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HCID 6950Erstellt: 4. November 2026

Dinoseb

https://huagongshe.com/de/chemical/6950

Molekülstruktur von Dinoseb

Identifikatoren & physikalische Daten

CAS No.88-85-7
SummenformelC10H12N2O5
Durchschnittliche Molmasse240,21 g/mol
Monoisotopische Masse240,07462149 g/mol
SMILESCCC(C)c1cc([N+](=O)[O-])cc([N+](=O)[O-])c1O
InChIKeyOWZPCEFYPSAJFR-UHFFFAOYSA-N
PubChem CID6950
ChEMBLCHEMBL1892987
ChEBICHEBI:83632
EC No.201-861-7
DTXSIDDTXSID3020207

Chemische & physikalische Eigenschaften

XLogP3,6
Polarare Oberfläche (TPSA)112
H-Brücken-Donoren1
H-Brücken-Akzeptoren5
Frei drehbare Bindungen2
Schwere Atome17
Formalladung0
Komplexität298
StoffklassenTeratogens
pHAN ACIDIC PHENOL
SpringerMaterials PropertiesFusion temperature
PestizidePesticide -> EPA IRISPesticides -> Herbicides, Nitroaromatic
LogP (Verteilungskoeffizient)3.563.693.57
GeruchPUNGENT ODOR
Dichte1.2647 at 113 °F (EPA, 1998) - Denser than waterwill sink1.2647 @ 45 °C/4 °CRelative density (water = 1): 1.3 (30 °C)1.265 @ 45°C1.2647 g/cm3(Temp: 45 °C)
Color/FormYellow crystalsOrange solid
Löslichkeit0.0052 G/100 G WATER48 G/100 G ETHANOL27 G/100 G N-HEPTANEMISCIBLE IN ETHYL ETHER, TOLUENE, & XYLENE0.052 mg/mL at 25 °CSolubility in water, g/100ml at 20 °C: 0.005 (very poor)
CorrosivityCORROSIVE TO MILD STEEL IN THE PRESENCE OF WATERFormulations are noncorrosive to equipment if cleaned after use.
Flammpunkt60.1 to 84.9 °F for 3 commercial products (EPA, 1998)15.6 °C, (CLOSED CUP) (DOW GENERAL WEED KILLER)18.9 °C, (CLOSED CUP) (DOW SELECTIVE WEED KILLER)>100 °C
Human DrugsPharmaceuticals
Schmelzpunkt38-42 °C
Siedepunkt332 °C
pKa (Säurekonstante)4.08±0.50(Predicted)

Sicherheit & Vorschriften

GHS-EinstufungDangerH301: Toxic if swallowed [Danger Acute toxicity, oral]P203, P262, P264, P264+P265, P270, P273, P280, P301+P316, P302+P352, P305+P351+P338, P316, P318, P321, P330, P337+P317, P361+P364, P391, P405, and P501 (click each P-code to see the statement)H300+H310+H330 (51.5%): Fatal if swallowed, in contact with skin or if inhaled [Danger Acute toxicity, oralacute toxicity, dermalacute toxicity, inhalation]P203, P260, P261, P262, P264, P264+P265, P270, P271, P272, P273, P280, P284, P301+P316, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P316, P317, P318, P320, P321, P330, P332+P317, P333+P317, P337+P317, P361+P364, P362+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement)
Regulatorische InformationenChemical: Phenol, 2-(1-methylpropyl)-4,6-dinitro-Phenol, 2-(1-methylpropyl)-4,6-dinitro- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Phenol, 2-(1-methylpropyl)-4,6-dinitro- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)REACH registered substance: Dinoseb (EC: 201-861-7)Substance: Dinoseb (6-sec-butyl-2,4-dinitrophenol)Phenol, 2-(1-methylpropyl)-4,6-dinitro-: Does not have an individual approval but may be used under an appropriate group standardThe New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)
DOT-KennzeichnungPoison
BrandgefahrenThis is a dinitrophenol herbicide. (Non-Specific -- Dinitrophenol, Flammable Solid). It is dangerously explosive. When not water wet it is a high explosive. Dry, the material is easily ignited and it will burn very vigorously. On decomposition, nitro compounds such as this emit toxic fumes. Appear to be stable in acid solution, but are susceptible to decomposition by ultraviolet radiation in alkaline solution. (EPA, 1998)Combustible. Liquid formulations containing organic solvents may be flammable. Gives off irritating or toxic fumes (or gases) in a fire. Risk of fire and explosion on confinement and exposure to high temperatures.
GesundheitsgefahrenExtremely toxic: Probable oral lethal dose is 5-50 mg/kgbetween 7 drops and 1 teaspoonful for 70 kg person (150 lb.). (EPA, 1998)
GefahrenübersichtThe pathophysiology, like that of pentachlorophenol, involves the uncoupling of oxidative phosphorylation. Yellow stains appear on the skin after dermal contact with the nitroaromatic herbicides. Fatal poisoning can occur after dermal absorption. Cataracts have been reported in animal experiments and after occupational exposure. In severe poisoning, these herbicides can cause injury to the liver and kidneys. [EPA Pesticides, p. 104-5] An eye irritantCan be absorbed through skinShort-term exposure may have effects on the GI tract and CNSProlonged or repeated exposure may affect the kidneys, liver, blood, immune system, and eyes (cataract)Aerosol exposure in hot environments may result in deathMay be a reproductive toxicant in humans[ICSC] A powerful oxidizing agent and explosiveExtremely toxic (enhanced by high ambient temperature and physical activity)[CAMEO]
Reaktive GruppeNitro, Nitroso, Nitrate, and Nitrite Compounds, Organic
EG-EinstufungSymbol: T, NR: 61-62-24/25-36-44-50/53S: 53-45-60-61Note: E
UN-EinstufungUN Hazard Class: 6.1UN Pack Group: II
Special ReportsREISH DJ ET ALJ WATER POLLUT CONTROL FED 50 (6): 1424-69 (1978). ACUTE TOXICOLOGICAL EFFECTS OF DINOSEB ARE DISCUSSED & BIOACCUMULATION & ENVIRONMENTAL RESIDUES OF VARIOUS PESTICIDES ARE REVIEWED.LAFORNARA JPJ WATER POLLUT CONTROL FED 50 (4): 617-27 (1978). SEVERAL CASE HISTORIES OF ACTUAL EPA FIELD OPERATIONS IN RESPONSE TO TOXIC CHEM SPILLS ARE DISCUSSED. SOME OF THESE INCL SPILLS OF DINITROBUTYLPHENOL (DINOSEB).BOVEY RWCH09: 301-56 (1980). CURRENT RESEARCH ON THE FATE & PERSISTENCE OF DINOSEB IN THE ENVIRONMENT IS REVIEWED.USEPADrinking Water Criteria Document: Dinoseb (1990) NTIS/PB90-215385.Health Advisories for 50 Pesticides (1988) NTIS/PB88-113543. These documents summarize the health effects of 50 pesticides including: ... dinoseb ... . Topics discussed include: general information and properties, pharmacokinetics, health effects in humans and animals, quantification of toxicological effects, other criteria guidance and standards, analytical methods, and treatment technologies.
RCRA-AnforderungenP020As stipulated in 40 CFR 261.33, when dinoseb, as a commercial chemical product or manufacturing chemical intermediate or an off-specification commercial chemical product or a manufacturing chemical intermediate, becomes a waste, it must be managed according to federal and/or state hazardous waste regulations. Also defined as a hazardous waste is any container or inner liner used to hold this waste or any residue, contaminated soil, water, or other debris resulting from the cleanup of a spill, into water or on dry land, of this waste. Generators of small quantities of this waste may qualify for partial exclusion from hazardous waste regulations (40 CFR 261.5(e)).
FIFRA-AnforderungenTolerances are established for residues of the herbicide, insecticide, and fungicide dinoseb (2-sec-butyl-4,6-dinitrophenol) from application of its phenol or its readily hydrolyzable salts (alkanolamine salts, ammonium salt, or sodium salt) in or on raw agricultural commodities.Tolerances are established for residues of the herbicide, insecticide, and fungicide dinoseb (2-sec-butyl-4,6-dinitrophenol) from application of its phenol or its readily hydrolyzable salts (ammonium salt or sodium salt) in or on raw agricultural commodities.The EPA Administrator has ... ordered the suspension of all registered products containing dinoseb or any of its salts. In addition this notice announces that the Agency intends to deny all pending applications for federal registration of pesticides containing dinoseb.Pesticide chemicals that cause related pharmacological effects will be regarded ... as having an additive deleterious action ... Where residues from two or more chemicals in the same class are present in or on a raw agricultural commodity the tolerance for the total of such residues shall be the same as that for the chemical having the lowest numerical tolerance in this class, unless a higher tolerance level is specifically provided tor the combined residues by a regulation ... Dinoseb (2-sec-butyl-4,6-dinitrophenol) and its alkanolamine, ammonium, and sodium salts are members of the class of dinitrophenols.For more FIFRA Requirements (Complete) data for DINOSEB (6 total), please visit the HSDB record page.
Reactivity AlertsExplosive
BrandbekämpfungThis is a dinitrophenol herbicide. (Non-Specific -- Dinitrophenol, Flammable Solid) Wear self-contained breathing apparatus and full protective clothing. If fire becomes uncontrollable, evacuate for a radius of 5000 feet.Use water spray, foam, powder, carbon dioxide. Combat fire from a sheltered position.
Erste-Hilfe-MaßnahmenFresh air, rest. Artificial respiration may be needed. Refer for medical attention.Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer immediately for medical attention.First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.Rinse mouth. Rest. Give a slurry of activated charcoal in water to drink. Refer immediately for medical attention.
Erste HilfeWarning: Effects may be delayed from several hours to 2 days. Caution is advised. Toxicity of dinoseb is enhanced by high ambient temperature and physical activity.
Sichere LagerungProvision to contain effluent from fire extinguishing. Separated from bases and food and feedstuffs. Cool. Keep in a well-ventilated room. Well closed. Store in an area without drain or sewer access.
LagerbedingungenMATERIALS WHICH ARE TOXIC AS STORED OR WHICH CAN DECOMPOSE INTO TOXIC COMPONENTS ... SHOULD BE STORED IN A COOL WELL VENTILATED PLACE, OUT OF THE DIRECT RAYS OF THE SUN, AWAY FROM AREAS OF HIGH FIRE HAZARD, AND SHOULD BE PERIODICALLY INSPECTED. INCOMPATIBLE MATERIALS SHOULD BE ISOLATED ... .
ReinigungsverfahrenSpillages of pesticides at any stage of their storage or handling should be treated with great care. Liquid formulations may be reduced to solid phase by evaporation. Dry sweeping of solids is always hazardous: these should be removed by vacuum cleaning, or by dissolving them in water, or other solvent in the factory environment.
Freisetung ohne BrandThis is a dinitrophenol herbicide. (Non-Specific -- Dinitrophenol, Flammable Solid) Do not handle broken packages without protective equipment. Wash away any material which may have contacted the body with copious amounts of water. Keep sparks, flames, and other sources of ignition away. Keep material out of water sources and sewers. Keep spilled material wet. Do not attempt to sweep up dry material. (EPA, 1998)
EntsorgungsverfahrenGenerators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number P020, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.Dinoseb is a good candidate for liquid injection incineration, with a temp range of 650 to 1,600 °C and a residence time of 0.1 to 2.0 seconds. Also, a good candidate for rotary kiln incineration, with a temp range of 820 to 1,600 °C with a residence time of seconds. Also, a good candidate for fluidized bed incineration, with a temp range of 450 to 980 °C and a residence time of seconds.Group I Containers: Combustible containers from organic or metallo-organic pesticides (except organic mercury, lead, cadmium, or arsenic compounds) should be disposed of in pesticide incinerators or in specified landfill sites. /Organic or metallo-organic pesticides/Group II Containers: Non-combustible containers from organic or metallo-organic pesticides (except organic mercury, lead, cadmium, or arsenic compounds) must first be triple-rinsed. Containers that are in good condition may be returned to the manufacturer or formulator of the pesticide product, or to a drum reconditioner for reuse with the same type of pesticide product, if such reuse is legal under Department of Transportation regulations (eg 49 CFR 173.28). Containers that are not to be reused should be punctured ... and transported to a scrap metal facility for recycling, disposal or burial in a designated landfill. /Organic or metallo-organic pesticides/Incineration is suggested at 1000 °C (2.0 sec minimum) with adequate scrubbing equipment for the removal of NO(x). Recommendable method: Incineration. Not recommendable method: Hydrolysis. Peer-review: Alkaline and acid hydrolysis not recommendable due to toxicity of the reaction products. (Peer-review conclusions of an IRPTC expert consultation (May 1985))
Verschüttetes entsorgenPersonal protection: filter respirator for organic gases and particulates adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.
Preventive MeasuresSmoking, eating, and drinking before washing should be absolutely prohibited when any pesticide ... is being handled or used. /Pesticides/SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.
Isolation and EvacuationExcerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:
Eye PreventionWear face shield or eye protection in combination with breathing protection.
ZielorganeDevelopmental
ÖkotoxizitätswerteLC50 YEARLING COHO SALMON 100 UG/L/96 HR /CONDITIONS OF BIOASSAY NOT SPECIFIED/LC50 CATFISH 118 PPB/96 HR /CONDITIONS OF BIOASSAY NOT SPECIFIED/LC50 Salmo clarki (Cutthroat trout) 67 ug/l/96 hr @ 10 °C (95% confidence limit 56-81 ug/l), wt 0.3 g /Technical material, 95.8%/ /Static bioassay/LC50 Salvelinus namaycush (Lake trout) 44 ug/l 96 hr @ 10 °C (95% confidence limit 38-51 ug/l), wt 0.3 g /Technical material, 95.8%/ /Static bioassay/For more Ecotoxicity Values (Complete) data for DINOSEB (14 total), please visit the HSDB record page.
UmweltverhaltenTERRESTRIAL FATE: WATER-SOLUBLE SALTS OF DINOSEB ... LEACH READILY IN SOIL. HOWEVER, OIL-SOLUBLE OR WATER-MISCIBLE FORMULATIONS OF DINOSEB MOVED MUCH LESS THAN WATER-SOLUBLE FORMULATIONS.TERRESTRIAL FATE: Dinoseb is expected to biodegrade in slowly soil. It should bind weakly to soil. Therefore, leaching in soil is possible and dinoseb has been detected in groundwater. However, it may bind more strongly to clay soils, specialy at acidic pH. Photolytic degrdration of dinoseb from soil surface may be important. Volatilization is not expected to be significant. In the absence of volatilization, the half-life of dinoseb in the vadose zone sandy loam soil was estimated to be about 100 days(1).AQUATIC FATE: Dinoseb may photodegrade in surface water with a half-life of 14-16 days(1). Hydrolysis in water may not be important(1). Volatilization and adsorption to sediments are not expected to be significant. It is unlikely to undergo significant biodegradation in most natural waters(SRC).ATMOSPHERIC FATE: Based on its vapor pressure of 8.5X10-2 mm Hg at 20 °C(1), dinoseb may exist entirely in the vapor phase in the atmosphere(2). The half-life for the reaction of vapor phase dinoseb with photochemically generated hydroxyl radicals in the atmosphere was estimated to be 4.1 days(3). Due to its water solubility of 52 mg/L at 25 °C(4), some of the atmospheric dinoseb may be removed by wet deposition.RESULTANT AVERAGE PERSISTENCE OF PHYTOTOXICITY @ RECOMMENDED RATES: 2 TO 4 WK UNDER AVERAGE CONDITIONS OF USE.
Unerwünschte WirkungenOccupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.
ExpositionspfadeThe substance can be absorbed into the body by inhalation, through the skin and by ingestion.
Signs and SymptomsSweating. Headache. Laboured breathing. Nausea. Vomiting. Fever. Convulsions. Unconsciousness. CyanosisEASILY ABSORBED! Redness. Further see Inhalation.Redness. Pain.Abdominal pain. Further see Inhalation.
Acute Toxicity LinkChemical: DINOSEB
Effluent ConcentrationsDinoseb was detected at a max concn of 44 ug/L in the agricultural drainage water from potatoe fields in Northwestern New Brunswick, Canada(1).
ICSC Environmental DataThe substance is very toxic to aquatic organisms. This substance may be hazardous to the environment. Special attention should be given to bees, birds and mammals. This substance does enter the environment under normal use. Great care, however, should be taken to avoid any additional release, for example through inappropriate disposal.
EPA IRIS InformationDinosebDevelopmental1 x 10 ^-3 mg/kg-day
Soil Adsorption/MobilityThe measured soil-sorption coefficient (Koc) of dinoseb is 124(1). A Koc of this magnitude suggests that dinoseb will be highly mobile in soil and may leach to groundwater. A much higher Koc value of 6607 wa obtained at a buffered pH of 3(2). It appears that soil sorption may be pH dependent and at low pH adsorption may be stronger. It has been shown, however, that p-nitrophenol adsorbs strongly to clays through an interaction between the nitro group and the water molecules or metallic cations in the clay(3). Dinoseb may similarly bind to clays at low pH. Experiments with soil thin layer chromatography showed that dinoseb was intermediate to very mobile in silt loam sand loam and silty loam soils(4).
Human Toxicity ExcerptsIn a poisoned person, the result is an almost immediate incr in oxygen consumption, body temp, breathing rate, and heart rate. Because circulation and resp do not accelerate in proportion to the metabolic demand, anoxia and acidosis develop. ... It is a milder corrosive to skin and mucous membrane than phenol, but concentrated soln have produced corrosion of the oropharyngeal, esophageal and gastric mucous membranesDinoseb exerts direct actions on the cerebrum and lower brain centers consisting of stimulation followed by depressionIt may produce a necrotizing tubular injury of the kidneys. If the acute phase of poisoning is survived, the patient usually tolerates successfully the later complications, which may include renal insufficiency and a toxic hepatitis. The fulminating type of poisoning is characterized by sudden onset, severe symptoms, and prompt death (within 24 hours). Death is due to resp or circulatory collapse, especially the former. Many factors undoubtedly contribute to this collapse, notably hyperpyrexia, ... dehydration, muscle rigor (due to heat and/or lactic acid), and occasionally pulmonary edema. ... In subacute poisoning due to repeated daily exposures, some individuals complain of lassitude, headache, and malaise, while others experience a disarming sense of well-being, energy, and drive. /Dinitrophenol/YELLOW STAINING OF SKIN & HAIR SIGNIFY CONTACT WITH NITROPHENOLIC CHEMICAL. STAINING OF SCLERAE & URINE INDICATE ABSORPTION OF POTENTIALLY TOXIC AMT. PROFUSE SWEATING, HEADACHE, THIRST, MALAISE, & LASSITUDE ARE COMMON EARLY SYMPTOMS OF POISONING. WARM, FLUSHED SKIN, TACHYCARDIA, & FEVER CHARACTERIZE A SERIOUS DEGREE OF POISONING. APPREHENSION, RESTLESSNESS, ANXIETY, MANIC BEHAVIOR, OR UNCONSCIOUSNESS REFLECT SEVERE CEREBRAL INJURY. ... CYANOSIS, TACHYPNEA & DYSPNEA OCCUR AS CONSEQUENCE OF EXTREME STIMULATION OF METABOLISM, PYREXIA, & TISSUE ANOXIA. WEIGHT LOSS OCCURS IN PERSONS CHRONICALLY POISONED AT LOW DOSAGES. /NITROPHENOLIC COMPOUNDS/... TOXIC TO LIVER, KIDNEY, & NERVOUS SYSTEM. ... LIVER PARENCHYMA & RENAL TUBULES SHOW DEGENERATIVE CHANGES. ALBUMINURIA, PYURIA, HEMATURIA, & INCR BUN ARE OFTEN PROMINENT SIGNS OF RENAL INJURY. ... DEATH IN NITROPHENOL POISONING IS FOLLOWED PROMPTLY BY INTENSE RIGOR MORTIS. /NITROPHENOLIC COMPOUNDS/MOST SEVERE POISONINGS FROM ABSORPTION OF THESE COMPOUNDS HAVE OCCURRED IN WORKERS WHO WERE CONCURRENTLY EXPOSED TO HOT ENVIRONMENTS. /NITROPHENOLIC COMPOUNDS/
CERCLA-MeldepflichtmengenPersons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 1000 lb or 454 kg. The toll free number of the NRC is (800) 424-8802In the Washington D.C. metropolitan area (202) 426-2675. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b).Releases of CERCLA hazardous substances are subject to the release reporting requirement of CERCLA section 103, codified at 40 CFR part 302, in addition to the requirements of 40 CFR part 355. Dinoseb is an extremely hazardous substance (EHS) subject to reporting requirements when stored in amounts in excess of its threshold planning quantity (TPQ) of 100/10,000 lbs.
Landesrichtlinien für Trinkwasser(AZ) ARIZONA 3.5 ug/l
Federal Drinking Water StandardsEPA 7 ug/l
Bundesrichtlinien für TrinkwasserEPA 7 ug/l
UN-Transportnummer2779
Gefahrenklasse6.1
VerpackungsgruppeII