HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Ioddimethylarsin
ME2ASI · iododimethylarsine · dimethyl iodoarsine · iodo(dimethyl)arsane · DIMETHYLARSENIC IODIDE · DiMethylarsinous iodide · Arsinous iodide, dimethyl- · Dimethylarsinous acidiodide
Identifikatoren & physikalische Daten
| CAS No. | 676-75-5 |
|---|---|
| Summenformel | C2H6AsI |
| Durchschnittliche Molmasse | 231,9 g/mol |
| Monoisotopische Masse | 231,87302 g/mol |
| SMILES | C[As](C)I |
| InChIKey | JHQSGZOIIRXESF-UHFFFAOYSA-N |
| PubChem CID | 69608 |
| EC No. | 211-630-2 |
| DTXSID | DTXSID70217921 |
| Lokaler Name | Ioddimethylarsin |
Chemische & physikalische Eigenschaften
| Polarare Oberfläche (TPSA) | 0 |
|---|---|
| H-Brücken-Donoren | 0 |
| H-Brücken-Akzeptoren | 0 |
| Frei drehbare Bindungen | 0 |
| Schwere Atome | 4 |
| Formalladung | 0 |
| Komplexität | 13,5 |
Sicherheit & Vorschriften
| GHS-Einstufung | DangerH302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]P262, P264, P270, P280, P301+P317, P302+P352, P316, P321, P330, P361+P364, P405, and P501 (click each P-code to see the statement)The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory. |
|---|---|
| Regulatorische Informationen | Restricted substance: Iododimethylarsine |
| Alarmwort | Achtung |
| Gefahrenhinweise | Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code H302 |
Anwendungen & Verwendung
Verwenden
Dimethyliodoarsine is a dimethylated metabolite of Arsenic Trioxide that acts as a more potent growth inhibitor and apoptotic inducer in NB4 cells, an APL cell line. Dimethyliodoarsine is an arsenite metabolite in wild type CHO cells and in cells deficient in excision repair cross-complementing 1 and 2. Dimethyliodoarsine is also an inhibitor of Thioredoxin reductase, an enzyme involved in the response of the cell to oxidative stress.