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4-Morpholinopropansulfonsäure
MOPS · 3-(N-MORPHOLINO)PROPANESULFONIC ACID · 3-MORPHOLINOPROPANESULFONIC ACID · MOPS FREE ACID · 4-propanesulfonyl morpholine · 3-Morpholin-4-ylpropane-1-sulfonic acid · MORPHOLINOPROPANE SULFONIC ACID · 3-Morpholinopropanesulfoinc Acid
Identifikatoren & physikalische Daten
| CAS No. | 1132-61-2 |
|---|---|
| Summenformel | C7H15NO4S |
| Durchschnittliche Molmasse | 209,27 g/mol |
| Monoisotopische Masse | 209,07217913 g/mol |
| SMILES | O=S(=O)(O)CCCN1CCOCC1 |
| InChIKey | DVLFYONBTKHTER-UHFFFAOYSA-N |
| PubChem CID | 70807 |
| ChEMBL | CHEMBL1234443 |
| ChEBI | CHEBI:44115 |
| EC No. | 214-478-5 |
| DTXSID | DTXSID4044371 |
| Lokaler Name | 4-Morpholinopropansulfonsäure |
Chemische & physikalische Eigenschaften
| XLogP | -3,1 |
|---|---|
| Polarare Oberfläche (TPSA) | 75,2 |
| H-Brücken-Donoren | 1 |
| H-Brücken-Akzeptoren | 5 |
| Frei drehbare Bindungen | 4 |
| Schwere Atome | 13 |
| Formalladung | 0 |
| Komplexität | 227 |
| Physical Description | White solid[Merck Index] White odorless powder[Caledon Laboratories MSDS] |
| Collision Cross Section | 142.7 Ų [M+H]+ [CCS Type: DTBuffer gas: N2Ionization: APCI+Dataset: TOXCASTSource Identifier: DTXSID4044371]149.5 Ų [M-H]- [CCS Type: DTIonization: ESI-154.6 Ų [M+Na]+ [CCS Type: DTIonization: ESI+142.4 Ų [M+H]+ [CCS Type: DT |
| Schmelzpunkt | 277-282 °C |
| Dichte | 1.3168 (rough estimate) |
| Dampfdruck | 0Pa at 25℃ |
| Brechungsindex | 1.6370 (estimate) |
| Flammpunkt | 116 °C |
| Lagerbedingungen | room temp |
| Löslichkeit | H2O: 1 M at 20 °C, clear1000 g/L (20 ºC) |
| Aggregatzustand | Powder/Solid |
| Farbe | White |
| pH | 2.5-4.0 (25℃, 1M in H2O) |
| pKa (Säurekonstante) | 7.2(at 25℃) |
| Geruch | Odorless |
| Biologische Quelle | synthetic |
| Merck | 14,6265 |
| BRN | 1106776 |
| Stabilität | Stable. Incompatible with strong bases, strong oxidizing agents. |
| Kosmetik-Inhaltsstoffe Funktionen | BUFFERINGBLEACHING |
| InChI | 1S/C7H15NO4S/c9-13(10,11)7-1-2-8-3-5-12-6-4-8/h1-7H2,(H,9,10,11) |
| InChIKey | DVLFYONBTKHTER-UHFFFAOYSA-N |
| SMILES | OS(=O)(=O)CCCN1CCOCC1 |
| LogP (Verteilungskoeffizient) | -2.94 at 20℃ |
| CAS Datenbank | 1132-61-2(CAS DataBase Reference) |
| EPA chemische Informationen | 4-Morpholinepropanesulfonic acid (1132-61-2) |
| Absorption | ≤0.05 at 260nm≤0.05 at 280nm |
Sicherheit & Vorschriften
| GHS-Einstufung | This chemical does not meet GHS hazard criteria for 45.9% (189 of 412) of reports.WarningH315 (53.4%): Causes skin irritation [Warning Skin corrosion/irritation]H319 (53.4%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]H335 (52.7%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposureRespiratory tract irritation]P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 412 reports by companies from 18 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.Reported as not meeting GHS hazard criteria per 189 of 412 reports by companies.There are 16 notifications provided by 223 of 412 reports by companies with hazard statement code(s).Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. |
|---|---|
| Regulatorische Informationen | Chemical: 4-Morpholinepropanesulfonic acidStatus: Active Update: 06-12-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/21270Status: Active Update: 09-11-2017 https://echa.europa.eu/registration-dossier/-/registered-dossier/21115MOPS: Does not have an individual approval but may be used under an appropriate group standard |
| Gefahrenübersicht | May cause irritation[Caledon Laboratories MSDS] See N-Ethylmorpholine. |
| Hazard Classes and Categories | Skin Irrit. 2 (53.4%)Eye Irrit. 2 (53.4%)STOT SE 3 (52.7%) |
| Wassergefährdungsklasse (WGK) | 1 |
| TSCA-Inventar-Status | TSCA listed |
Anwendungen & Verwendung
Verwenden
Due to its inert nature, 3-morpholinopropanesulfonic acid (MOPS) is widely used as a buffer in many biochemical studies. MOPS has been used as a cell culture additive component in lentiviral particle production, a buffering agent in microbial growth medium and nuclei extraction buffer, a component of Roswell Park Memorial Institute (RPMI) medium for diluting fungal inoculum, and a buffer in capillary-zone electrophoresis to test performance. It is also used for the dilution of proteins from algal samples.