L-Histidine 7-amido-4-methylcoumarin
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Grundinformationen
- CAS
191723-64-5- Standard-SMILES
Cc1cc(=O)oc2cc(NC(=O)[C@@H](N)Cc3cnc[nH]3)ccc12- InChIKey
YSUYDFDITKBMJW-ZDUSSCGKSA-N- Summenformel
- C16H16N4O3
- Durchschnittliche Molmasse
- 312,329 g/mol
- Monoisotopische Masse
- 312,12224037
Namen und Bezeichner
- Bevorzugter Name
- L-Histidine 7-amido-4-methylcoumarin
- IUPAC
- N-(4-Methyl-2-oxo-2H-1-benzopyran-7-yl)-L-histidinamide
- Englischer Name
- H-His-AMC
- Summenformel
- C16H16N4O3
- Molmasse
- 312.32
Namen und Synonyme
1600H-His-AMCH-L-His-AMCL-His-AMC·TFAH-His-AMC.TFAH-HIS-AMC USP/EP/BPH-His-AMC Trifluoroacetate saltL-HISTIDINE 7-AMIDO-4-METHYLCOUMARINL-histidine 7-amindo-4-methylcoumarinL-Histidine 7-amido-4-Methylcoumarine
Datenbank-Bezeichner
- CAS
191723-64-5- PubChem CID
- 7015856
- DTXSID
DTXSID20426783
Eigenschaften
Physikochemische Eigenschaften
- Siedepunkt
- 696 · 696.0±55.0 °C(Predicted)
- Dichte
- 1.413 · 1.413±0.06 g/cm3(Predicted)
- storage temp.
- -15 °C · -15°C
- pka
- 12.69 · 12.69±0.20(Predicted)
Chemie und Industrie
Anwendungen
VerwendenL-Histidine 7-amido-4-methylcoumarin is an enzyme substrate. Substrates of glycosidases, phosphatases and esterases are commonly employed in microbiology, food/water, environmental and ELISA testing. Assays of peptidases are more important in clinical enzyme assays and AMC is the fluorophore employed in most of these substrates. AMC is extremely versatile since the carboxy-terminus of any amino acid or peptide can be linked to it. Most enzymes are tolerant towards the AMC structure. Typically, kinetics of enzyme reactions remain undisturbed and few inhibitory effects are observed. Due to the low basicity of the amino group, AMC is not subject to acid base equilibrium at physiological pH. Therefore, assays using AMC substrates are rather tolerant of pH.
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