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2-Fluorbiphenyl

2-Fluorobiphenyl

HCID 67579
NotizenReaktionen
GrundinformationenNamen und BezeichnerEigenschaftenSicherheit und RegulatorischesChemie und IndustrieZugehörige ReaktionenNotizen zur Verbindung
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Grundinformationen

CAS
321-60-8
Standard-SMILES
Fc1ccccc1-c1ccccc1
InChIKey
KLECYOQFQXJYBC-UHFFFAOYSA-N
Summenformel
C12H9F
Durchschnittliche Molmasse
172,2 g/mol
Monoisotopische Masse
172,06882845

Namen und Bezeichner

Bevorzugter Name
2-Fluorobiphenyl
IUPAC
1-fluoro-2-phenylbenzene
Lokaler Name
2-Fluorbiphenyl
Englischer Name
2-Fluorobiphenyl
Summenformel
C12H9F
Molmasse
172.2

Namen und Synonyme

2-Fluorobiphenyl321-60-82-Fluoro-1,1'-biphenylo-FluorodiphenylBiphenyl, 2-fluoro-1,1'-Biphenyl, 2-fluoro-ortho-FluorodiphenylCCRIS 1659DTXSID5047744EINECS 206-290-7NSC 10366DTXCID5027728
Weitere Namen anzeigen
Fluorobiphenyl48722-u2-Fluorobiphen2-FLUORODIPHENYL2-fluoro-biphenyo-Fluorobiphenyl
oFluorodiphenylorthoFluorodiphenylBiphenyl, 2fluoroFluorobiphenyl, 22Fluoro1,1'biphenylRefChem:4726211,1'Biphenyl, 2fluoro206-290-7

Datenbank-Bezeichner

CAS
321-60-8
PubChem CID
67579
DTXSID
DTXSID5047744
ChEMBL
CHEMBL122521
UNII
KC8Q87V4QY
EC Number
206-290-7
Nikkaji
J27B

Eigenschaften

Berechnete Struktureigenschaften

XLogP
4
Polarare Oberfläche (TPSA)
0 Ų
H-Brücken-Donoren
0
H-Brücken-Akzeptoren
1
Frei drehbare Bindungen
1
Schwere Atome
13
Formalladung
0
Komplexität
149

Experimentelle und physikochemische Eigenschaften

Density1.2452 at 77 °F (NTP, 1992) - Denser than water; will sink
Boiling Point478 °F at 760 mmHg (NTP, 1992)
Melting Point164.3 °F (NTP, 1992)
Physical Description · 2 Einträge

2-fluorobiphenyl appears as colorless crystals.

Colorless solid; [CAMEO] Off-white crystalline powder; [Alfa Aesar MSDS]

Kovats Retention Index · 3 Einträge

1346;232.03

1346;231.69;233.5

226.44

Physikochemische Eigenschaften

Schmelzpunkt
71 · 71-74 °C (lit.)
Siedepunkt
248 °C · 248 °C (lit.)
Dichte
1 · 1,245 g/cm3
Brechungsindex
1.5678 · 1.5678 (estimate)
Flammpunkt
248 °C · 248°C
storage temp.

Sicherheit und Regulatorisches

Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.

GHS-Klassifizierung

GHS Classification · 6 Einträge

This chemical does not meet GHS hazard criteria for 28.6% (2 of 7) of reports.

Danger

H302 (14.3%): Harmful if swallowed [Warning Acute toxicity, oral];H315 (71.4%): Causes skin irritation [Warning Skin corrosion/irritation];H318 (14.3%): Causes serious eye damage [Danger Serious eye damage/eye irritation];H319 (57.1%): Causes serious eye irritation [Warning Serious eye damage/eye irritation];H335 (71.4%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation];H400 (28.6%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard];H410 (14.3%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]

P261, P264, P264+P265, P270, P271, P273, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 7 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.;Reported as not meeting GHS hazard criteria per 2 of 7 reports by companies.;There are 4 notifications provided by 5 of 7 reports by companies with hazard statement code(s).;Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

Gefahrenhinweise

DOT LabelClass 9
Fire Hazards · 1 Eintrag

Excerpt from ERG Guide 171 [Substances (Low to Moderate Hazard)]:;Some may burn but none ignite readily. Containers may explode when heated. Some may be transported hot. For UN3508, Capacitor, asymmetric, be aware of possible short circuiting as this product is transported in a charged state. Polymeric beads, expandable (UN2211) may evolve flammable vapours. (ERG, 2024)

Chemie und Industrie

Verwendung und Herstellung

General Manufacturing Information1,1'-Biphenyl, 2-fluoro-: ACTIVE
Anwendungen · 1 Eintrag

Verwenden2-Fluorobiphenyl is used as pharmaceuticals, veterinary drugs and organic synthesis intermediates. 2-Fluorobiphenyl was used as an internal standard for analysis of environmental pollutants in sediments using pressurized liquid extraction and gas chromatography-mass spectrometry, as a sole carbon & energy source for P. pseudoalcaligenes.

Vor- und nachgelagerte Produkte

Vorgelagerte Rohstoffe

Methanesulfonic acid, 1,1,1-trifluoro-, [1,1'-biphenyl]-2-yl esterBenzenediazonium, 2-fluoro-, tetrafluoroborate(1-)Phenyltriallylsilane4-Brom-2-fluor-1,1'-biphenylNatriumtetraphenylborat

Nachgelagerte Produkte

Flurbiprofen1-(2'-Fluor[1,1'-biphenyl]-4-yl)ethan-1-on

Anbieter100 Anbieter

国药集团化学试剂有限公司

Zugehörige Reaktionen

23
Reaktionsaufzeichnung erstellen
Reaktionsgleichung von HRID 98603
HRID 98603als EduktTraining data from https://doi.org/10.1039/C8SC04228D (2/10)
Reaktionsgleichung von HRID 167660
HRID 167660als EduktTraining data from https://doi.org/10.1039/C8SC04228D (9/10)
Reaktionsgleichung von HRID 173451
HRID 173451als EduktTraining data from https://doi.org/10.1039/C8SC04228D (9/10)
Reaktionsgleichung von HRID 173636
HRID 173636als EduktTraining data from https://doi.org/10.1039/C8SC04228D (9/10)
Reaktionsgleichung von HRID 264774
HRID 264774als Eduktuspto-grants-1997_07
Reaktionsgleichung von HRID 381831
HRID 381831als Eduktuspto-grants-2001_10
Reaktionsgleichung von HRID 808794
HRID 808794als EduktTest data from https://doi.org/10.1039/C8SC04228D
Reaktionsgleichung von HRID 838238
HRID 838238als EduktTest data from https://doi.org/10.1039/C8SC04228D
Seite 1 von 3

Notizen zur Verbindung

Wird geladen…

Auf dieser SeiteGrundinformationenNamen und BezeichnerEigenschaftenSicherheit und RegulatorischesChemie und IndustrieZugehörige ReaktionenNotizen zur Verbindung
Sealed in dry,Room Temperature
Löslichkeit
Chloroform (Slightly), Methanol (Slightly)
Aggregatzustand
powder to crystal
Farbe
White to Light yellow
Wasserlöslichkeit
Soluble in alcohol, ether. Insoluble in water.
BRN
2043175 · 2043175
Stabilität
Stable. Incompatible with strong oxidizing agents. Combustible.
InChI
1S/C12H9F/c13-12-9-5-4-8-11(12)10-6-2-1-3-7-10/h1-9H
InChIKey
KLECYOQFQXJYBC-UHFFFAOYSA-N
SMILES
Fc1ccccc1-c2ccccc2
CAS Datenbank
321 · 321-60-8(CAS DataBase Reference)
NIST chemische Informationen
1 · 1,1'-Biphenyl, 2-fluoro-(321-60-8)
EPA chemische Informationen
2 · 2-Fluorobiphenyl (321-60-8)
Health Hazards · 1 Eintrag

Excerpt from ERG Guide 171 [Substances (Low to Moderate Hazard)]:;Inhalation of material may be harmful. Contact may cause burns to skin and eyes. Inhalation of Asbestos dust may have a damaging effect on the lungs. Fire may produce irritating, corrosive and/or toxic gases. Some liquids produce vapors that may cause dizziness or asphyxiation. Runoff from fire control or dilution water may cause environmental contamination. (ERG, 2024)

Hazards SummaryMay cause irritation; [Alfa Aesar MSDS] See Biphenyl.
Reactive GroupAryl Halides
Reactivity Profile · 1 Eintrag

Simple aromatic halogenated organic compounds, such as 2-FLUOROBIPHENYL, are very unreactive. Halogenated organics generally become less reactive as more of their hydrogen atoms are replaced with halogen atoms. Materials in this group may be incompatible with strong oxidizing and reducing agents. Also, they may be incompatible with many amines, nitrides, azo/diazo compounds, alkali metals, and epoxides.

Air and Water ReactionsInsoluble in water.
Hazard Classes and CategoriesAcute Tox. 4 (14.3%);Skin Irrit. 2 (71.4%);Eye Dam. 1 (14.3%);Eye Irrit. 2 (57.1%);STOT SE 3 (71.4%);Aquatic Acute 1 (28.6%);Aquatic Chronic 1 (14.3%)

Sicherheit und Schutzausrüstung

Fire Fighting · 1 Eintrag

This compound is not very flammable but any fire involving this compound may produce dangerous vapors. You should evacuate the area. All firefighters should wear full-body protective clothing and use self-contained breathing apparatuses. You should extinguish any fires involving this chemical with a dry chemical, carbon dioxide, foam, or halon extinguisher. (NTP, 1992)

First Aid · 1 Eintrag

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.;SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.;INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.;INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

Nonfire Spill Response · 1 Eintrag

SMALL SPILLS AND LEAKAGE: You should dampen the solid spill material with acetone, then transfer the dampened material to a suitable container. Use absorbent paper dampened with acetone to pick up any remaining material. Seal your contaminated clothing and the adsorbent paper in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with acetone followed by washing with a strong soap and water solution. Do not reenter the contaminate area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.;STORAGE PRECAUTIONS: You should protect this material from exposure to light, and store it in a refrigerator. (NTP, 1992)

Isolation and Evacuation · 1 Eintrag

Excerpt from ERG Guide 171 [Substances (Low to Moderate Hazard)]:;IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.;SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.;FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

Personal Protective Equipment (PPE) · 1 Eintrag

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter.;RECOMMENDED GLOVE MATERIALS: Permeation data indicate that Viton gloves may provide protection to contact with this compound. Viton over latex gloves is recommended. However, if this chemical makes direct contact with your gloves, or if a tear, hole or puncture develops, remove them at once. (NTP, 1992)

Toxikologische Informationen

EPA Provisional Peer-Reviewed Toxicity Values · 3 Einträge

2-Fluorobiphenyl

PDF Document

2004

Sicherheitsdaten

wgk
3
tsca
TSCA listed
ridadr
UN 1593 6.1/PG 3
hs_code
29036990
RTECS-Nr.
DV5291000
risk_code
36/37/38-63-43-23/24/25-45-40-50/53-41-37/38-22-52/53
hazard_code
Xi,T,Xn,N
safety_code
22-24/25-36/37/39-36/37-23-53-61-60-39-26
hazard_class
IRRITANT
Speicherklasse
11 - Combustible Solids
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