GW-610
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Grundinformationen
- CAS
872726-44-8- Standard-SMILES
COc1ccc(-c2nc3cc(F)ccc3s2)cc1OC- InChIKey
ZRLSVQBGBBYEAZ-UHFFFAOYSA-N- Summenformel
- C15H12FNO2S
- Durchschnittliche Molmasse
- 289,331 g/mol
- Monoisotopische Masse
- 289,05727784
Namen und Bezeichner
- Bevorzugter Name
- GW-610
- IUPAC
- 2-(3,4-Dimethoxyphenyl)-5-fluoro-1,3-benzothiazole
- Englischer Name
- GW 610
- Summenformel
- C15H12FNO2S
- Molmasse
- 289.3246832
Namen und Synonyme
NSC 721648GW 610NSC 721648 PMX 610GW 610, 10 mM in DMSOPMX 610 NSC 721648 W 610NSC 721648 - CAS 872726-44-8 - Calbiochem2-(3,4-Dimethoxyphenyl)-5-fluorobenzo[d]thiazoleBenzothiazole, 2-(3,4-dimethoxyphenyl)-5-fluoro-GW 610,colon,Inhibitor,GW610,NSC721648,inhibit,breast,antitumor,NSC 721648,lung,GW-610,NSC-721648
Datenbank-Bezeichner
- CAS
872726-44-8- PubChem CID
- 6712941
- DTXSID
DTXSID60236247- ChEMBL
CHEMBL373251- UNII
- X3XWA9LQ3Q
- Nikkaji
- J2.725.682A
Eigenschaften
Physikochemische Eigenschaften
- Schmelzpunkt
- 110 °C · 110 °C
- Siedepunkt
- 422.8 · 422.8±55.0 °C(Predicted)
- Dichte
- 1.293 · 1.293±0.06 g/cm3(Predicted)
- storage temp.
- 2 C · +2C to +8C
- Löslichkeit
- 10 · DMF:10.0(Max Conc. mg/mL);34.56(Max Conc. mM)DMF:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.86(Max Conc. mM)DMSO:9.5(Max Conc. mg/mL);32.84(Max Conc. mM)
- Aggregatzustand
- White crystalline solid
- pka
- 0.73 · 0.73±0.10(Predicted)
- Farbe
- Light yellow to brown
Chemie und Industrie
Anwendungen
BeschreibungGW 610 is an antitumor benzothiazole that shows growth-inhibitory activity against several cancer cell lines. In MCF-7 and MDA 468 human cancer cell lines, potent antiproliferative activity (growth inhibition (GI50) (4-aminophenyl)benzothiazoles, GW 610 is not reliant on induction of cytochrome P 1A1 (CYP1A1) expression for antitumor activity.
VerwendenGW 610 is a fluorinated 2-arylbenzothiazole and potential antitumor drug, which shows potent and selective inhibitory activity against breast, lung, and colon cancer cell lines. Studies suggest that the species-specific partial agonism of the aryl hydrocarbon receptor shown by GW 610 plays an important role in its anti-proliferative activity.
Anbieter15 Anbieter
上海毕得医药科技股份有限公司400-1647117 13681763483 · [email protected]
江苏艾康生物医药研发有限公司025-5885952 15955137747 · [email protected]
MedBio脉铂医药021-69568360 18916172912 · [email protected]
湖北魏氏化学试剂股份有限公司17771898297 13125137661 · [email protected]
上海陶素生化科技有限公司021-33632979 · [email protected]
天津普西唐生物医药科技有限公司010-60605840 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
上海源叶生物科技有限公司18916372613 · [email protected]
东营四方利通新材料有限公司13589435123 17861826421 · [email protected]
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