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HCID 68552Erstellt: 4. November 2026

Guanadrel Sulfate

Anarel · Hylorel · U-28288D · CL-1388R · Hyloride · CHEBI:5556 · Guanadrel HeMisulfate · GUANADREL SULFATE (200 MG)

https://huagongshe.com/de/chemical/68552

Molekülstruktur von Guanadrel Sulfate

Identifikatoren & physikalische Daten

CAS No.22195-34-2
SummenformelC20H40N6O8S
Durchschnittliche Molmasse524,6 g/mol
Monoisotopische Masse524,26283343 g/mol
SMILESNC(N)=NCC1COC2(CCCCC2)O1.NC(N)=NCC1COC2(CCCCC2)O1.O=S(=O)(O)O
InChIKeyRTEVGQJRTFFMLL-UHFFFAOYSA-N
PubChem CID68552
ChEMBLCHEMBL3184143
ChEBICHEBI:5556
DTXSIDDTXSID8045432

Chemische & physikalische Eigenschaften

Polarare Oberfläche (TPSA)249
H-Brücken-Donoren6
H-Brücken-Akzeptoren10
Frei drehbare Bindungen4
Schwere Atome35
Formalladung0
Komplexität326
Color/FormWhite to off-white crystalline powderCrystals from methanol/ethanol
LöslichkeitIn water, 76 mg/ml @ 25 °C
Human DrugsFDA approved drugs -> Active ingredient
Schmelzpunkt213.5-215 °C213.5-215°
Stability/Shelf LifeGuanadrel sulfate tablets should be stored in well-closed containers at a temperature less than 40 °C, preferably between 15-30 °C.

Sicherheit & Vorschriften

FDA-AnforderungenThe Approved Drug Products with Therapeutic Equivalence Evaluations List identifies currently marketed prescription drug products, incl guanadrel sulfate, approved on the basis of safety and effectiveness by FDA under sections 505 of the Federal Food, Drug, and Cosmetic Act.
EntsorgungsverfahrenSRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.
WechselwirkungenTricyclic antidepressants, phenothiazines, and indirect-acting sympathomimetics (eg, ephedrine, phenylpropanolamine) may block the uptake of guanadrel into adrenergic neurons or reverse the hypotensive effect of guanadrel. Ephedrine has been shown to rapidly reverse the pharmacologic effects of guanadrel. Guanadrel may potentiate the pharmacologic activity of direct-acting sympathomimetic agents such as norepinephrine or phenylephrine.Monoamine oxidase inhibitors reportedly antagonize the hypotensive effect of guanadrel... guanadrel is contraindicated in patients receiving MAO inhibitors and that these drugs should be discontinued for at least 1 week prior to administration of guanadrel.Vasopressors should be administered with caution since guanadrel may enhance the pressor and arrhythmogenic responses to these drugs.Caution should be exercised when tricyclic antidepressant therapy is discontinued in patients receiving guanadrel, particularly if discontinuance of the antidepressant is abrupt, since enhanced clinical effects (e.g., hypotension) of guanadrel may occur. Because many nonprescription cold, allergy, and asthma preparations contain sympathomimetic agents, patients receiving guanadrel should be warned not to use these preparations for self-medication unless first consulting with their physician or pharmacist.For more Interactions (Complete) data for GUANADREL SULFATE (6 total), please visit the HSDB record page.
Human Toxicity Excerpts/HUMAN EXPOSURE STUDIES/ Overdosage of guanadrel produces symptoms that are mainly extensions of common adverse effects including postural hypotension with dizziness, blurred vision, and syncope when standing.
Non-Human Toxicity Excerpts/LABORATORY ANIMALS: Chronic Exposure or Carcinogenicity/ No evidence of carcinogenic potential appeared in a 2 yr mouse study of guanadrel sulfate. In a 2 yr rat study, an increased number of benign testicular interstitial cell tumors was observed at dosages of 100 mg/kg/day and 400 mg/kg/day.

Anwendungen & Verwendung

Verwenden

Guanadrel is an orally active postganglionic sympathetic inhibitor. Guanadrel HeMisulfate is used as an antihypertensive.

/LABORATORY ANIMALS: Developmental or Reproductive Toxicity/ A reproduction study was performed in male and female rats at dosages of 0, 10, 30, 100 mg/kg/day. Suppresed libido and reduced fertility were noted at 100 mg/kg/day and libido was suppressed to a lesser extent at 30 mg/kg/day.
/LABORATORY ANIMALS: Developmental or Reproductive Toxicity/ Teratology studies performed in rats and rabbits at doses up to 12 times the maximum recommended human dose (in a 50 kg subject) revealed no significant harm to the fetus due to guanadrel sulfate.
/GENOTOXICITY/ Salmonella testing (Ames test) showed no evidence of mutagenic activity.
Antidote and Emergency TreatmentThe most important complication of overdose being profound hypotension (usually orthostatic). ...Hypotension should be treated by the use of Trendelenburg position, and iv fluids should be administered when necessary....The effect of activated charcoal in adsorbing guanadrel in the GI tract and decreasing the drug's absorption has not been determined. Management of guanadrel overdosage includes keeping the patient supine and other symptomatic treatment. If excessive hypotension persists despite symptomatic treatment, more intensive supportive care may be required. If vasopressors are necessary, phenylephrine may be used, but it should be administered cautiously and in small doses because patients may be hypersensitive to phenylephrine's pharmacologic effects.Given that tolazoline treatment is variably successful and that most physicians are unfamiliar with this agent, it cannot be recommended in the primary management strategy... . It should be considered only after tactile stimulation, naloxone, atropine, iv fluids, and dopamine have failed.If the patient presents early or after a massive overdose, paradoxical hypertension may occur. It is typically self-limited and is routinely followed by profound hypotension. If severe or prolonged then treatment with a short-acting antihypertensive such as sodium nitroprusside is appropriate.Appropriate therapy begins with particular focus on the patient's respiratory and hemodynamic status. Administration of activated charcoal is the primary mode of gastrointestinal decontamination. Emesis... is contraindicated. Lavage has limited utility... . All patients with CNS depression should be routinely evaluated for hypoxia and hypoglycemia. Respiratory compromise, including apnea, often responds well to simple auditory or tactile stimulation. ...Endotracheal intubation may be required.
Non-Human Toxicity ValuesLD50 Rat oral 2220 mg/kgLD50 Rat iv 26 mg/kgLD50 Dog oral 225 mg/kgLD50 Dog iv 45 mg/kgFor more Non-Human Toxicity Values (Complete) data for GUANADREL SULFATE (6 total), please visit the HSDB record page.
Gefahrstoffdaten22195-34-2(Hazardous Substances Data)