HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
MK 485
MK 485 · R-(+)-Carbidopa · Carbidopa Impurity 18 · Carbidopa Impurity 12 · (R)-carbidopa impurity control · Carbidopa Impurity 2 Trifluoroacetate · Benzenepropanoic acid, α-hydrazino-3,4-dihydroxy-a-methyl-, (R)- · Hydrocinnamic acid, α-hydrazino-3,4-dihydroxy-α-methyl-, D- (8CI)
Identifikatoren & physikalische Daten
| CAS No. | 28875-92-5 |
|---|---|
| Summenformel | C10H14N2O4 |
| Durchschnittliche Molmasse | 226,23 g/mol |
| SMILES | C[C@](Cc1ccc(O)c(O)c1)(NN)C(=O)O |
| InChIKey | TZFNLOMSOLWIDK-JQHDBZEONA-N |
| PubChem CID | 676113 |
| ChEMBL | CHEMBL1417392 |
Chemische & physikalische Eigenschaften
| Schmelzpunkt | >163°C (dec.) |
|---|---|
| Siedepunkt | 528.7±50.0 °C(Predicted) |
| Dichte | 1.420±0.06 g/cm3(Predicted) |
| Lagerbedingungen | Hygroscopic, Refrigerator, under inert atmosphere |
| Löslichkeit | DMSO (Slightly), Methanol (Slightly, Heated, Sonicated) |
| pKa (Säurekonstante) | 3.40±0.14(Predicted) |
| Aggregatzustand | Solid |
| Farbe | Off-White to Beige |
| Stabilität | Hygroscopic |
| InChI | InChI=1/C10H14N2O4/c1-10(12-11,9(15)16)5-6-2-3-7(13)8(14)4-6/h2-4,12-14H,5,11H2,1H3,(H,15,16)/t10-/s3 |
| InChIKey | TZFNLOMSOLWIDK-JQHDBZEONA-N |
| SMILES | [C@](C)(NN)(C(=O)O)CC1C=CC(O)=C(O)C=1 |&1:0,r| |
Anwendungen & Verwendung
Verwenden
R-(+)-Carbidopa is an inhibitor of DOPA decarboxylase, which plays a significant role in the prevention of the conversion of L-DOPA (D533751) to dopamine (D533780). Studies has also indicated the inhibitory effects of towards L-DOPA in human liver prepns and as well as 5-hydroxytryptophan (H975700).