2,2,2-Trifluoracetamid
Trifluoroacetamide
Grundinformationen
- CAS
354-38-1- Standard-SMILES
NC(=O)C(F)(F)F- InChIKey
NRKYWOKHZRQRJR-UHFFFAOYSA-N- Summenformel
- C2H2F3NO
- Durchschnittliche Molmasse
- 113,04 g/mol
- Monoisotopische Masse
- 113,00884834
Namen und Bezeichner
- Bevorzugter Name
- Trifluoroacetamide
- IUPAC
- 2,2,2-trifluoroacetamide
- Lokaler Name
- 2,2,2-Trifluoracetamid
- Englischer Name
- Trifluoroacetamide
- Summenformel
- C2H2F3NO
- Molmasse
- 113.04
Namen und Synonyme
Trifluoroacetamide2,2,2-Trifluoroacetamide354-38-1Acetamide, 2,2,2-trifluoro-36MU16BYFKNSC-9449DTXSID1059868RefChem:191574DTXCID0039011206-559-9N-trifluoroacetamideC2H2F3NO
Weitere Namen anzeigen
CF3CONH2Triflouroacetamide2-TriflouroacetaMide2,2,4-TrifluoroacetamideThree-Three fluoroacetaMide
MFCD00008008trifluroacetamidetrifluoroacetic acid amidetrifluoro-acetamideNSC 9449BDBM50226184AKOS005207149T0598
Datenbank-Bezeichner
- CAS
354-38-1- PubChem CID
- 67717
- DTXSID
DTXSID1059868- ChEMBL
CHEMBL117012- UNII
- 36MU16BYFK
- EC Number
- 206-559-9
- Nikkaji
- J157.866I
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- 0,1
- Polarare Oberfläche (TPSA)
- 43,1 Ų
- H-Brücken-Donoren
- 1
- H-Brücken-Akzeptoren
- 4
- Frei drehbare Bindungen
- 0
- Schwere Atome
- 7
- Formalladung
- 0
- Komplexität
- 85,4
Experimentelle und physikochemische Eigenschaften
Chemical ClassesNitrogen Compounds -> Other Nitrogen Compounds
PFAS
PFAS -> PFAS identified in REACH Regulation EC No. 1272/2008
PFAS -> Suspected persistent, mobile, toxic (PMT) PFAS or PFAS-like compounds
PFAS
SpringerMaterials PropertiesSchoenflies notation
LogP0.12
Vapor Pressure1.85 [mmHg]
Physical DescriptionWhite to light yellow crystalline powder with a slight ether-like odor; [Acros Organics MSDS]
Physikochemische Eigenschaften
- Schmelzpunkt
- 65 · 65-70 °C (lit.)
- Siedepunkt
- 162.5 °C · 162.5 °C (lit.)
- Dichte
- 1.4176 · 1.4176 (estimate)
- Flammpunkt
- 162 · 162-164°C
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
Warning
H302 (27.8%): Harmful if swallowed [Warning Acute toxicity, oral]
P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 151 reports by companies from 13 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Gefahrenhinweise
Regulatory Information
Status: Active Update: 08-03-2018 https://echa.europa.eu/registration-dossier/-/registered-dossier/12379
2,2,2-Trifluoroacetamide: Does not have an individual approval but may be used under an appropriate group standard
Hazards SummaryA skin and strong eye irritant; Harmful by ingestion; [ECHA REACH Registrations] An irritant; [Acros Organics MSDS] See Chloroacetamide and Fluoroacetamide.
Hazard Classes and CategoriesAcute Tox. 4 (27.8%)
Sicherheitsdaten
- wgk
- 3
- tsca
- TSCA listed
- ridadr
- 1759
- hs_code
- 2924199090
- risk_code
- 36/37/38
- hazard_code
- Xi
- hazard_note
- Harmful/Irritant
- safety_code
- 26-36-37/39
Chemie und Industrie
Verwendung und Herstellung
UsesUsed as an intermediate in fine chemical manufacture and in scientific research and development; [ECHA REACH Registrations]
General Manufacturing InformationAcetamide, 2,2,2-trifluoro-: ACTIVE
Anwendungen
Verwenden2,2,2-Trifluoroacetamide used in a convenient alternative to the Gabriel synthesis of primary amines from halides by N-alkylation followed by cleavage of the readily-hydrolyzed trifluoroacetyl group and for improved N-alkylation under phase-transfer conditions allowing successive alkylation with different alkyl groups.
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