1,2-Benzoldicarbonitril

Fresh air, rest. Refer for medical attention.

Rinse skin with plenty of water or shower.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Give a slurry of activated charcoal in water to drink. Refer for medical attention .

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. Carefully collect remainder. Then store and dispose of according to local regulations.

Antidotes to cyanide poisoning include hydroxocobalamin and sodium nitrite, which release the cyanide from the cytochrome system, and rhodanase, which is an enzyme occurring naturally in mammals that combines serum cyanide with thiosulfate, producing comparatively harmless thiocyanate. Oxygen therapy can also be administered. (L97)

Exposure to high levels of cyanide for a short time harms the brain and heart and can even cause coma, seizures, apnea, cardiac arrest and death. Chronic inhalation of cyanide causes breathing difficulties, chest pain, vomiting, blood changes, headaches, and enlargement of the thyroid gland. Skin contact with cyanide salts can irritate and produce sores. (L96, L97)

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 82(SRC), determined from a log Kow of 0.99(2) and a regression-derived equation(3), indicates that 1,2-benzenedicarbonitrile is expected to have high mobility in soil(SRC). Volatilization of 1,2-benzenedicarbonitrile from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 5.0X10-7 atm-cu m/mole(SRC), using a fragment constant estimation method(4). 1,2-Benzenedicarbonitrile is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 3.75X10-2 mm Hg(5).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 82(SRC), determined from a log Kow of 0.99(2) and a regression-derived equation(3), indicates that 1,2-benzenedicarbonitrile is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 5.0X10-7 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). According to a classification scheme(5), a range of BCF values of 0.8 to <5.5 for carp(6), suggests the potential for bioconcentration in aquatic organisms is low(SRC).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 1,2-benzenedicarbonitrile, which has a vapor pressure of 3.75X10-2 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere(SRC). Vapor-phase 1,2-benzenedicarbonitrile is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 356 days(SRC), calculated from its rate constant of 4.5X10-14 cu cm/molecule-sec at 25 °C(SRC) determined using a structure estimation method(3).

The substance can be absorbed into the body by inhalation and by ingestion.

Oral (L96) ; inhalation (L96) ; dermal (L96)

Organic nitriles decompose into cyanide ions both in vivo and in vitro. Consequently the primary mechanism of toxicity for organic nitriles is their production of toxic cyanide ions or hydrogen cyanide. Cyanide is an inhibitor of cytochrome c oxidase in the fourth complex of the electron transport chain (found in the membrane of the mitochondria of eukaryotic cells). It complexes with the ferric iron atom in this enzyme. The binding of cyanide to this cytochrome prevents transport of electrons from cytochrome c oxidase to oxygen. As a result, the electron transport chain is disrupted and the cell can no longer aerobically produce ATP for energy. Tissues that mainly depend on aerobic respiration, such as the central nervous system and the heart, are particularly affected. Cyanide is also known produce some of its toxic effects by binding to catalase, glutathione peroxidase, methemoglobin, hydroxocobalamin, phosphatase, tyrosinase, ascorbic acid oxidase, xanthine oxidase, succinic dehydrogenase, and Cu/Zn superoxide dismutase. Cyanide binds to the ferric ion of methemoglobin to form inactive cyanmethemoglobin. (L97)

Dizziness. Headache. Nausea. Vomiting. Convulsions. Unconsciousness.

Dizziness. Headache. Nausea. Vomiting. Convulsions. Unconsciousness.

Cyanide poisoning is identified by rapid, deep breathing and shortness of breath, general weakness, giddiness, headaches, vertigo, confusion, convulsions/seizures and eventually loss of consciousness. (L96, L97)

The Koc of 1,2-benzenedicarbonitrile is estimated as 82(SRC), using a measured log Kow of 0.99(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that 1,2-benzenedicarbonitrile is expected to have high mobility in soil(SRC).

COMPARISON OF 20 WORKERS (AGE 32-62) WITH POSSIBLE EXPOSURE FOR 2-24 YR, FROM WHICH 7 SUFFERED ACUTE POISONING IN 1953-66, WITH CORRESPONDING CONTROL GROUP SHOWED NO SIGNIFICANT DIFFERENCES IN CHROMOSOMES.

MORTALITY RATE OF 221 EXPOSED WORKERS WAS INSIGNIFICANTLY GREATER THAN THAT OF INTERNAL OR EXTERNAL CONTROL GROUPS.

NO EVIDENCE FOR CHRONIC TOXICITY OF PHTHALONITRILE WAS FOUND. EXAM OF EXPOSED WORKERS FOR LEUKOSIS OR CARCINOGENIC EFFECTS, CLINICAL & NEUROLOGICAL EXAM OF 81 EXPOSED WORKERS, EEG STUDIES OF WORKERS GAVE RESULTS WITHIN NORMAL LIMITS.

1,2-Benzenedicarbonitrile's production and use as an intermediate in organic synthesis (esp, pigments and dyes) and as a base material for high temperature lubricants and coatings(1) may result in its release to the environment through various waste streams(SRC).