	246,946192 g/mol
SMILES	O=[N+]([O-])c1ccc([As](=O)(O)O)cc1
InChIKey	FUUFQLXAIUOWML-UHFFFAOYSA-N
PubChem CID	66826
ChEMBL	CHEMBL1721359
ChEBI	CHEBI:62629
EC No.	202-695-8
DTXSID	DTXSID9045007
Lokaler Name	Nitarson

Chemische & physikalische Eigenschaften

Polarare Oberfläche (TPSA)	103
H-Brücken-Donoren	2
H-Brücken-Akzeptoren	5
Frei drehbare Bindungen	1
Schwere Atome	13
Formalladung	0
Komplexität	236
Schmelzpunkt	298 - 300 °C300°C(lit.)
Physical Description	Solid
Collision Cross Section	138.9 Å² [M-H]- [CCS Type: DTBuffer gas: N2Ionization: ESI-Dataset: TOXCASTSource Identifier: DTXSID9045007]
Siedepunkt	540.9±52.0 °C(Predicted)
Löslichkeit	DMSO (Slightly), Methanol (Slightly)
Aggregatzustand	liquid
pKa (Säurekonstante)	pK1:2.90pK2:7.80 (25°C)
Farbe	Pale-yellow leaflets from H2O
Merck	14,6566
CAS Datenbank	98-72-6(CAS DataBase Reference)
EPA chemische Informationen	Arsonic acid, (4-nitrophenyl)- (98-72-6)

Sicherheit & Vorschriften

GHS-Einstufung	DangerH301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]P261, P264, P270, P271, P273, P301+P316, P304+P340, P316, P321, P330, P391, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 41 reports by companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Regulatorische Informationen	Regulation (EC) No 1831/2003 (amended)Restricted substance: Nitarsone
Weitere Sicherheitsinformationen	IMAP assessments - Arsonic acid, (4-nitrophenyl)-: Human health tier I assessment
Hazard Classes and Categories	Acute Tox. 3 (100%)
Minimum Risk Level	Acute Oral: 0.005 mg/kg/day (L134) Chronic Oral: 0.0003 mg/kg/day (L134) Chronic Inhalation: 0.01 mg/m3 (L134)
Treatment	Aggressive decontamination with gastric lavage is recommended if the patient has consumed a potentially life-threatening dose and if the patient is not vomiting (T36).
Gesundheitliche Auswirkungen	Hypovolemia from capillary leakage (third-spacing of fluids) is a common, serious, early effect. Muscle cramps, facial edema, bronchitis, dyspnea, chest pain, dehydration, intense thirst, and fluid-electrolyte disturbances are also common following significant exposures. A garlic-like odor of the breath and feces may also occur. After absorption, arsenic may cause multi-organ failure by inhibiting sulfhydryl-containing enzymes. Encephalopathy, with headache, lethargy, mental confusion, hallucinations, emotional lability, memory loss and delirium may occurseizures, stupor, convulsions, coma, and death may follow within 24 hours of a severe acute exposure. Dysrhythmias (particularly QTc prolongation and torsade de pointes), cardiomyopathy, ARDS, hepatitis, rhabdomyolysis, hemolysis, and renal failure may develop over several days. The sequence of chronic poisoning involves hyperpigmentation, and eczematoid and allergic dermatitis. muscle fasciculationsgross tremorsataxiaincoordinationand mental confusion. Muscular weakness, limb tenderness and difficulty walking may follow. The final phase consists of peripheral sensory neuropathy of the hands and feet. That may be associated with a motor neuropathy as well (T36).

Anwendungen & Verwendung

Verwenden

Nitarsone is used as an antihistomonad.

Toxizitätsübersicht

Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by competing with phosphate it uncouples oxidative phosphorylation, thus inhibiting energy-linked reduction of NAD+, mitochondrial respiration, and ATP synthesis. Hydrogen peroxide production is also increased, which might form reactive oxygen species and oxidative stress. Arsenic's carcinogenicity is influenced by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. The binding of other arsenic protein targets may also cause altered DNA repair enzyme activity, altered DNA methylation patterns and cell proliferation. (T1, A17)

Signs and Symptoms

Initial signs and symptoms of arsenic ingestion include burning lips, throat constriction and dysphagia, followed by excruciating abdominal pain, hemorrhagic gastritis, gastroenteritis, severe nausea, projectile voting, profuse "rice water-like" diarrhea, with hypovolemia that may result in hypotension and an irregular pulse. The sequence of chronic poisoning involves weakness, anorexia, hepatomegaly, jaundice, and gastrointestinal complaints, followed by conjunctivitis, irritation of the throat and respiratory tract. ther effects of chronic exposure include conjunctivitis with irritation and lacrimationhair, skin and nail changeshyperkeratosis of feet and handsand melanosis, with pigment spots in corneal and conjunctival epithelium. Peripheral nervous system symptoms may include numbness, burning, and tingling of the hands and feetparesthesiastenderness (T36).