Amiloride Hydrochloride

FDA approved drugs -> Active ingredient

FDA approved drugs -> Active ingredient

Danger

H300 (90.2%): Fatal if swallowed [Danger Acute toxicity, oral]

P264, P264+P265, P270, P273, P280, P301+P316, P305+P351+P338, P321, P330, P337+P317, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 41 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Amiloride hydrochloride: Does not have an individual approval but may be used under an appropriate group standard

Amiloride hydrochloride: Does not have an individual approval but may be used under an appropriate group standard

SYMPTOMS: Symptoms of exposure to this compound include headache, weakness, fatigue, back, chest, neck, shoulder or extremity pain; nausea, anorexia, vomiting, abdominal pain, hyperkalemia, paresthesias, shock, dizziness, coughing, shortness of breath, depression, nervousness, flaccid paralysis of the extremities, bradycardia, flatulence, skin rash, gas pain, constipation and dyspnea. (NTP, 1992)

A halide- and amine-substituted aromatic compound, with amide and acidic salt components. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. Organic amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).

AMILORIDE HYDROCHLORIDE

Decreased Renal K+ Excretion [PE]; Potassium-sparing Diuretic [EPC]; Increased Diuresis [PE]

Agents that promote the excretion of urine through their effects on kidney function.

A subclass of sodium channel blockers that are specific for ACID-SENSING SODIUM CHANNELS.

A subclass of sodium channel blockers that are specific for EPITHELIAL SODIUM CHANNELS.