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HCID 68827Erstellt: 27. Oktober 2026

Artemisinin

https://huagongshe.com/de/chemical/68827

Identifikatoren & physikalische Daten

CAS No.	119241-68-8
Summenformel	C15H22O5
Durchschnittliche Molmasse	282,33 g/mol
SMILES	C[C@@H]1CC[C@H]2[C@@H](C)C(=O)O[C@@H]3O[C@@]4(C)CC[C@@H]1[C@]32OO4
InChIKey	BLUAFEHZUWYNDE-NNWCWBAJSA-N
PubChem CID	68827
ChEMBL	CHEMBL269671
ChEBI	CHEBI:223316
EC No.	700-290-5
DTXSID	DTXSID2040652

Chemische & physikalische Eigenschaften

XLogP	2,8
Polarare Oberfläche (TPSA)	54
H-Brücken-Donoren	0
H-Brücken-Akzeptoren	5
Frei drehbare Bindungen	0
Schwere Atome	20
Formalladung	0
Komplexität	452
Arzneimittel	Pharmaceuticals -> Listed in ZINC15
Lipide	Lipids -> Prenol Lipids [PR] -> Isoprenoids [PR01] -> C15 isoprenoids (sesquiterpenes) [PR0103]
LogP (Verteilungskoeffizient)	2.9
Collision Cross Section	168.1 Å² [M+Na]+ [CCS Type: TWMethod: calibrated with polyalanine and drug standards]167.28 Å² [M+K]+ [CCS Type: TW

Sicherheit & Vorschriften

GHS-Einstufung	This chemical does not meet GHS hazard criteria for 5.6% (2 of 36) of reports.DangerH242 (91.7%): Heating may cause a fire [Danger Self-reactive substances and mixturesOrganic peroxides]P210, P234, P235, P240, P273, P280, P370+P378, P391, P403, P410, P411, P420, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 36 reports by companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Regulatorische Informationen	Status: Active Update: 15-11-2012 https://echa.europa.eu/registration-dossier/-/registered-dossier/1057
Hazard Classes and Categories	Org. Perox. D (91.7%)
Toxizitätsübersicht	A 2025 systematic review notes that although Artemisinin is generally regarded as being well-tolerated, ico-administration with other pharmacological agents should be carefully monitored. In animal-focused studies, Artemisinin led to neurotoxicity (affecting brain matter and nuclei), cardiotoxicity (slower heart rate and prolonged QTc interval), hematotoxicity (low counts of white blood cells and platelets), and genotoxicity, embryotoxicity, and nephrotoxicity.
Drug Induced Liver Injury	Drug-Induced Liver Injury Severity and Toxicity (DILIst)ArtemisininDILI PositiveDOI:10.1016/j.drudis.2019.09.022

CAS No.

119241-68-8

Summenformel

C15H22O5

Durchschnittliche Molmasse

282,33 g/mol

SMILES

C[C@@H]1CC[C@H]2[C@@H](C)C(=O)O[C@@H]3O[C@@]4(C)CC[C@@H]1[C@]32OO4

InChIKey

BLUAFEHZUWYNDE-NNWCWBAJSA-N

PubChem CID

68827

ChEMBL

CHEMBL269671

ChEBI

CHEBI:223316

EC No.

700-290-5

DTXSID

DTXSID2040652

Chemische & physikalische Eigenschaften

XLogP

2,8

Polarare Oberfläche (TPSA)

H-Brücken-Donoren

H-Brücken-Akzeptoren

Frei drehbare Bindungen

Schwere Atome

Formalladung

Komplexität

452

Arzneimittel

Pharmaceuticals -> Listed in ZINC15

Lipide

Lipids -> Prenol Lipids [PR] -> Isoprenoids [PR01] -> C15 isoprenoids (sesquiterpenes) [PR0103]

LogP (Verteilungskoeffizient)

2.9

Collision Cross Section

168.1 Å² [M+Na]+ [CCS Type: TWMethod: calibrated with polyalanine and drug standards]167.28 Å² [M+K]+ [CCS Type: TW

Sicherheit & Vorschriften

GHS-Einstufung

This chemical does not meet GHS hazard criteria for 5.6% (2 of 36) of reports.DangerH242 (91.7%): Heating may cause a fire [Danger Self-reactive substances and mixturesOrganic peroxides]P210, P234, P235, P240, P273, P280, P370+P378, P391, P403, P410, P411, P420, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 36 reports by companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Regulatorische Informationen

Status: Active Update: 15-11-2012 https://echa.europa.eu/registration-dossier/-/registered-dossier/1057

Hazard Classes and Categories

Org. Perox. D (91.7%)

Toxizitätsübersicht

A 2025 systematic review notes that although Artemisinin is generally regarded as being well-tolerated, ico-administration with other pharmacological agents should be carefully monitored. In animal-focused studies, Artemisinin led to neurotoxicity (affecting brain matter and nuclei), cardiotoxicity (slower heart rate and prolonged QTc interval), hematotoxicity (low counts of white blood cells and platelets), and genotoxicity, embryotoxicity, and nephrotoxicity.

Drug Induced Liver Injury

Drug-Induced Liver Injury Severity and Toxicity (DILIst)ArtemisininDILI PositiveDOI:10.1016/j.drudis.2019.09.022