L-Methionin
METHIONINE · MET · H-MET-OH · L-MET · L-Met-OH · l-methionin · Methione · H-L-MET-OH
Identifikatoren & physikalische Daten
| CAS No. | 63-68-3 |
|---|---|
| Summenformel | C5H11NO2S |
| Durchschnittliche Molmasse | 149,21 g/mol |
| Monoisotopische Masse | 149,05104977 g/mol |
| SMILES | CSCC[C@H]([NH3+])C(=O)[O-] |
| InChIKey | FFEARJCKVFRZRR-BYPYZUCNSA-N |
| PubChem CID | 6992087 |
| ChEBI | CHEBI:57844 |
| Lokaler Name | L-Methionin |
Chemische & physikalische Eigenschaften
| XLogP | -1,2 |
|---|---|
| Polarare Oberfläche (TPSA) | 93,1 |
| H-Brücken-Donoren | 1 |
| H-Brücken-Akzeptoren | 3 |
| Frei drehbare Bindungen | 3 |
| Schwere Atome | 9 |
| Formalladung | 0 |
| Komplexität | 91,4 |
| LogP (Verteilungskoeffizient) | -1.87 |
| Löslichkeit | 56.6 mg/mL1 M HCl: 0.5 M at 20 °C, clear, colorlessSoluble |
| Schmelzpunkt | 284 °C284 °C (dec.)(lit.) |
| Physical Description | Solid |
| Dissociation Constants | 2.28 (at 25 °C) |
| Siedepunkt | 393.91°C (estimate) |
| Dichte | 1,34g/cm |
| Brechungsindex | 1.5216 (estimate) |
| Lagerbedingungen | 20-25°C |
| pKa (Säurekonstante) | 2.13(at 25℃) |
| Aggregatzustand | Solid |
| Farbe | White |
| Geruch | Slight characteristic |
| pH | 5-7 (10g/l, H2O, 20℃) |
| Biologische Quelle | synthetic |
| Merck | 14,5975 |
| BRN | 1722294 |
| Stabilität | Stable. Incompatible with strong oxidizing agents. |
| Hauptanwendungen | peptide synthesispharmaceutical (small molecule) |
| InChI | 1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 |
| InChIKey | FFEARJCKVFRZRR-BYPYZUCNSA-N |
| SMILES | CSCC[C@H](N)C(O)=O |
| LogP (Verteilungskoeffizient) | 0.217 (est) |
| CAS Datenbank | 63-68-3(CAS DataBase Reference) |
| NIST chemische Informationen | L-Methionine(63-68-3) |
| EPA chemische Informationen | L-Methionine (63-68-3) |
Sicherheit & Vorschriften
| F | 10-23 |
|---|---|
| Wassergefährdungsklasse (WGK) | 2 |
| TSCA-Inventar-Status | TSCA listed |
| Zollcode | 29304010 |
| RTECS-Nr. | PD0457000 |
| R-Sätze (R) | 33 |
| Toxizität | LD50 oral in rat: 36gm/kg |
| Sicherheitshinweise (S) | 24/25 |
| Lagerklasse | 11 - Combustible Solids |
| Gefahrstoffdaten | 63-68-3(Hazardous Substances Data) |
Anwendungen & Verwendung
Beschreibung
Colorless or white lustrous plates, or a white crystalline powder. It has a slight, characteristic odor. It is soluble in water, in alkali solutions, and in dilute mineral acids. It is slightly soluble in alcohol and practically insoluble in ether.
Verwenden
L-Methionine is used as an essential amino acid for human development and therapeutically acts as an antidote for acetaminophen poisoning. It serves as a chelating agent for heavy metals, as a flavoring agent and nutritional supplement for foods. It acts as a feed additive, vegetable oil enrichment and as a single cell protein. In addition to this, it is used as a hepatoprotectant and also acts as a lipotropic agent and prevents excess fat buildup in the liver.
Herstellung & Synthese
synthetische
The production method of choice for L-methionine is still the enzymatic resolution of racemic N-acetyl-methionine using acylase from Aspergillus oryzae. The production is carried out in a continuously operated fixed-bed or enzyme membrane reactor.