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3-Cyclohexylaminopropan-1-sulfonsäure
CAPS · 3-(CYCLOHEXYLAMINO)-1-PROPANESULFONIC ACID · Seals · N-Cyclohexyl-3-aminopropanesulfonic acid · CAPS3 · Push-on caps · CAPS, ULTROL · CAPS ULTRAPURE
Identifikatoren & physikalische Daten
| CAS No. | 1135-40-6 |
|---|---|
| Summenformel | C9.H19.N.O3.S |
| Durchschnittliche Molmasse | 221,32 g/mol |
| Monoisotopische Masse | 221,10856447 g/mol |
| SMILES | O=S(=O)(O)CCCNC1CCCCC1 |
| InChIKey | PJWWRFATQTVXHA-UHFFFAOYSA-N |
| PubChem CID | 70815 |
| ChEBI | CHEBI:191088 |
| EC No. | 214-492-1 |
| DTXSID | DTXSID3061554 |
| Lokaler Name | 3-Cyclohexylaminopropan-1-sulfonsäure |
Chemische & physikalische Eigenschaften
| XLogP | -1,4 |
|---|---|
| Polarare Oberfläche (TPSA) | 74,8 |
| H-Brücken-Donoren | 2 |
| H-Brücken-Akzeptoren | 4 |
| Frei drehbare Bindungen | 5 |
| Schwere Atome | 14 |
| Formalladung | 0 |
| Komplexität | 239 |
| Stoffklassen | Other Uses -> Biological Buffers |
| Arzneimittel | Pharmaceuticals -> Listed in ZINC15 |
| Physical Description | Colorless solid[Merck Index] White powder[Sigma-Aldrich MSDS] |
| Schmelzpunkt | >300 °C(lit.) |
| Dichte | 1.1809 (rough estimate) |
| Dampfdruck | 0Pa at 25℃ |
| Brechungsindex | 1.5250 (estimate) |
| Flammpunkt | >110℃ |
| Lagerbedingungen | room temp |
| Löslichkeit | H2O: 0.5 M at 20 °C, clear9 g/100 mL (20 ºC) |
| Aggregatzustand | Powder/Solid |
| Farbe | White |
| Geruch | Odorless |
| pH | 3.0-7.0 (20℃, 0.5M in H2O) |
| pKa (Säurekonstante) | 10.4(at 25℃) |
| Merck | 14,1767 |
| BRN | 2835588 |
| Stabilität | Stable. Incompatible with strong oxidizing agents. |
| InChI | 1S/C9H19NO3S/c11-14(12,13)8-4-7-10-9-5-2-1-3-6-9/h9-10H,1-8H2,(H,11,12,13) |
| InChIKey | PJWWRFATQTVXHA-UHFFFAOYSA-N |
| SMILES | OS(=O)(=O)CCCNC1CCCCC1 |
| LogP (Verteilungskoeffizient) | 0.3 at 25℃ |
| CAS Datenbank | 1135-40-6(CAS DataBase Reference) |
| EPA chemische Informationen | 1-Propanesulfonic acid, 3-(cyclohexylamino)- (1135-40-6) |
| Absorption | ≤0.2 at 260 in H2O at 0.5M≤0.2 at 280 in H2O at 0.5M |
Sicherheit & Vorschriften
| GHS-Einstufung | This chemical does not meet GHS hazard criteria for 85.9% (67 of 78) of all reports.WarningH315 (11.5%): Causes skin irritation [Warning Skin corrosion/irritation]P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 78 reports by companies from 9 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| Regulatorische Informationen | Status: Active Update: 20-08-2018 https://echa.europa.eu/registration-dossier/-/registered-dossier/202351-Propanesulfonic acid, 3-(cyclohexylamino)-: Does not have an individual approval but may be used under an appropriate group standard |
| Gefahrenübersicht | May cause irritationToxic by ingestion[Sigma-Aldrich MSDS] |
| Hazard Classes and Categories | Skin Irrit. 2 (11.5%) |
| Protective Action Criteria (PAC) | 12 [mg/m3]130 [mg/m3]790 [mg/m3] |
| F | 34 |
| Wassergefährdungsklasse (WGK) | 3 |
| TSCA-Inventar-Status | TSCA listed |
| Zollcode | 29213099 |
| RTECS-Nr. | TZ6395000 |
| R-Sätze (R) | 36/38-36/37/38-22-20/21/22-40/22 |
| Gefahrensymbole | Xi,Xn |
| Sicherheitshinweise (S) | 26-36/37/39-37/39-24/25-22-23-36 |
| Lagerklasse | 11 - Combustible Solids |
Anwendungen & Verwendung
Beschreibung
3-Cyclohexylaminopropanesulfonic Acid, also known as 3-(Cyclohexylamino)-1-propanesulfonic acid (CHAPS) or N-Cyclohexyl-3-aminopropanesulfonic acid, is a detergent with a high affinity for basic proteins that can be used to extract these proteins from biological samples and solubilize them. CHAPS is a type of ampholyte, which means it has both anionic and cationic groups.