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Grundinformationen
- CAS
602-56-2- Standard-SMILES
c1ccc(-c2c3ccccc3nc3ccccc23)cc1- InChIKey
MTRFEWTWIPAXLG-UHFFFAOYSA-N- Summenformel
- C19H13N
- Durchschnittliche Molmasse
- 255,32 g/mol
- Monoisotopische Masse
- 255,10479942
Namen und Bezeichner
- Bevorzugter Name
- Acridine, 9-phenyl-
- IUPAC
- 9-Phenylacridine
- Lokaler Name
- 9-Phenylacridin
- Englischer Name
- 9-Phenylacridine
- Summenformel
- C19H13N
- Molmasse
- 255.31
Namen und Synonyme
9-PAPI-9-PAphenylacridine9-PHENYLACRIDINE9-phenyl-acridin9-Phenylacridine>Acridine, 9-phenyl-9-Phenylacridin (9-PA)3-propan-2-yloxy-1-cyclohex-2-enoneTIANFU-CHEM CAS:602-56-2 9-Phenylacridine
Datenbank-Bezeichner
- CAS
602-56-2- PubChem CID
- 69041
- DTXSID
DTXSID00870669- ChEMBL
CHEMBL332209- EC Number
- 210-020-3
- Nikkaji
- J79.701D
Eigenschaften
Physikochemische Eigenschaften
- Schmelzpunkt
- 184 °C · 184°C
- Siedepunkt
- 388.54 °C · 388.54°C (rough estimate)
- Dichte
- 0.9418 · 0.9418 (rough estimate)
- Brechungsindex
- 1.65 · 1.6500 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- Aggregatzustand
- powder to crystal
- pka
- 5.45 · 5.45±0.10(Predicted)
- Farbe
- Light yellow to Amber to Dark green
- InChI
- InChI=1S/C19H13N/c1-2-8-14(9-3-1)19-15-10-4-6-12-17(15)20-18-13-7-5-11-16(18)19/h1-13H
- InChIKey
- MTRFEWTWIPAXLG-UHFFFAOYSA-N
- SMILES
- C1C2C(=NC3C(C=2C2=CC=CC=C2)=CC=CC=3)C=CC=1
- CAS Datenbank
- 602 · 602-56-2(CAS DataBase Reference)
- NIST chemische Informationen
- 9 · Acridine, 9-phenyl-(602-56-2)
- EPA chemische Informationen
- 9 · Acridine, 9-phenyl- (602-56-2)
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
Sicherheitsdaten
- tsca
- TSCA listed
- hs_code
- 2933.99.8210
- safety_code
- 22-24/25
Chemie und Industrie
Anwendungen
VerwendenResearch has found that 9-phenylacridine (ACPH) exhibited anticancer activity in cell lines and in vivo animal models. Bioinformatics studies have indicated that it could have topoisomerase I inhibitory activity. It could also act as a PARP 1 inhibitor and was very effective in combination with cisplatin in cell line-based assays. ACPH also satisfied all criteria for a candidate drug from the Lipinski rule and showed good cell uptake. ACPH alone was effective in the A375 melanoma cell line. ACPH could be used as a promising new photosensitizer[1-2]. 9-Phenylacridine is the parent base of chrysaniline or 3,6-diamino-9- phenylacridine, the chief constituent of the dyestuff phosphine. It is commonly used in the electronics industry as a free radical photoinitiator, significantly improving photo speed.
Beschreibung9-Phenylacridine has antitumour activity. It can be used as a photosensitiser and can sensitise UVA-induced DNA damage in vitro and in cells. It also enhances cell killing by UVA. In addition. It is also used in photochemical research and as a raw material for organic synthesis.
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