Flibanserin
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Grundinformationen
- CAS
167933-07-5- Standard-SMILES
O=c1[nH]c2ccccc2n1CCN1CCN(c2cccc(C(F)(F)F)c2)CC1- InChIKey
PPRRDFIXUUSXRA-UHFFFAOYSA-N- Summenformel
- C20H21F3N4O
- Durchschnittliche Molmasse
- 390,409 g/mol
- Monoisotopische Masse
- 390,16674595
Namen und Bezeichner
- Bevorzugter Name
- Flibanserin
- IUPAC
- 1-(2-{4-[4-(Trifluoromethyl)phenyl]piperazin-1-yl}ethyl)-1,3-dihydro-2H-benzimidazol-2-one
- Englischer Name
- Flibanserin
- Summenformel
- C20H21F3N4O
- Molmasse
- 390.4
Namen und Synonyme
FilbanserinFlibanserineBIMTNiemunerkeine1,3-Dihydro-1-[2-[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]ethyl]-2H-benzimidazol-2-oneGirosaBimt 17FbanselinBIMT 17BSFlubanserin
Datenbank-Bezeichner
- CAS
167933-07-5- PubChem CID
- 6918248
- DTXSID
DTXSID30168445- ChEMBL
CHEMBL231068- ChEBI
CHEBI:90865- UNII
- 37JK4STR6Z
- EC Number
- 643-002-2
- Nikkaji
- J672.705K
Eigenschaften
Physikochemische Eigenschaften
- Dichte
- 1.292 · 1.292±0.06 g/cm3(Predicted)
- storage temp.
- 2 · 2-8°C
- Löslichkeit
- 10 mg/mL, · DMSO: soluble10mg/mL, clear
- Aggregatzustand
- powder
- pka
- 12.12 · 12.12±0.30(Predicted)
- Farbe
- white to beige
- InChI
- InChI=1S/C20H21F3N4O/c21-20(22,23)15-4-3-5-16(14-15)26-11-8-25(9-12-26)10-13-27-18-7-2-1-6-17(18)24-19(27)28/h1-7,14H,8-13H2,(H,24,28)
- InChIKey
- PPRRDFIXUUSXRA-UHFFFAOYSA-N
- SMILES
- C1(=O)N(CCN2CCN(C3=CC=CC(C(F)(F)F)=C3)CC2)C2=CC=CC=C2N1
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
Sicherheitsdaten
- wgk
- 3
- ridadr
- UN 2811 6.1 / PGIII
- risk_code
- 25-36/37/38
- hazard_code
- T
- safety_code
- 26-45
- Speicherklasse
- 6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects
- Giftige Stoffe Daten
- 167933-07-5(Hazardous Substances Data)
- Hazard Classifications
- Acute Tox. 3 OralEye Irrit. 2Skin Irrit. 2STOT SE 3
Chemie und Industrie
Anwendungen
BeschreibungFlibanserin is a drug originally developed by Boehringer-Ingelheim and later Sprout Pharmaceuticals, which was approved in 2015 by the FDA for the treatment of premenopausal women with hypoactive sexual desire disorder (HSDD). The drug, which was originally developed for the treatment of depression by Boehringer- Ingelheim, is a full agonist of the 5-HT1A receptor, an antagonist of the 5-HT2A receptor, and a partial agonist of the dopamine-4 (D4) receptor, which triggers increased dopamine and norepinephrine levels along with decreased serotonin levels. In three randomized trials involving 2400 premenopausal women, the drug was found to increase the number of satisfying sexual events by 0.5-1.0 events per month and increased sexual desire on average by 10-12% over placebo. Side effects include decreased blood pressure and loss of consciousness, especially in subjects who consumed alcohol.
VerwendenAntidepressant (5-HT1a agonist and 5-HT2 antagonist).
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