HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Phensuximid
pm334 · Milontin · Lifen · Epimid · Lifene · PM 334 · Epimal · Mirotin
Identifikatoren & physikalische Daten
| CAS No. | 86-34-0 |
|---|---|
| Summenformel | C11H11NO2 |
| Durchschnittliche Molmasse | 189,21 g/mol |
| Monoisotopische Masse | 189,07897859 g/mol |
| SMILES | CN1C(=O)CC(c2ccccc2)C1=O |
| InChIKey | WLWFNJKHKGIJNW-UHFFFAOYSA-N |
| PubChem CID | 6839 |
| ChEMBL | CHEMBL797 |
| ChEBI | CHEBI:8079 |
| EC No. | 201-664-6 |
| DTXSID | DTXSID4023460 |
| Lokaler Name | Phensuximid |
Chemische & physikalische Eigenschaften
| XLogP | 0,8 |
|---|---|
| Polarare Oberfläche (TPSA) | 37,4 |
| H-Brücken-Donoren | 0 |
| H-Brücken-Akzeptoren | 2 |
| Frei drehbare Bindungen | 1 |
| Schwere Atome | 14 |
| Formalladung | 0 |
| Komplexität | 256 |
| Schmelzpunkt | 71-73° |
| Siedepunkt | 324.47°C (rough estimate) |
| Dichte | 1.1596 (rough estimate) |
| Brechungsindex | 1.5012 (estimate) |
| Lagerbedingungen | Refrigerator |
| Löslichkeit | Chloroform (Slightly), Ethyl Acetate (Slightly)4.2g/L(25 ºC) |
| Aggregatzustand | Solid |
| pKa (Säurekonstante) | -1.86±0.40(Predicted) |
| Farbe | White to Off-White |
Sicherheit & Vorschriften
| Zollcode | 2925190100 |
|---|---|
| Toxizität | LD50 orally in mice: 960 mg/kg (Chen, Ensor) |
Anwendungen & Verwendung
Beschreibung
Phensuximide is an anticonvulsant. It inhibits seizures induced by maximal electroshock (MES) and pentylenetetrazole in mice (ED50s = 112 and 50 mg/kg, respectively). Phensuximide (1.25 mmol/kg, i.p.) induces proteinuria and hematuria in rats. Formulations containing phensuximide have been used in the treatment of petit mal seizures.
Verwenden
Phensuximide, like ethosuximide, is an anticonvulsant drug used in minor forms of epilepsy.