| GHS-Einstufung | DangerH314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]P203, P260, P261, P264, P264+P265, P272, P273, P280, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P318, P321, P333+P317, P362+P364, P363, P391, P405, and P501 (click each P-code to see the statement)WarningH315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]P261, P264, P264+P265, P271, P273, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement) |
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| Regulatorische Informationen | Chemical: [1,1'-Biphenyl]-2-olHazard Traits - CarcinogenicityHematotoxicityOther Toxicological Hazard TraitsCommission Regulation (EC) No 2229/20042009/160/EC, 2010/81/EU, Reg. (EU) 2021/1449, Reg. (EU) 2022/1480, Reg. (EU) 2023/2592, Reg. (EU) No 540/2011Status: Active Update: 09-03-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/2168Orthophenyl phenol: Does not have an individual approval but may be used under an appropriate group standard |
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| Weitere Sicherheitsinformationen | Evaluation - 2-phenylphenol and salts |
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| DOT-Kennzeichnung | Class 9 |
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| Brandgefahren | This chemical is combustible. (NTP, 1992)Combustible. Gives off irritating or toxic fumes (or gases) in a fire. Finely dispersed particles form explosive mixtures in air. |
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| Brandpotenzial | This chemical is a combustible solid.Slight, when exposed to heat or flamecan react with oxidizing materials. |
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| Gesundheitsgefahren | SYMPTOMS: Symptoms of exposure to this compound include eye irritation with possible corneal injury (necrosis)paleness, cyanosis, weakness, sweating, headache, diarrhea, nausea, vomiting, diarrhea, dizziness, fainting, dark urine, central nervous system depression, and deoxyribonuclease inhibition. Chronic exposure may include irritation and lesions of the respiratory system. |
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| Gefahrenübersicht | A skin, eye, and respiratory tract irritantMay cause injury to heart, gastrointestinal tract, kidneys, liver, and lungs[ICSC] May cause immunosuppression[HSDB] May cause corneal damage[CAMEO] An irritant[MSDSonline] See Sodium o-phenylphenol. |
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| FDA-Anforderungen | ortho-Phenylphenol is an indirect food additive for use only as a component of adhesives. Limitation: For use as a preservative only. |
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| Reaktive Gruppe | Phenols and Cresols |
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| EG-Einstufung | Symbol: Xi, NR: 36/37/38-50S: (2)-22-61 |
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| UN-Einstufung | UN Hazard Class: 9UN Pack Group: III |
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| Special Reports | USEPA/Office of Pesticide ProgramsReregistration Eligibility Decision Document - 2-Phenylphenol and Salts (Orthophenylphenol or OPP). EPA 739-R-06-004 (July 2006). The RED summarizes the risk assessment conclusions and outlines any risk reduction measures necessary for the pesticide to continue to be registered in the U.S.[Available from, as of October 7, 2009: http://www.epa.gov/pesticides/reregistration/status.htm]IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man. Geneva: World Health Organization, International Agency for Research on Cancer, Vol 73 Some Chemicals that Cause Tumours of the Kidney or Urinary Bladder in Rodents and Some Other Substances 674 pp (1999) is available for downloading in pdf form from the IARC Monographs website.[Available from, as of April 8, 2010: http://monographs.iarc.fr/ENG/Monographs/PDFs/index.php]European Commission, ESISIUCLID Dataset, Biphenyl-2-ol (90-43-7) 153 pp. (2000 CD-ROM edition) contains information on use, toxicology, and environmental effects of this chemical as supplied to the European Union by industry.DHHS/NTPToxicology & Carcinogenesis Studies of ortho-Phenylphenol Alone and With 7,12-Dimethylbenz(a)anthracene in Swiss CD-1 Mice (Dermal Studies) Technical Report Series No. 301 (1986) NIH Publication No. 86-2557 |
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| Brandbekämpfung | Fires involving this chemical can be controlled with a dry chemical, carbon dioxide, foam or Halon extinguisher. (NTP, 1992)Use water spray, powder, alcohol-resistant foam, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water. |
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| Erste-Hilfe-Maßnahmen | Fresh air, rest. Seek medical attention if you feel unwell.Remove contaminated clothes. Rinse and then wash skin with water and soap. Seek medical attention if you feel unwell.First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.Rinse mouth. Give one or two glasses of water to drink. Seek medical attention if you feel unwell. |
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| Erste Hilfe | EYES: Check for contact lenses and remove them at once if present. You should then immediately flush eyes with water from any source for 15 minutes. Do not use oil or ointment in eyes. Arrange immediate transportation to a medical facility. |
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| Sichere Lagerung | Separated from strong oxidants, strong bases and food and feedstuffs. Store only in original container. Provision to contain effluent from fire extinguishing. Store in an area without drain or sewer access. |
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| Firefighting Hazards | Unusual Fire and Explosion Hazards: Violent steam generation or eruption may occur upon application of direct water stream to hot liquids. Do not permit dust to accumulate. When suspended in air dust can pose an explosion hazard. Minimize ignition sources. If dust layers are exposed to elevated temperatures, spontaneous combustion may occur. Dense smoke is produced when product burns. / DOWICIDE* 1 ANTIMICROBIAL/ |
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| Expositionsschutz und Persönliche Schutzausrüstung | 5.0 [mg/m3], inhalable fraction (can also occur as vapor and aerosol)[German Research Foundation (DFG)] |
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| Brandbekämpfungsverfahren | Special Protective Equipment for Firefighters: Wear positive-pressure self-contained breathing apparatus (SCBA) and protective fire fighting clothing (includes fire fighting helmet, coat, trousers, boots, and gloves). If protective equipment is not available or not used, fight fire from a protected location or safe distance. / DOWICIDE* 1 ANTIMICROBIAL/Fire Fighting Procedures: Keep people away. Isolate fire and deny unnecessary entry. Cool surroundings with water to localize fire zone. Do not use direct water stream. May spread fire. Burning liquids may be moved by flushing with water to protect personnel and minimize property damage. Water fog, applied gently may be used as a blanket for fire extinguishment. Contain fire water run-off if possible. / DOWICIDE* 1 ANTIMICROBIAL/Extinguishing Media: Water fog or fine spray. Dry chemical fire extinguishers. Carbon dioxide fire extinguishers. Foam. Do not use direct water stream. May spread fire. Alcohol resistant foams (ATC type) are preferred. General purpose synthetic foams (including AFFF) or protein foams may function, but will be less effective. Water fog, applied gently may be used as a blanket for fire extinguishment. / DOWICIDE* 1 ANTIMICROBIAL/Use dry chemical, carbon dioxide, water spray, or alcohol foam extinguishers ... If material or contaminated runoff enters waterways, notify downstream users of potentially contaminated waters. Notify local health and fire officials and pollution control agencies. From a secure, explosion-proof location, use water spray to cool exposed containers. If cooling streams are ineffective (venting sound increases in volume and pitch, tank discolors or shows any signs of deforming), withdraw immediately to a secure position. |
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| Lagerbedingungen | Store in tightly closed containers in a cool, well-ventilated area away from water. Sources of ignition, such as smoking and open flames, are prohibited where o-phenylphenol is used, handled, or stored in a manner that could create a potential fire or explosion hazard.Safe Storage of Pesticides. Always store pesticides in their original containers, complete with labels that list ingredients, directions for use, and first aid steps in case of accidental poisoning. Never store pesticides in cabinets with or near food, animal feed, or medical supplies. Do not store pesticides in places where flooding is possible or in places where they might spill or leak into wells, drains, ground water, or surface water. |
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| Reinigungsverfahren | SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.Evacuate persons not wearing protective equipment from area of spill or leak until clean-up is complete. Remove all ignition sources. Collect powdered material in the most convenient and safe manner and deposit in sealed containers. Ventilate area after clean-up is complete. It may be necessary to contain and dispose of this chemical as a hazardous waste. If material or contaminated runoff enters waterways, notify downstream users of potentially contaminated waterse.If a spill occurs, clean it up promptly. Don't wash it away. Instead, sprinkle the spill with sawdust, vermiculite, or kitty litter. Sweep it into a plastic garbage bag, and dispose of it as directed on the pesticide product label.After Applying a Pesticide, Indoors or Outdoors. To remove pesticide residues, use a bucket to rinse tools or equipment three times, including any containers or utensils that you used when mixing the pesticide. Then pour the rinsewater into the pesticide sprayer and reuse the solution by applying it according to the pesticide product label directions. After applying any pesticide wash your hands and any other parts of your body that may have come in contact with the pesticide..To prevent tracking pesticides inside, remove or rinse your boots or shoes before entering your home. Wash any clothes that have been exposed to a lot of pesticide separately from your regular wash. |
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| Freisetung ohne Brand | SMALL SPILLS AND LEAKAGE: Should a spill occur while you are handling this chemical, you should dampen the solid spill material with alcohol, then transfer the dampened material to a suitable container. Use absorbent paper dampened with alcohol to pick up any remaining material. Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with alcohol followed by washing with a strong soap and water solution. Do not reenter the contaminate area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. |
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| Entsorgungsverfahren | SRP: Criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.Safe Disposal of Pesticides. The best way to dispose of small amounts of excess pesticides is to use them - apply them - according to the directions on the label. If you cannot use them, ask your neighbors whether they have a similar pest control problem and can use them. If all of the remaining pesticide cannot be properly used, check with your local solid waste management authority, environmental agency, or health department to find out whether your community has a household hazardous waste collection program or a similar program for getting rid of unwanted, leftover pesticides. These authorities can also inform you of any local requirements for pesticide waste disposal.Safe Disposal of Pesticides. An empty pesticide container can be as hazardous as a full one because of residues left inside. Never reuse such a container. When empty, a pesticide container should be rinsed carefully three times and the rinsewater thoroughly drained back onto the sprayer or the container previously used to mix the pesticide. Use the rinsewater as a pesticide, following label directions. Replace the cap or closure securely. Dispose of the container according to label instructions. Do not puncture or burn a pressurized container like an aerosol - it could explode. Do cut or puncture other empty pesticide containers made of metal or plastic to prevent someone from reusing them. Wrap the empty container and put it in the trash after you have rinsed it. |
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| Verschüttetes entsorgen | Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations. |
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| Körperbelastung | Adipose specimens collected in the United States in fiscal year 1982 were analyzed for general volatile and semivolatile organic compounds. Of 46 samples collected, o-phenylphenol was detected in 22 samples (5 samples from people between the ages of 0-14 yrs, 6 samples from people between the ages of 15-44 and 11 samples from people aged 45 or greater)(1). In an analysis of serum from 10 infants exposed to germicidal solutions containing o-phenylphenol, o-phenylphenol was found in the serum of 7 infants at levels of 500-1900 ng/ml(2). In a study comparing semen samples from Danish farmers consuming organically grown commodities as opposed to traditional farmers, the acceptable daily intake of o-phenylphenol among organic farmers was 0.02 mg/kg/day, 1.1% above the acceptable daily intake(3).o-Phenylphenol is rapidly and almost completely excreted in urine as water soluble conjugates and can be quantified using several chromatographic methods. In an occupational study 11 volunteers were treated with 10 consecutive 3 mL applications of undiluted hand disinfectant containing 2 percent o-phenylphenol. The formula was rubbed on the hands for 1 minute, rinsed under running water for 30 seconds, and dried with a paper towel. The total 24 hour urine samples were collected over a 4-day period post treatment and were analyzed by steam distillation followed by gas chromatography. The total o-phenylphenol excreted by the subjects ranged from 2.95 to 7.22 mg, with an average of 4.45 mg on the first day, 1.08 mg on the second day, and only traces on the third and fourth days. 600 mg of o-phenylphenol was applied to each subject, therefore only about 1 percent was absorbed dermally and the remaining washed off(1).The serum of 10 infants with hyperbilirubinaemia who had been exposed to a gemicidal phenolic solution containing 9.8 percent o-phenylphenol was analyzed for the presence of three gemicidal phenols. o-Phenylphenol was detected in the serum of 7 infants with concentrations ranging from 500-1900 ng/L(1).To investigate pesticides as exposure biomarkers during pregnancy, 100 amniotic fluid samples, slated for disposal, were collected at approximately 18 weeks gestation. o-Phenylphenol was detected in 30 percent of the samples with a geometric mean of 0.13 ug/L(1).The mean concentration of o-phenylphenol in personal air samples in Jacksonville, Florida in summer (1986), spring (1987) and winter (1988) was 79.7, 55.6 and 39.7 ng/cu m, respectively(1). o-Phenylphenol was also detected in personal air samples in Springfield, Massachusetts in spring (1987) and winter (1987) at 16.2 and 11.3 ng/cu m, respectively(1). |
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| Wechselwirkungen | F344/DuCrj rats were fed 10,000 or 20,000 mg sodium o-phenylphenol/kg diet, mixed with 2000 mg/kg thiabendazole in diet. The mean body weight of both sexes of both dose groups showed a statistically significant reduction throughout the study. The survival rates were not affected. At a dose level of 1.0% OPP-Na 1/15 males developed a papilloma and 11/15 carcinomas of the urinary bladder, while females were not affected. At a dose level of 2.0% OPP-Na 4/15 males developed papillomas and 10/15 carcinomas of the urinary bladder. 6/15 females showed papillomas and also 6/15 carcinomas of the urinary bladder. Transitional cell hyperplasia of the renal pelvis appeared in 2/15 males and 3/15 females at the 2.0% dose level. Thiabendazole apparently enhanced the carcinogenic effects of OPP-Na in the rat urinary bladder. /Sodium o-phenylphenol/ |
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| Ökotoxizitätswerte | LD50Species: Anas platyrhynchos (Mallard duck) oral >2250 mg a.i./kg /99.2%/ /from table/LC50Species: Anas platyrhynchos (Mallard duck) dietary >5620 ppm (subacute) /99.2%/ /from table/Species: Colinus virginianus (Bobwhite quail) dietary >5620 (subacute) /99.2%/ /from table/EC50Species: Daphnia magna (Water flea, 6-24 hr old)Concentration: 2.1 mg/L for 24 hrEffect: immobilization /Conditions of bioassay not specified in source examined/For more Ecotoxicity Values (Complete) data for o-Phenylphenol (26 total), please visit the HSDB record page. |
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| Umweltverhalten | TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 6,700(SRC), determined from a log Kow of 3.09(2) and a regression-derived equation(3), indicates that o-phenylphenol is expected to be immobile in soil(SRC). Volatilization of o-phenylphenol from moist soil surfaces may be an important fate process(SRC) given an estimated Henry's Law constant of 1.05X10-6 atm-cu m/mole(SRC), derived from its vapor pressure, 2.0X10-3 mm Hg(4), and water solubility, 700 mg/L(5). o-Phenylphenol is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(4). Utilizing the Japanese MITI test, o-phenylphenol reached 47-86% of its theoretical BOD in 2 weeks(6), indicating that biodegradation may be an important environmental fate process in soil(SRC).AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 6,700(SRC), determined from a log Kow of 3.09(2) and a regression-derived equation(3), indicates that o-phenylphenol is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces may occur(4) based upon an estimated Henry's Law constant of 1.05X10-6 atm-cu m/mole(5), derived from its vapor pressure, 2.0X10-3 mm Hg(6), and water solubility, 700 mg/L(7). Using this Henry's Law constant and an estimation method(4), volatilization half-lives for a model river and model lake are 46 days and 366 days, respectively(SRC). The volatilization half-life from a model pond is about 490 days when adsorption is considered(8). According to a classification scheme(9), an estimated BCF of 51(SRC), from its log Kow(2) and a regression-derived equation(10), suggests the potential for bioconcentration in aquatic organisms is moderate(SRC). Biodegradation in water is expected to occur based on a 50% reduction of carbon-14 labeled o-phenylphenol observed in approximately 1 week in river water(11).ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), o-phenylphenol, which has a vapor pressure of 2.0X10-3 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase o-phenylphenol is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC)the half-life for this reaction in air is estimated to be 1.4 hours(SRC), calculated from its rate constant of 2.7X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Reaction to nitrate radical may be important based on o-phenylphenol structural similarity to phenol. Phenol has a half-life of 12 minutes in night-time air based on its reaction with nitrate radicalthe rate constant for this reaction is 3.8X10-12 cu cm/molecule sec(4). By analogy to phenol, o-phenylphenol may degrade very rapidly in night-time air(4). o-Phenylphenol oxidizes in contact with air to form phenylbenzoquinone(5). |
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| Lebensmitteluntersuchungswerte | In a compilation of various data from US Food and Drug Administration studies for fiscal years 1970-1976, o-phenylphenol was positively detected in 101 of 448 large domestic fruit samples at an avg concn of 0.293 ppm(1)it was infrequently detected in fish and shellfish (1 positive sample), in leaf and stem vegetables (10 positive samples), and in vine and ear vegetables (5 positive samples)(1). In an analysis of imported fruits and bananas in Kyoto, Japan, o-phenylphenol residues of 0.1-3.2 ppm were found in all citrus fruits, but no residues were found in bananas(2). o-Phenylphenol concns of 2.3 ppm were found in whole lemons used for making marmalade(3).Analysis of 324 food composites collected from 27 US cities between Oct 1980 and Mar 1982 (as part of the US FDA Total Diet Studies) detected o-phenylphenol in 2 cereal and grain products at an avg concn of 0.007 ppm(1). Analysis of 240 food composites collected from 20 US cities between Oct 1979 and Sept 1980 (as part of the US FDA Total Diet Studies) detected o-phenylphenol in 1 fruit product at a concn of 0.005 ppm(2). Analysis of 2250 food composites collected from US cities between Jun 1969 and July 1976 (as part of the US FDA Total Diet Studies for fiscal years 1970-1976) detected o-phenylphenol in 27 composites (primarily fruits) at levels ranging from a trace (0.001 ppm) to 0.40 ppm(3).The concentration of o-phenylphenol found in foods as a preservative range from 10-12 ppm(1). Fourteen kinds of fruits, 22 kinds of vegetables, and 7 other food items were selected to represent the average Belgian diet from April 1991-March 1993 and analyzed for pesticide content(2). o-Phenylphenol was detected in 27.3% of orange and lemon samples with a mean concentration of 0.153 ppm for oranges and 0.133 ppm for lemons(2). From a variety of Spanish oranges, 86 percent contained levels of o-phenylphenol <10 mg/kg(3). The pesticide content of 27,065 food samples from CA, FL, IN, MA, MI, NC, NY, OR, VA and WI were analyzed for fiscal years 1988-89(3). o-Phenylphenol was not detected in fiscal year 1988 but was detected in fiscal year 1989 in 0.053% of the samples with 2 samples having significantly high levels (concn exceeded state or federal tolerance level)(4). In 1990, 15,919 food samples acquired from 18 states (AR, CA, CT, DE, FL, GA, IN, ME, MI, MN, NY, OR, PA, RI, VA, WA, WI, WY) were analyzed and found to have detectable amounts of o-phenylphenol (concn not specified)(5). A study near the city of Valencia in 2000-2001 analyzed fruits and vegetables by MSPD-LCMS. o-Phenylphenol was detected in 54 percent of the samples. The concentrations found ranged between 0.005-3.34 mg/kg. The average concentrations were 2 ug/kg in chard, 100 ug/kg in onion, 0.8 ug/kg in pepper, 3 ug/kg in banana, 30 ug/kg in lemon, 309 ug/kg in orange, and 165 ug/kg in tangerine(6). In Hyogo Prefecture, Japan a pesticide monitoring study detected o-phenylphenol in oranges (0.27 ug/g), grapefruit (0.12 ug/g), lemons (0.09 ug/g, and 0.66 ug/g)(7). |
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| Unerwünschte Wirkungen | Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation. |
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| Expositionspfade | The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion. |
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| Average Daily Intake | FOOD INTAKE: The 1971-1976 US dietary intake of o-phenylphenol has been calculated to be 0.03 ug/kg body wt/day(1). Based on results from the USFDA's Total Diet Studies, the US dietary intake for fiscal years 1978, 1979, 1980, and 1981/82 has been estimated to be 0.038, 0.046, 0.015, and 0.047 ug/kg body wt/day(2).The average daily intake (ADI) of o-phenylphenol, was calculated to be 20 ug/kg body wt/day. The estimated daily intakes as a percentage of ADI for several fruits and vegetables were 0.0009 in chard, 0.18 in onion, 0.00060 in pepper, 0.006 in banana, 0.013 in lemon, 1.3 in orange, and 0.13 in tangerine for a total of 1.623(1). |
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| Ökotoxizitätsauszüge | /BIRDS and MAMMALS/ In order to establish the toxicity of 2-phenylphenol to avian species, the /Environmental Protection/ Agency required an acute oral toxicity study... The preferred test species is either mallard duck (a waterfowl) or bobwhite quail (an upland game bird). The results ... are provided in the table. The results indicate that 2-phenylphenol is slightly toxic to avian species on an acute oral basis./BIRDS and MAMMALS/ A subacute dietary study... was required /by EPA/ for the wood preservation use of 2-phenylphenol. Results of these studies are provided in the Table. The results indicate that 2-phenylphenol is practically non-toxic to avian species on a subacute dietary basis./AQUATIC SPECIES/ In order to establish the acute toxicity of pesticides to freshwater fish, the /Environmental Protection/ Agency requires freshwater fish toxicity studies ... The preferred test species are rainbow trout (a coldwater fish) and bluegill sunfish (a warmwater fish). Results of submitted studies ... indicate that orthophenylphenol and its sodium salt are moderately toxic to freshwater fish. The guideline requirements for freshwater fish acute studies (850.1075/72-1a and c) have been fulfilled./AQUATIC SPECIES/ Exposure of sea urchin sperm to 0.00001 M, 0.000001 M o-phenylphenol (OPP) for 10 min. did not result in any spermiotoxic effect. Mitotic abnormalities, namely % total mitotic aberrations, mean number of mitoses per embryo, and metaphase/anaphase ratio were induced by OPP. |
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| Signs and Symptoms | Cough. Sore throat.Redness.Redness. Pain.No acute symptoms expected. |
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| Ongoing Test Status | The following link will take the user to the National Toxicology Program (NTP) Test Agent Search Results page, which tabulates all of the "Standard Toxicology & Carcinogenesis Studies", "Developmental Studies", and "Genetic Toxicity Studies" performed with this chemical. Clicking on the "Testing Status" link will take the user to the status (i.e., in review, in progress, in preparation, on test, completed, etc.) and results of all the studies that the NTP has done on this chemical.[Available from: http://ntp-apps.niehs.nih.gov/ntp_tox/index.cfm?fuseaction=ntpsearch.searchresults&searchterm=90-43-7] |
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| Effluent Concentrations | o-Phenylphenol was detected in raw wastewater from a textile finishing plant, probably from use as a dye carrier(1). Wastewater sampled from publicly owned treatment works in Decatur, IL and Bensenville, IL in 1980 contained o-phenylphenol(2). Levels of less than 0.008 ppm were found in sewage samples taken from Phoenix, AZ, but no detections were made in groundwater samples following a rapid infiltration method of sewage disposal(3). o-Phenylphenol was detected in discharges from two of five US leather tanning plants in 1978 and in effluent and sludge from a water treatment plant in Putnam, CT(4). In a four year study carried out in West Germany, o-phenylphenol was found at levels of 0.1-10 ppb in samples from a water filtration plant, at levels of <1-95 ppb in sanatoria wastewater, and at levels 0.1-1.0 ppb in Ruhr River water(4). A survey of sewage waste treatment plants in Germany found that o-phenylphenol was routinely found in influents in concentrations up to 2.6 ug/L (5). Another study at a German sewage treatment plant found that influent contained 1.89 ug/L o-phenylphenol and following treatment effluent had 0.015 ug/L, a 99.2 percent reduction(6). Composite five to seven day samples of chlorinated and unchlorinated primary-treated municipal wastewater were collected at the Iona Island treatment plant in Vancouver, Canada during a 62 day exposure of juvenile chinook salmon from June-August 1983(7). o-Phenylphenol was detected, concn not specified, in the base/neutral fraction of Iona Island wastewater and sludge(7). |
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| FIFRA-Anforderungen | Tolerances are established for combined residues of the fungicide o-phenylphenol and sodium o-phenylphenate, each expressed as o-phenylphenol, from postharvest application of either in or on the following food commodities: [Table#3537]The Agency has completed its assessment of the dietary, occupational, drinking water, and ecological risks associated with the use of pesticide products containing the active ingredient OPP and salts. The Agency has determined that OPP containing products are eligible for reregistration provided that: (i) current data gaps and confirmatory data needs are addressed(ii) the risk mitigation measures outlined in this document are adoptedand (iii) label amendments are made to reflect these measures where necessary. ... Based on its evaluation of OPP and salts, the Agency has determined that OPP products, unless formulated and used as specified in this document, would present risks inconsistent with FIFRA. Accordingly, should a registrant fail to implement any of the risk mitigation measures identified in this document, the Agency may take regulatory action to address the risk concerns from the use of OPP. If all changes outlined in this document are incorporated into the product formulations, then all current risks for OPP and its salts will be substantially mitigated for the purposes of this determination. Once an Endangered Species assessment is completed, further changes to these registrations may be necessary as explained in Section III of this document.As the federal pesticide law FIFRA directs, EPA is conducting a comprehensive review of older pesticides to consider their health and environmental effects and make decisions about their continued use. Under this pesticide reregistration program, EPA examines newer health and safety data for pesticide active ingredients initially registered before November 1, 1984, and determines whether the use of the pesticide does not pose unreasonable risk in accordance to newer saftey standards, such as those described in the Food Quality Protection Act of 1996. Pesticides for which EPA had not issued Registration Standards prior to the effective date of FIFRA '88 were divided into three lists based upon their potential for human exposure and other factors, with List B containing pesticides of greater concern than those on List C, and with List C containing pesticides of greater concern than those on List D. o-Phenylphenol is found on List B. Case No: 2575Pesticide type: fungicide, antimicrobialCase Status: OPP is reviewing data from the pesticide's producers regarding its human health and/or environmental effects, or OPP is determining the pesticide's eligibility for reregistration and developing the RED /Reregistration Eligibility Decision/ document.Active ingredient (AI): o-phenylphenolData Call-in (DCI) Date(s): 8/2/91, 5/12/95, 10/13/95AI Status: The producers of the pesticide have made commitments to conduct the studies and pay the fees required for reregistration, and are meeting those commitments in a timely manner. |
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| Landesrichtlinien für Trinkwasser | (FL) FLORIDA 18 ug/L |
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![Molekülstruktur von [1,1'-Biphenyl]ol](/img/chemical/7017.png)