Toltrazuril
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Grundinformationen
- CAS
69004-03-1- Standard-SMILES
Cc1cc(-n2c(=O)[nH]c(=O)n(C)c2=O)ccc1Oc1ccc(SC(F)(F)F)cc1- InChIKey
OCINXEZVIIVXFU-UHFFFAOYSA-N- Summenformel
- C18H14F3N3O4S
- Durchschnittliche Molmasse
- 425,388 g/mol
- Monoisotopische Masse
- 425,06571159
Namen und Bezeichner
- Bevorzugter Name
- Toltrazuril
- IUPAC
- 1-Methyl-3-(3-methyl-4-{4-[(trifluoromethyl)sulfanyl]phenoxy}phenyl)-1,3,5-triazinane-2,4,6-trione
- Englischer Name
- Toltrazuril
- Summenformel
- C18H14F3N3O4S
- Molmasse
- 425.38
Namen und Synonyme
MARIGOLD OLEORESINToltrazuilToltrazuri1-methyl-3-[3-methyl-4-[4-(trifluoromethylthio)phenoxy]phenyl]-1,3,5-triazinane-2,4,6-trioneBAYCOX1-METHYL-3-[3-METHYL-4-[4-(TRIFLUOROMETHYLTHIO)PHENOXY]PHENYL]-1,3,5-TRIAZINE-2,4,6(1H,3H,5H)-TRIONEBaycox, 1-Methyl-3-{3-methyl-4-[4-(trifluoromethylthio)phenoxy]phenyl}-1,3,5-triazine-2,4,6(1H,3H,5H)-trionetrazuriLbay-i9142TOLRAZURIL
Datenbank-Bezeichner
- CAS
69004-03-1- PubChem CID
- 68591
- DTXSID
DTXSID90219063- ChEMBL
CHEMBL2104931- ChEBI
CHEBI:93130- UNII
- QVZ3IAR3JS
- EC Number
- 614-893-5
- Nikkaji
- J22.790K
Eigenschaften
Physikochemische Eigenschaften
- Schmelzpunkt
- 194 · 194-196°C
- Dichte
- 1.54 · 1.54±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- Löslichkeit
- 1 mg/ml · Toltrazuril is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF), which should be purged with an inert gas. The solubility of toltrazuril in ethanol is approximately 1 mg/ml and approximately 25 mg/ml in DMSO and DMF.
- pka
- 6.47 · 6.47±0.20(Predicted)
- Aggregatzustand
- Solid
- Farbe
- White to off-white
- Major Application
- forensics and toxicologypharmaceutical (small molecule)
- InChI
- InChI=1S/C18H14F3N3O4S/c1-10-9-11(24-16(26)22-15(25)23(2)17(24)27)3-8-14(10)28-12-4-6-13(7-5-12)29-18(19,20)21/h3-9H,1-2H3,(H,22,25,26)
- InChIKey
- OCINXEZVIIVXFU-UHFFFAOYSA-N
- SMILES
- N1(C)C(=O)NC(=O)N(C2=CC=C(OC3=CC=C(SC(F)(F)F)C=C3)C(C)=C2)C1=O
- CAS Datenbank
- 69004 · 69004-03-1(CAS DataBase Reference)
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
Sicherheitsdaten
- wgk
- 2
- ridadr
- UN 3077
- hs_code
- 29336990
- risk_code
- 50/53-36/37/38
- hazard_code
- N,Xi
- safety_code
- 60-61-37/39-26
- Speicherklasse
- 11 - Combustible Solids
- Hazard Classifications
- Aquatic Acute 1Aquatic Chronic 1
Chemie und Industrie
Anwendungen
BeschreibungToltrazuril (Baycox®,Procox®) is a triazinon drug thathas broad-spectrum anticoccidial and antiprotozoalactivity. It is not commercially available in the UnitedStates, but it is available in other countries. It is activeagainst both asexual and sexual stages of coccidia byinhibiting nuclear division of schizonts and microga-monts and the wall-forming bodies of macrogamonts. Itmay also be useful in the treatment of neonatal porcinecoccidiosis, EPM, and canine hepatozoonosis. Toltrazuril and its major metabolite ponazuril (toltrazuril sulfone, Marquis) are triazine-based antiprotozoal drugs that have specific activity against apicomplexan coccidial infections. Toltrazuril is not available within the United States.
VerwendenToltrazuril is an antiprotozoal agent that is widely used to prevent coccidia parasite infection in veterinary applications. The effectiveness of treatment appears to depend on the coccidian species, development stage of the parasite, and level of infection.
VerwendenLabelled analog of a triazinetrione anticoccidial. Coccidiostat. Toltrazuril is found to be highly effective against coccidia and is used in controlling coccidiosis. It is acting against all intracellular development stages of coccidia of the merogony (asexual multiplication) and gamogony (sexual phase). All stages are destroyed, thus the mode of action is coccidiocidal.
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上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
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