Grundinformationen
- Standard-SMILES
Cc1cccc(Cn2nc(C3CC3)c3c(NC(=O)c4cnc5cc(OCCN6CCN(C)CC6)ccn45)cccc32)n1- InChIKey
JUPOTOIJLKDAPF-UHFFFAOYSA-N- Summenformel
- C32H36N8O2
- Durchschnittliche Molmasse
- 564,7 g/mol
Überblick
cFMS Tyrosine Kinase Inhibitor ARRY-382 is a small molecule and orally available inhibitor of colony-stimulating factor-1 receptor (CSF1R; cFMS) with potential antineoplastic activity. cFMS tyrosine kinase inhibitor ARRY-382 binds to and inhibits the activity of cFMS. By preventing colony-stimulating factor-1 (CSF-1)-cFMS signaling, this agent may inhibit tumor cell proliferation in cFMS-overexpressing tumor cells. cFMS, a tyrosine kinase receptor, is overexpressed in certain tumor cell types and plays an essential role in macrophage differentiation and regulation of cell proliferation.
Namen und Bezeichner
- Bevorzugter Name
- Arry-382
- IUPAC
- N-[3-cyclopropyl-1-[(6-methyl-2-pyridinyl)methyl]indazol-4-yl]-7-[2-(4-methylpiperazin-1-yl)ethoxy]imidazo[1,2-a]pyridine-3-carboxamide
Namen und Synonyme
ARRY-382c-Fms-IN-12ARRY382ARRY 382N-[3-cyclopropyl-1-[(6-methylpyridin-2-yl)methyl]indazol-4-yl]-7-[2-(4-methylpiperazin-1-yl)ethoxy]imidazo[1,2-a]pyridine-3-carboxamidePF-07265804PF07265804N-(3-cyclopropyl-1-((6-methylpyridin-2-yl)methyl)indazol-4-yl)-7-(2-(4-methylpiperazin-1-yl)ethoxy)imidazo(1,2-a)pyridine-3-carboxamideRefChem:114168cFMS Tyrosine Kinase Inhibitor ARRY-3821313407-95-2N-(3-cyclopropyl-1-((6-methylpyridin-2-yl)methyl)-1H-indazol-4-yl)-7-(2-(4-methylpiperazin-1-yl)ethoxy)imidazo[1,2-a]pyridine-3-carboxamide
Weitere Namen anzeigen
N-[3-Cyclopropyl-1-[(6-methylpyridin-2-yl)methyl]-1H-indazol-4-yl]-7-[2-(4-methylpiperazin-1-yl)ethoxy]imidazo[1,2-a]pyridine-3-carboxamideGTPL9108orb1304109SCHEMBL2048345CHEMBL3644252SCHEMBL29370287SCHEMBL30772280JUPOTOIJLKDAPF-UHFFFAOYSA-N
Datenbank-Bezeichner
- PubChem CID
- 67259771
- ChEMBL
CHEMBL3644252
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- 3,9
- Polarare Oberfläche (TPSA)
- 92,8 Ų
- H-Brücken-Donoren
- 1
- H-Brücken-Akzeptoren
- 7
- Frei drehbare Bindungen
- 9
- Schwere Atome
- 42
- Formalladung
- 0
- Komplexität
- 913
Zugehörige Reaktionen
1
Verknüpfte Notizen
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