Brodimoprim
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Grundinformationen
- CAS
56518-41-3- Standard-SMILES
COc1cc(Cc2cnc(N)nc2N)cc(OC)c1Br- InChIKey
BFCRRLMMHNLSCP-UHFFFAOYSA-N- Summenformel
- C13H15BrN4O2
- Durchschnittliche Molmasse
- 339,193 g/mol
- Monoisotopische Masse
- 338,03783782
Namen und Bezeichner
- Bevorzugter Name
- Brodimoprim
- IUPAC
- 5-[(4-Bromo-3,5-dimethoxyphenyl)methyl]pyrimidine-2,4-diamine
- Lokaler Name
- Brodimoprim
- Englischer Name
- Brodimoprim
- Summenformel
- C13H15BrN4O2
- Molmasse
- 339.1878
Namen und Synonyme
HypriMUnitriMRo-10-5970BromodiprimBromidoprimbrodimoprimBromopropylbromdimoprimHyprim：UnitrimBrodimoprim USP/EP/BP
Datenbank-Bezeichner
- CAS
56518-41-3- PubChem CID
- 68760
- DTXSID
DTXSID20205070- ChEMBL
CHEMBL31891- ChEBI
CHEBI:131726- UNII
- V1YC7T6LLI
- EC Number
- 260-238-8
- Nikkaji
- J12.610A
Eigenschaften
Physikochemische Eigenschaften
- Schmelzpunkt
- 225 · 225-228°
- storage temp.
- -20 °C · Amber Vial, -20°C Freezer, Under inert atmosphere
- Löslichkeit
- DMSO (Slightly), Methanol (Sparingly)
- pka
- 7.15 · 7.15(at 25℃)
- Aggregatzustand
- Solid
- Farbe
- White to Pale Yellow
- Stabilität
- Light Sensitive
Chemie und Industrie
Anwendungen
BeschreibungBrodimoprim, a dihydrofolate reductase inhibitor, was introduced for the treatment of common infections of upper respiratory tract such as sinusitis and exacerbation of chronic bronchitis. It has a broad spectrum of antimicrobial activities against most Gram-positive and -negative pathogens including some bacterial strains that are resistant to amoxicillin, a widely used antibiotic for the indicated infections. Brodimoprim also has a favorable pharmacokinetic profile exemplified by its long half-life and good tissue penetration.
VerwendenA structural derivative of Trimethoprim (T795615). A selective dihydrofolate reductase inhibitor; diaminopyridine antibacterial agent.
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陕西缔都新材料有限公司81124267 17392282731 · [email protected]
Career Henan Chemica Co+86-0371-86658258 +86-13203830695 · [email protected]
艾吉析科技（上海）有限公司17717235263 · [email protected]
上海麦克林生化科技股份有限公司021-50706066 15221275939 · [email protected]
上海毕得医药科技股份有限公司400-1647117 13681763483 · [email protected]
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