Phenoxymethylpenicillin

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SMALL SPILLS AND LEAKAGE: Should a spill occur while you are handling this chemical, FIRST REMOVE ALL SOURCES OF IGNITION. You should then dampen the solid spill material with ethanol, and transfer the dampened material to a suitable container. Use absorbent paper dampened with ethanol to pick up any remaining material. Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

Oral neomycin has been shown to decrease the absorption of penicillin V ... .

Since penicillin acts by inhibiting cell wall synthesis, agents which inhibit protein synthesis (eg, chloramphenicol) could ... mask the bactericidal effect of penicillin. /Penicillin/

Since penicillin acts by inhibiting cell wall synthesis, agents which inhibit protein synthesis (eg, erythromycin) could ... mask the bactericidal effect of penicillin. ... Clinical evidence exists for erythromycin-penicillin antagonism in patients with group A hemolytic streptococcal pharyngitis. ... The possibility of antagonism exists, but it has not been sufficiently documented in clinical studies. /Penicillin/

Tetracyclines ... may interfere with a bactericidal agent such as penicillin. /Penicillin/

For more Interactions (Complete) data for PENICILLIN V (16 total), please visit the HSDB record page.

Hypersensitivity reactions are one of the most frequent adverse reactions to penicillin G & penicillin V. In addition ... oral admin ... is frequently associated with adverse GI effects.

In addition to eosinophilia & hemolytic anemia ... other adverse hematologic effects including transient neutropenia, leukopenia, thrombocytopenia, & thrombocytopenic purpura have occurred rarely in patients receiving penicillin G or penicillin V. These hematologic reactions occur most frequently when high doses of penicillin G are admin IV & are generally reversible following discontinuance of the drugs. ... Some or the most frequent adverse reactions to orally admin penicillin ... V are GI effects including nausea, vomiting, epigastric distress & diarrhea.

Skin rashes of all types may be caused by allergy to penicillin. Scarlatiniform, morbilliform, urticarial, vesicular, and bullous eruptions may develop. Purpuric lesions are uncommon & are usually the result of a vasculitis ... Henoch-Schoenlein purpura with renal involvement has been a rare complication. ... The most serious hypersensitivity reactions produced by the penicillins are angioedema and anaphylaxis. Angioedema with marked swelling of the lips, tongue, face, & periorbital tissues, frequently accompanied by asthmatic breathing & "giant hives" ... observed after topical, oral or systemic admin of penicillins of various types. ... Anaphylactoid reactions may occur at any age. ... About 0.002% of patients treated with these agents die from anaphylaxis. It has been estimated that there are at least 300 deaths per yr due to this complication of therapy. /Penicillins/

Anaphylaxis has most often followed the injection of penicillin, although it has also been observed after oral ingestion of the drug, & has even resulted from the intradermal instillation of a very small quantity for the purpose of testing for the presence of hypersensitivity. ... The most dramatic /clinical picture/ is sudden, severe hypotension & rapid death. ... Bronchoconstriction with severe asthma, or abdominal pain, nausea, and vomiting, or extreme weakness & fall in blood pressure, or diarrhea & purpuric skin eruptions have characterized the anaphylactic episodes. Serum sickness varies from mild fever, rash, and leukopenia to severe arthralgia or arthritis, purpura, lymphadenopathy, splenomegaly, mental changes, ECG abnormalities suggestive of myocarditis, generalized edema, albuminuria, and hematuria. It is mediated by IgG antibodies. /Penicillins/

For more Human Toxicity Excerpts (Complete) data for PENICILLIN V (45 total), please visit the HSDB record page.

Drug-Induced Liver Injury Severity and Toxicity (DILIst)

penicillin v

DILI Negative

Oral

DOI:10.1016/j.drudis.2019.09.022

Oral Dosage Form New Animal Drugs. Specifications and conditions of use provided for dogs and cats. /Penicillin V potassium for oral solution/

Oral Dosage Form New Animal Drugs. Specifications and conditions of use provided for dogs and cats. /Penicillin V potassium tablets/

Manufacturers, packers, and distributors of drug and drug products for human use are responsible for complying with the labeling, certification, and usage requirements as prescribed by the Federal Food, Drug, and Cosmetic Act, as amended (secs 201-902, 52 Stat. 1040 et seq., as amended; 21 U.S.C. 321-392).

Used to prepare 6-APA on a large scale by selective enzymatic hydrolysis

MEDICATION

MEDICATION (VET)

Use (kg; approx.) in Germany (2009): >25000

Natural penicillins are produced by fermentation of mutant strains of Penicillium chrysogenum. ... Penicillin ... V /is/ produced by adding ... phenoxyacetic acid ... to the culture media.

Obtained by adding 2-phenoxyethanol to the Penicillium culture using yeast autolyzate as source of nitrogen.

... Penicillin V is commercially available as the acid and its potassium salt.

Generic: Powder for oral solution (plain, buffered) and oral suspension 125 and 250 mg/5 ml; tablets 250 and 500 mg.

Grade: NF

Although potency of penicillin V ... is generally expressed in terms of the weight of penicillin V, potency of the drugs may be expressed in terms of USP penicillin V units. For labeling purposes, each mg of penicillin V contained in penicillin V ... prepn is considered equivalent to 1695 penicillin V units.

The problem of antibiotic contamination of milk requires that the dairy operator, veterinarian, and milk processor be aware of the sensitizing ability of penicillin and the importance of adherence to drug withdrawal times. /Penicillins/