Desvenlafaxine Succinate
Grundinformationen
- CAS
386750-22-7- Standard-SMILES
CN(C)CC(c1ccc(O)cc1)C1(O)CCCCC1.O.O=C(O)CCC(=O)O- InChIKey
PWPDEXVGKDEKTE-UHFFFAOYSA-N- Summenformel
- C20H33NO7
- Durchschnittliche Molmasse
- 399,5 g/mol
- Monoisotopische Masse
- 399,2257024
Überblick
Desvenlafaxine Succinate is the succinate salt form of desvenlafaxine, a synthetic phenethylamine bicyclic derivative with antidepressant activity. Desvenlafaxine is a selective reuptake inhibitor of serotonin and norepinephrine due to its high binding affinities to the pre-synaptic serotonin and norepinephrine transporters. By blocking both transporters, this agent prolongs neurotransmitter activities of both serotonin and norepinephrine, thereby alleviating depressive state.
Namen und Bezeichner
- Bevorzugter Name
- Desvenlafaxine Succinate
- IUPAC
- butanedioic acid;4-[2-(dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol;hydrate
- Englischer Name
- Desvenlafaxine succinate Monohydrate
- Summenformel
- C20H31NO6
- Molmasse
- 381.47
Namen und Synonyme
386750-22-7PristiqDesvenlafaxine succinate monohydrateDesvenlafaxine succinate hydrateDVS-233ZB22ENF0XRWy-45233Wy 45233DTXSID70959511O-DESMETHYL VENLAFAXINE SUCCINATEO-desmethylvenlafaxine Succinate MonohydrateButanedioic acid, compound with 4-(2-(dimethylamino)-1-(1-hydroxycyclohexyl)ethyl)phenol (1:1), monohydrate
Weitere Namen anzeigen
Desvenlafaxine succinateO-Desmethylvenlafaxine succinate hydrateUnii-zb22enf0xrWY 45233 succinateDesvenla succinateNorvenlafaxine succinatePristiq succinate hydrateC16H25NO2.HOOCCH2CH2COOH.H2ODesvenlafaxine (succinate hydrate)
DESVENLAFAXINE ERPristiq Extended-releaseRefChem:57730Succinate, DesvenlafaxineO desmethylvenlafaxine SuccinateSuccinate, O-desmethylvenlafaxineDTXCID301436158WY45,233
Datenbank-Bezeichner
Eigenschaften
Berechnete Struktureigenschaften
- Polarare Oberfläche (TPSA)
- 119 Ų
- H-Brücken-Donoren
- 5
- H-Brücken-Akzeptoren
- 8
- Frei drehbare Bindungen
- 7
- Schwere Atome
- 28
- Formalladung
- 0
- Komplexität
- 359
Experimentelle und physikochemische Eigenschaften
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
Physikochemische Eigenschaften
- storage temp.
- 4 °C · Store at +4°C
- Löslichkeit
- 3 · DMSO:3.0(Max Conc. mg/mL);7.51(Max Conc. mM)
- Aggregatzustand
- Powder
- Farbe
- White to off-white
- Stabilität
- Hygroscopic
- Major Application
- pharmaceutical (small molecule)
- InChI
- InChI=1S/C16H25NO2.C4H6O4/c1-17(2)12-15(13-6-8-14(18)9-7-13)16(19)10-4-3-5-11-16;5-3(6)1-2-4(7)8/h6-9,15,18-19H,3-5,10-12H2,1-2H3;1-2H2,(H,5,6)(H,7,8)
- InChIKey
- ORUUBRMVQCKYHB-UHFFFAOYSA-N
- SMILES
- C(C(=O)O)CC(=O)O.C(C1C=CC(O)=CC=1)(C1(CCCCC1)O)CN(C)C
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
Warning
H302 (84%): Harmful if swallowed [Warning Acute toxicity, oral]
P264, P264+P265, P270, P280, P301+P317, P305+P351+P338, P330, P337+P317, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 50 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Gefahrenhinweise
Hazard Classes and CategoriesAcute Tox. 4 (84%)
Toxikologische Informationen
Drug Induced Liver Injury
Drug Induced Liver Injury Rank (DILIrank 2.0)
Desvenlafaxine succinate
vLess-DILI-concern
3
Adverse reactions
DOI:10.1016/j.drudis.2016.02.015
Sicherheitsdaten
- wgk
- WGK 3
- hs_code
- 2922504500
- Speicherklasse
- 11 - Combustible Solids
- Hazard Classifications
- Aquatic Chronic 3
Chemie und Industrie
Pharmakologische Informationen
FDA Pharmacological Classification
DESVENLAFAXINE ER
Cytochrome P450 2D6 Inhibitors [MoA]; Serotonin and Norepinephrine Reuptake Inhibitor [EPC]; Norepinephrine Uptake Inhibitors [MoA]; Serotonin Uptake Inhibitors [MoA]
DESVENLAFAXINE SUCCINATE
Cytochrome P450 2D6 Inhibitors [MoA]; Serotonin and Norepinephrine Reuptake Inhibitor [EPC]; Norepinephrine Uptake Inhibitors [MoA]; Serotonin Uptake Inhibitors [MoA]
MeSH Pharmacological Classification
Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE INHIBITORS are useful as antidepressants apparently as a long-term consequence of their modulation of catecholamine levels. The tricyclic compounds useful as antidepressive agents (ANTIDEPRESSIVE AGENTS, TRICYCLIC) also appear to act through brain catecholamine systems. A third group (ANTIDEPRESSIVE AGENTS, SECOND-GENERATION) is a diverse group of drugs including some that act specifically on serotonergic systems.
Drugs that selectively block or suppress the plasma membrane transport of SEROTONIN and NORADRENALINE into axon terminals and are used as ANTIDEPRESSIVE AGENTS.
Anwendungen
BeschreibungDesvenlafaxine Succinate is a dual serotonin and norepinephrine reuptake inhibitor (SNRI) that was approved for the treatment of major depressive disorder (MDD) in the United States in 2008. In order to improve the efficacy and safety profile of venlafaxine, Wyeth discovered and developed one of the major metabolites of venlafaxine, namely the O-desmethyl metabolite (desvenlafaxine). Desvenlafaxine is also being developed for the treatment of moderate to severe vasomotor symptoms associated with menopause (i.e., hot flashes and night sweats) and is also in phase III clinical trials to study it’s effectiveness in treating fibromyalgia and neuropathic pain.
VerwendenAntianxiety therapeutic
Anbieter100 Anbieter
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